PTH and PTHR1 in osteocytes. New insights into old partners

Maria P. Yavropoulou, Alexandros Michopoulos, John G. Yovos

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Parathyroid hormone receptors are present in bone cells and play a crucial role in the maintenance of skeletal integrity, bone homeostasis and regulation of calcium and phosphate metabolism. Although the function of these receptors has long being recognized in the cells of the osteoblastic lineage regulating directly osteoblast differentiation and function and indirectly osteoclastogenesis …