Adeela Shahid, Khalid P. Lone, Sadia Saeed, Muhammad Arslan Centre for Research in Endocrinology and Reproductive Sciences, University of Health Sciences, Lahore, Pakistan This study was supported by a research grant from the Higher Education Commission, Pakistan Abstract OBJECTIVE: We studied the influence of positive family history (FH) of type 2 diabetes mellitus (T2DM) in Read More
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The impact of the hormonal milieu and stress-associated hypothalamic dopaminergic activation on the rapid compensatory adrenal growth in cycling female rats
Anastasia Sfikakis, Pothitos M. Pitychoutis, Katerina Antoniou, Nikolaos Bikas, Zeta Papadopoulou-Daifoti Department of Experimental Pharmacology, Athens University Medical School, Athens, Greece Abstract OBJECTIVE: We sought to investigate the impact of emotional and surgical stress applied in two hormonally different estrous-cycle phases as well as the hypothalamic dopaminergic involvement on the rapid compensatory adrenal growth (CAG) Read More
Thyroid autoimmunity and miscarriage
Athina Kaprara, Gerasimos E. Krassas Department of Endocrinology, Diabetes and Metabolism, "Panagia" General Hospital, Thessaloniki, Greece Abstract The relation of thyroid autoimmunity to miscarriage is an important issue that has attracted the interest of many investigators. A number of papers have been published so far, which include healthy women, women with recurrent miscarriage and those Read More
Chronic stress, visceral obesity and gonadal dysfunction
Ioannis Kyrou1,2, Constantine Tsigos1 1Endocrinology, Metabolism and Diabetes Unit, Evgenidion Hospital, Athens University Medical School, Athens, Greece, 2Unit for Diabetes and Metabolism, WISDEM, University Hospitals Coventry and Warwickshire, Warwick Medical School, University of Warwick, Coventry, UK Abstract Chronic stress represents a prolonged state of dyshomeostasis caused by intense and frequently imposed stressors. Obesity constitutes a Read More
IMPLICATION OF THE WNT PATHWAY IN THE DIFFERENTIATION AND TRANSFORMATION OF THE THYROID CELL
Sastre-Perona A., Moya C. M., Santisteban P. Fisiopatologia Endocrina y del Sistema Nervioso, CSIC-UAM, Instituto de Investigaciones Biomedicas, Madrid, Spain Abstract Alterations of canonical and non-canonical Wnt pathways have been involved in the development of several epithelial tumours. Therefore the aim of this project was to determine the expression of different members of this pathway Read More
MODULATION OF IODIDE UPTAKE AND RETINOIC ACID RECEPTORS (RAR AND RXR) EXPRESSION BY THYROTROPIN AND RETINOIC ACID
Souza CL.E.1, Coelho M.S.2, Alves M.A.2, Takyia M.Ch.2, Nasciutti L.E.2, Carvalho P.D.1 1Instituto de Biofisica Carlos Chagas Filho, UFRJ, 2Departamento de Histologia e Embriologia, UFRJ Abstract etinoic acid (RA) has been used to reinduce iodide uptake in advanced thyroid cancer, however retinoic acid receptors regulation in thyroid cells has not been well defined. We aimed Read More
NOVEL PEPTIDE ANALOG OF THYROID PEROXIDASE EPITOPE IN AUTOIMMUNE THYROID DISEASES
Shutova I. V., Gribovskaja O.V., Tsyganova O.V., Golubovich V.P. The Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus Abstract Background: Autoimmune thyroid diseases are the most common organ-specific autoimmune diseases. Is established, those diseased as the result of immune systems response on thyroid natural proteins – thyroid peroxidase (TPO), thyreoglobulin and Read More
PREDICTION OF THE LOW-RISK PAPILLARY THYROID CANCER BY A MULTIGENE CLASSIFIER
Szpak-Ulczok S.1, Jarzab M.2, Oczko-Wojciechowska M.1, Kowalska M.1, Kowal M.1, Pfeifer A.1, Czarniecka A.3, Roskosz J.1, Handkiewicz-Junak D.1, Jarzab B.1 1Department of Nuclear Medicine and Endocrine Oncology, 2Clinical Oncology Clinic, 3Clinic of Oncological and Reconstructive Surgery, MSC Memorial Cancer Center and Institute of Oncology, Gliwice Branch Abstract Distant metastasis of papillary thyroid cancer occur in Read More
MEASUREMENT OF BASAL SERUM THYROGLOBULIN (TG) WITH ULTRASENSITIVE ASSAYS ON LEVO-THYROXINE THERAPY (LT4) IN THE FOLLOW-UP OF PATIENTS WITH DIFFERENTIATED THYROID CARCINOMA (DTC): TOO EARLY TO DISMISS THE RHTSH STIMULATION TEST
Castagna M. G., Cipri C., Tala H., Fioravanti C., Pasqui L., Sestini F., Brilli L. Belardini V., Ghezzi M., Pacini F. Department of Internal Medicine, Endocrinology, Metabolism and Biochemistry, Section of Endocrinology and Metabolism, University of Siena, Italy Abstract Recently, two different ultrasensitive serum Tg assays with low functional sensitivity (FS) (0.11 ng/ml Tg Access Read More
RAPAMYCIN TREATMENT IMPAIRS THE PROLIFERATION OF THYROID CARCINOMA CELL LINES IN AN ONCOGENE DEPENDENT MANNER
Rocha A. S.1, Blancquaert S.2, Populo H.3, Faustino A.4, Soares P.5, Roger P.6 1IRIBHM Brussels, Belgium, IPATIMUP, Porto, Portugal, 2IRIBHM, Brussels, Belgium, 3IPATIMUP Porto, Portugal, 4IPATIMUP Porto, Portugal, 5IPATIMUP Porto, Portugal, 6IRIBHM, Brussels, Belgium Abstract mTOR pathway regulates proliferation in several carcinoma models. Rapamycin is a specific inhibitor of Raptor-mTOR complex Predictors of tumour sensitivity Read More