Assimina Galli-Tsinopoulou, Sanda Nousia-Arvanitakis, Ioannis Tsinopoulos, Christos Bechlivanides, Orit Shevah, Zvi Laron
Laron-type dwarfism is an autosomal recessive disorder caused by deletions or mutations of the growth hormone receptor gene. It is characterized by high circulating levels of growth hormone (GH) and low levels of insulin-like growth factor I (IGF-I). Patients are refractory to both endogenous and exogenous GH, and present severe growth retardation and obesity …