Polycystic Ovary Syndrome: The influence of environmental and genetic factors

Evanthia Diamanti-Kandarakis, Christina Piperi, Georgia Argyrakopoulou, Jiovanna Spina, Lambrini Papanastasiou, Angeliki Bergiele, Dimitrios Panidis

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Polycystic ovary syndrome (PCOS) is a complex and heterogeneous disorder characterized by hyperandrogenemia, hyperinsulinemia, insulin resistance, and chronic anovulation. It is the most common endocrine disorder in women of reproductive age with an enigmatic pathophysiologic and molecular basis. The high prevalence of affected …

Aging and glycoxidant stress

Melpomeni Peppa, Jaime Uribarri, Helen Vlassara

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Aging and related diseases are accompanied by increased Oxidative Stress (OS) and accumulation of Advanced Glycation End products (AGEs). One important component of AGEs accumulation with aging appears to be the sustained exposure to dietary AGE (dAGEs), which contributes to overloading of anti-AGE receptors and depletion of anti-oxidant reserves …