The role of Notch and Hedgehog signaling pathways in pituitary development and pathogenesis of pituitary adenomas

Maria P. Yavropoulou, Anna Maladaki, John G. Yovos

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Pituitary adenomas are usually benign tumors that cause symptoms by compression of surrounding structures or impaired hormone secretion. Treatment, whether surgical or medical depends, on the tumor subtype and degree of compression; however, a significant proportion of patients do not achieve optimal control …

A case of idiopathic granulomatous hypophysitis

Nilufer Ozdemir Kutbay, Mustafa Berker, Figen Soylemezoglu, Hatice Ozisik, Banu Sarer Yurekli

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Dear Sir, Hypophysitis is a rare disease of the pituitary gland whose incidence is 1 case per 9 million people per year. Hypophysitis, which can be categorized as primary (idiopathic) hypophysitis and secondary hypophysitis, may develop through systemic inflammatory disorders such as tuberculosis, Wegener’s granulomatosis and sarcoidosis. Based on histologic features …