Volume 5 (2006)

Estradiol and progesterone supplementation during luteal phase improved the receptivity of the endometrium in a patient with a history of diethylstilboestrol exposure in-utero

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Dimitris Loutradis, Konstantinos Stefanidis, Erasmia Kiapekou, Evangelia Zapanti, Chrisoula Panitsa-Faflia, Aristidis Antsaklis

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BACKGROUND: Diethylstilboestrol (DES) exposure in-utero has been shown to have negative effects on pregnancy. DES-exposed women are at increased risk of early spontaneous pregnancy loss, ectopic gestation and infertility. DESIGN: A 34-year old woman with a 6-year history of primary infertility is presented. The patient underwent in vitro fertilization (IVF) treatment without success…

An intrasellar germinoma with normal cerebrospinal fluid ?-HCG concentrations misdiagnosed as hypophysitis

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Nese Ozbey, Altay Sencer, Sinan Tanyolac, Ramazan Kurt, Serra Sencer, Bilge Bilgic, Inan Turantan, Senay Molvalilar

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A patient with an intrasellar germinoma leading to pituitary stalk thickening is reported. The patient, a 24-year old woman, presented with hyperprolactinemia, secondary hypothyroidism, and hypogonadotropic hypogonadism with no evidence of diabetes insipidus. Cerebrospinal fluid (CSF) examination revealed an increased number of lymphocytes and histiocytes…

A novel splicing mutation in exon 4 (456G>A) of the GH1 gene in a patient with congenital isolated growth hormone deficiency

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Olga V. Fofanova, Oleg V. Evgrafov, Alexander V. Polyakov, Valentina A. Peterkova, Ivan I. Dedov

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Isolated Growth Hormone Deficiency (IGHD) due to GH1 gene defects has a variable inheritance pattern: autosomal recessive, autosomal dominant, and X-linked. the autosomal dominantly inherited form, IGHD II, is mainly caused by heterozygous mutations of splicing around the exon 3/IVs3 boundary region of the GH1 gene resulting in exon 3 skipping of transcripts …

Hermaphroditism in Greek and Roman antiquity

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George Androutsos

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Since antiquity hermaphrodites have fascinated the mind and excited the imagination. In this paper, such subjects are discussed as legends about the nativity of Hermaphroditus, son of Hermes and Aphrodite, the social status of these bisexual beings, and their fate in Greek-Roman antiquity…

Diabetic retinopathy: An historical assessment

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George Kalantzis, Michael Angelou, Effie Poulakou-Rebelakou

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Diabetic retinopathy is a microvascular complication of diabetes mellitus and is a significant cause of new-onset blindness. Diabetic macular changes in the form of yellowish spots and full or partial thickness extravasations through the retina were observed for the first time by Eduard Jäger. In 1855, he published “Beiträge zur Pathologie des Auges” where he included his fundus paintings…

Follicular carcinoma of the thyroid with aggressive metastatic behavior in a pregnant woman: Report of a case and review of the literature

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Luciana Parlea, Lisa Fahim, David Munoz, Amir Hanna, Jennifer Anderson, Michael Cusimano, Kalman Kovacs, Geoffrey Gardiner

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Distant metastases as initial presentation of follicular carcinoma of the thyroid is rare, especially in young patients. We report the clinical and pathological features of a 33-year old pregnant patient with follicular carcinoma of the thyroid who presented with widespread bone and lung metastases at the time of diagnosis…

Nobel prize winner Christian de Duve. From insulin to lysosomes

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Jean-Pierre Tricot

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A brief biographical note about the most honoured living scientist in Belgium, the physician, biochemist and Nobel Prize winner Christian de Duve, his research in the field of diabetes mellitus and how his revelation led to the discovery of lysosomes and to the prestigious Nobel Prize of 1974 in Physiology and Medicine is herein presented…

Papillary thyroid carcinoma producing granulocyte-macrophage colony-stimulating factor is associated with neutrophilia and eosinophilia

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Evangeline Vassilatou, Markos Fisfis, George Morphopoulos, Sotiria Savva, Eugenia Voucouti, Katerine Stefanoudaki, Ioanna Tzavara

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Thyroid tumors producing colony-stimulating factors associated with neutrophilia and/or eosinophilia are very rare and almost all of them concern anaplastic thyroid cancer. Only one case of papillary thyroid carcinoma associated with neutrophilia and one case of medullary thyroid carcinoma associated with eosinophilia have been reported.

Oskar Minkowski (1858-1931). An outstanding master of diabetes research

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Victor Jörgens

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Oskar Minkowski, a physician of many talents, was an outstanding clinical scientist, a brilliant experimental investigator and a prolific medical writer. His name is connected with highly important clinical studies and experimental probes, all of which significantly contributed to our understanding of the pathogenesis of diabetes mellitus after removal of the pancreas (experimental pancreatectomy).