Cinzia Carrozza, Rosa Lapolla, Jacopo Gervasoni, Carlo Antonio Rota, Pietro Locantore, Alfredo Pontecorvi, Cecilia Zuppi, Silvia Persichilli
OBJECTIVE: Mitotane is an adrenocytolytic agent used in adrenocortical carcinoma, inducing adrenal insufficiency, requiring replacement treatment. Such therapy is not easy to monitor because of mitotane interference. Salivary cortisol reflects a free fraction of plasma …