Endocrine evaluation of patients after brain injury: what else is needed to define specific clinical recommendations?

Gemma Sesmilo, Irene Halperin, Manuel Puig-Domingo

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Brain injury (BI), both head trauma (TBI) and subarachnoid hemorrage (SAH), has consistently been recognized as an important cause of pituitary dysfunction.1 Different studies have estimated that 20-50% of patients who have suffered BI will develop some degree of hypopituitarism.1-9 The high incidence of BI ranks it as potentially the most important cause of hypothalamic-pituitary dysfunction…