IGF-II – HORMONES (Archive)

The effect of long-term somatostatin analogue treatment on free and total insulin-like growth factor (IGF) -I, -II and IGF binding protein -1, -2 and -3 serum levels in euthyroid patients with active thyroid eye disease

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Gerasimos Krassas, Nikolaos Pontikides, Argyrios Dumas, Jan Frystyk, Jian-WenChen, Allan Flyvbjerg

The aim of this study was to investigate the effect of long-term somatostatin analogue (SM-a) treatment on serum levels of free (F) and total (T) insulin-like growth factor (IGF)-I, -II and IGF binding protein (IGFBP) – 1, -2 and -3 in euthyroid patients with active thyroid ophthalmopathy. For this purpose, we measured the above-mentioned parameters …

Hypoglycaemia secondary to the secretion of pro-insulin like growth factor ii by a metastatic neuroendocrine tumour with sarcomatous differentiation

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Mia Morgan, Alexandra Nanzer, Cecilia Camacho-Hubner, Gregory A. Kaltsas, John P. Monson

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A patient presented with frequent episodes of spontaneous hypoglycaemia due to a disseminated neuroendocrine tumour with sarcomatous differentiation, secreting incompletely processed pro-insulin-like growth factor II (pro-IGF-II). Although the combination of GH and glucocorticoid therapy initially controlled the hypoglycaemia …