Pegvisomant-primed growth hormone (GH) stimulation test is useful in identifying true GH deficient children

Giorgio Radetti, Heba H. Elsedfy, Randa Khalaf, Cristina Meazza, Sara Pagani, Mohamed El Kholy, Riccardo Albertini, Anna Maria De Stefano, Antonella Navarra, Annalisa De Silvestri, Mauro Bozzola

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OBJECTIVE: Provocative stimulation tests for growth hormone (GH) assessment have poor reproducibility and can often elicit false positive results in normal children. The aim of our study was to confirm the capability of pegvisomant as an enhancer of GH secretion in unmasking false-positive results in short children (height <-2.0 standard deviation score, SDS) undergoing GH testing ...