Atypical, invasive, recurring Crooke cell adenoma of the pituitary

Fabio Rotondo, Michael Cusimano, Bernd W. Scheithauer, Claire Coire, Eva Horvath, Kalman Kovacs

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We report the case of a 49-year-old woman presenting with Cushing disease and visual disturbance. An atypical, aggressive, invasive pituitary tumor regrew despite several surgeries. Detailed morphologic investigation by histology, immunohistochemistry and electron microscopy documented …

Effect of Temozolomide in a patient with recurring oncocytic gonadotrophic pituitary adenoma

Luis V. Syro, Bernd W. Scheithauer, Leon D. Ortiz, Camilo E. Fadul, Eva Horvath, Fabio Rotondo, Kalman Kovacs

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The patient was a 70-year-old man with a recurrent pituitary tumor. Three surgeries were performed but the tumor recurred. Based on histologic, immunohistochemical and ultrastructural studies, the diagnosis of oncocytic gonadotrophic pituitary adenoma was made. The tumor was a macroadenoma partly immunopositive for LH …