The role of Notch and Hedgehog signaling pathways in pituitary development and pathogenesis of pituitary adenomas

Maria P. Yavropoulou, Anna Maladaki, John G. Yovos

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Pituitary adenomas are usually benign tumors that cause symptoms by compression of surrounding structures or impaired hormone secretion. Treatment, whether surgical or medical depends, on the tumor subtype and degree of compression; however, a significant proportion of patients do not achieve optimal control …