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Sastre-Perona A., Moya C. M., Santisteban P. Fisiopatologia Endocrina y del Sistema Nervioso, CSIC-UAM, Instituto de Investigaciones Biomedicas, Madrid, Spain Abstract Alterations of canonical and non-canonical Wnt pathways have been involved in the development of several epithelial tumours. Therefore the aim of this project was to determine the expression of different members of this pathway Read More

Souza CL.E.1, Coelho M.S.2, Alves M.A.2, Takyia M.Ch.2, Nasciutti L.E.2, Carvalho P.D.1 1Instituto de Biofisica Carlos Chagas Filho, UFRJ, 2Departamento de Histologia e Embriologia, UFRJ Abstract etinoic acid (RA) has been used to reinduce iodide uptake in advanced thyroid cancer, however retinoic acid receptors regulation in thyroid cells has not been well defined. We aimed Read More

Shutova I. V., Gribovskaja O.V., Tsyganova O.V., Golubovich V.P. The Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus Abstract Background: Autoimmune thyroid diseases are the most common organ-specific autoimmune diseases. Is established, those diseased as the result of immune systems response on thyroid natural proteins – thyroid peroxidase (TPO), thyreoglobulin and Read More

Szpak-Ulczok S.1, Jarzab M.2, Oczko-Wojciechowska M.1, Kowalska M.1, Kowal M.1, Pfeifer A.1, Czarniecka A.3, Roskosz J.1, Handkiewicz-Junak D.1, Jarzab B.1 1Department of Nuclear Medicine and Endocrine Oncology, 2Clinical Oncology Clinic, 3Clinic of Oncological and Reconstructive Surgery, MSC Memorial Cancer Center and Institute of Oncology, Gliwice Branch Abstract Distant metastasis of papillary thyroid cancer occur in Read More

Castagna M. G., Cipri C., Tala H., Fioravanti C., Pasqui L., Sestini F., Brilli L. Belardini V., Ghezzi M., Pacini F. Department of Internal Medicine, Endocrinology, Metabolism and Biochemistry, Section of Endocrinology and Metabolism, University of Siena, Italy Abstract Recently, two different ultrasensitive serum Tg assays with low functional sensitivity (FS) (0.11 ng/ml Tg Access Read More

Rocha A. S.1, Blancquaert S.2, Populo H.3, Faustino A.4, Soares P.5, Roger P.6 1IRIBHM Brussels, Belgium, IPATIMUP, Porto, Portugal, 2IRIBHM, Brussels, Belgium, 3IPATIMUP Porto, Portugal, 4IPATIMUP Porto, Portugal, 5IPATIMUP Porto, Portugal, 6IRIBHM, Brussels, Belgium Abstract mTOR pathway regulates proliferation in several carcinoma models. Rapamycin is a specific inhibitor of Raptor-mTOR complex Predictors of tumour sensitivity Read More

Mannavola D.1, Vannucchi G.1, Covelli D.1, Coco P.2, Bertulli R.2, Casali P.2, Beck-Peccoz P.1, Fugazzola L.1 1Department of Medical Sciences, Endocrine Unit, University of Milan, IRCCS Fondazione Policlinico, MIlan, Italy, 2Department of Oncology, Istituto Nazionale dei Tumori, Milan, Italy Abstract Sunitinib is a multitarget inhibitor of tyrosine-kinases used in different human cancers with a high Read More

Blancquaert S.1, Wang L.2, Paternot S.1, Harris Th.2, Roger P.P.1 1IRIBHM, ULB, Campus Erasme, Brussels, Belgium, 2University of Virginia, Department of Pharmacology, USA Abstract In epithelial thyroid cells, phosphorylation of p70 S6K1 is the earliest convergence point between the distinct (co)mitogenic pathways. Whereas the general consensus is that p70 S6K1 phosphorylation is induced by the Read More

Frezzetti D.1, Guerra C.2, Barbacid M.2, Di Lauro R.3, De Vita G.4 1Biogem s.c.a r.l. Ariano Irpino, 2CNIO, Madrid, 3Stazione Zoologica Anton Dohrn Napoli, 4Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II Abstract In cancer microRNAs are often dysregulated with their expression patterns being correlated with clinically relevant tumor characteristics. Read More

Cantara S.1, Capezzone M.1, Marchisotta S.1, Busonero G.1, Filetti S.2, Pacini F.1 1Section of Endocrinology & Metabolism, Department of Internal Medicine, Endocrinology & Metabolism and Biochemistry, University of Siena, Siena, Italy, 2Department of Clinical Sciences, University of Rome, Rome, Italy Abstract Background: Differentiated non-medullary thyroid cancer (NMTC) is mostly sporadic, but the recurrence of familial Read More