The serum triiodothyronine to thyroxine (T3/T4) ratio in various thyroid disorders and after Levothyroxine replacement therapy

A. Mortoglou, H. Candiloros

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In order to examine the significance of differences in the triiodothyronine/thyroxine (T3/T4) ratio in the achievement of euthyroidism and in different thyroidal diseases, we studied 1050 subjects: 233 were euthyroid (Eu), 239 hypothyroid (Hypo) with initial TSH levels >15 mU/L, 273 hypothyroid on substitution therapy with L-thyroxine alone and TSH values of 0.35-3.5 mU/L, (hypoRx), 236 hyperthyroid (hyper) and 69 …

Familial paraganglioma: A novel presentation of a case and response to therapy with radiolabelled MIBG

Justin K. Lawrence, Eamonn R. Maher, Richard Sheaves, Ashley B. Grossman

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Phaeochromocytomas (PC) and paragangliomas are disorders of the sympatho-adrenomedullary system. They are chromaffin-containing neuroendocrine tumors of neural crest origin that contain catecholamine-secreting granules: they arise from either the adrenal medulla (phaeochromocytomas) or from extra-adrenal neural crest derivatives e.g. the sympathetic chain (paragangliomas)…

Primary Adrenal lymphoma presented with adrenal insufficiency

Evanthia Diamanti-Kandarakis, Pantelis Chatzismalis, Frangiskos Economou, Stefanos Lazarides, Athena Androulaki, Grigorios Kouraklis

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We report a 71-year old man who presented with symptoms of adrenal insufficiency and large bilateral adrenal masses. Computed tomography guided FNA biopsy was not diagnostic. However, because of the rapid growth of the masses, the negative workup for primary malignancy and the strong clinical suspicion of a lymphoma, an open biopsy was performed and a B-cell lymphoma was disclosed…

Symptomatic pheochromocytoma with normal urinary catecholamine metabolites

Dimitra Zianni, Marinella Tzanela, Serafim Klimopoulos, N.C. Thalassinos

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A 61-year old female presented with paroxysmal hypertension and a 4.5cm left adrenal mass on CT scan. Repeated measurements of 24-hour urinary fractionated metanephrines, total catecholamines and vanillylmandelic acid (VMA) were within normal range. A further scintigraphic study …