John C. Maroulis,1 Constantinos Fourtounas,2 John G. Vlachojannis,2 Nikolaos Siasos,1 Dionysios Karavias,1 Dionysios Chartoumpekis,3 Ioannis Habeos3 1Department of Surgery, 2Department of Internal Medicine-Nephrology, 3Department of Internal Medicine-Endocrinology, Patras University School of Medicine Abstract A 43-year old Caucasian male with end-stage renal disease presented with painful skin lesions and high calcium phosphate product that did not Read More
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The use of insulin sensitising agents in ovulation induction in women with Polycystic Ovary Syndrome
Richard Fleming University of Glasgow and Division of Developmental Medicine, both based at Glasgow Royal Infirmary, G31 2ER, GB Abstract Insulin resistance is an important "upstream" driver for reproductive and metabolic abnormalities in women with Polycystic Ovary Syndrome (PCOS). This theoretical background is now supported by substantial evidence for treating women with PCOS with insulin Read More
Thyroid Nodules 2006: Managing what has been known for over 50 years
Jeffrey R. Garber Division of Endocrinology, Harvard Vanguard Medical Associates, Massachusetts, USA The 50th anniversary of the publication of Mortensen, Woolner and Bennet's paper entitled Gross and microscopic findings in clinically normal thyroid glands has just passed. 1 Their paper reported that at autopsy at the Mayo Clinic approximately half of those not known to Read More
Plasma Interleukin-6 levels, glutathione peroxidase and isoprostane in obese women before and after weight loss. Association with cardiovascular risk factors
Maria Bougoulia, Athanassios Triantos, George Koliakos Biochemistry Department, Aristotele University Medical School, Thessaloniki, Greece Abstract OBJECTIVE: To evaluate the levels of Interleukin-6 (IL-6), glutathione peroxidase and isoprostane in obese women and their association with markers of cardiovascular risk factors before and after weight loss. DESIGN: 36 healthy obese women of reproductive age (group A: age Read More
Changes in prothrombin and activated partial thromboplastin time during replacement therapy with human recombinant growth hormone in growth hormone deficient adults
Dragana Miljic,1 Predrag Miljic,2 Mirjana Doknic,1 Sandra Pekic,1 Marina Djurovic,1 Milica Colovic,2 Vera Popovic1 1Institute of Endocrinology, 2Institute of Hematology, University Clinical Center, Belgrade, Yugoslavia Abstract BACKGROUND: In rodents, Growth Hormone (GH) has been shown to stimulate coagulation parameters, including Prothrombin Time (PT), activated Partial Thromboplastin Time (aPTT) and vitamin K dependent coagulation factors. However, Read More
R831X mutation of the androgen receptor gene in an adolescent with Complete Androgen Insensitivity Syndrome and bilateral testicular hamartomata
Dimitrios G. Goulis,1 Paschalia K. Iliadou,1 Athanasios Papanicolaou,1 Ioannis Georgiou,2 Anthi Chatzikyriakidou,2 Spiridon Gerou,1 Ioannis N. Bontis,1 Ioannis Papadimas1 1Unit of Reproductive Endocrinology, First Department of Obstetrics and Gynecology, Papageorgiou General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece, 2Laboratory of Genetics, Second Department of Obstetrics and Gynecology, University of Ioannina, Ioannina, Greece Abstract An 18-year Read More
A boy with McCune-Albright syndrome associated with GH secreting pituitary microadenoma. Clinical findings and response to treatment
Maria Papadopoulou,1 Sofia Doula,1 Kostas Kitsios,2 Themistoklis Kaltsas,3 Konstantina Kosta1 13rd Department of Paediatrics, Aristotele University of Thessaloniki, Hippocration General Hospital, 21st Department of Internal Medicine, Hippocration General Hospital, 3Department of Endocrinology, Panagia Hospital, Thessaloniki, Greece Abstract The McCune-Albright Syndrome (MAS) is a sporadic rare disease first described in 1936 by McCune and separately by Read More
The diagnosis and differential diagnosis of endogenous Cushing’s syndrome
Polyzois Makras,1 Georgios Toloumis,1 Dimitrios Papadogias,2 Gregory A. Kaltsas,3,4 Michael Besser4 1Department of Endocrinology & Diabetes, 251 Hellenic Air Force General Hospital, Athens, Greece, 2Department of Endocrinology & Diabetes, “IASO” General Hospital, Athens, Greece, 3Department of Pathophysiology, National University of Athens, Athens, Greece, 4Department of Endocrinology, St Bartholomew’s Hospital, London, United Kingdom Abstract Cushing’s syndrome Read More
Improvement of insulin sensitivity in patients with type 2 diabetes mellitus after oral administration of alpha-lipoic acid
Petya Kamenova Department of Diabetology, University Hospital of Endocrinology, Medical University, Sofia, Bulgaria Abstract BACKGROUND: Amelioration of insulin resistance could improve both glycaemic control and cardiovascular risk factors in patients with type 2 diabetes mellitus. Alpha-lipoic acid has been shown to improve insulin action after parenteral administration. OBJECTIVE: the aim of the study was to Read More
Effect of weight loss with or without orlistat treatment on adipocytokines, inflammation, and oxidative markers in obese women
Maria Bougoulia, Athanassios Triantos, George Koliakos Biochemistry Department, Aristoteles University Medical School, Thessaloniki, Greece Abstract OBJECT IVE: T he aim of this study was to evaluate the levels of adipose tissue related hormones, cytokines, and antioxidative substances in obese women before and after intervention with diet alone or with diet plus an inhibitor of gastrointestinental Read More