Atypical, invasive, recurring Crooke cell adenoma of the pituitary

Fabio Rotondo, Michael Cusimano, Bernd W. Scheithauer, Claire Coire, Eva Horvath, Kalman Kovacs

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We report the case of a 49-year-old woman presenting with Cushing disease and visual disturbance. An atypical, aggressive, invasive pituitary tumor regrew despite several surgeries. Detailed morphologic investigation by histology, immunohistochemistry and electron microscopy documented …