The Sertoli cell as the orchestra conductor of spermatogenesis: spermatogenic cells dance to the tune of testosterone

Fotios Dimitriadis, Chara Tsiampali, Nikolaos Chaliasos, Panagiota Tsounapi, Atsushi Takenaka, Nikolaos Sofikitis

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Spermatogenesis is contingent upon hormones and growth factors acting through endocrine and paracrine pathways either in vivo or in vitro. Sertoli cells (SCs) furnish essential factors for the successful advancement of spermatogenesis and spermiogenesis. Moreover, receptors for follicle stimulating hormone (FSH) and testosterone …