Dimitris Loutradis,1 Konstantinos Stefanidis,1 Erasmia Kiapekou,2 Evangelia Zapanti,2 Chrisoula Panitsa-Faflia,1 Aristidis Antsaklis1 1First Department of Obstetrics and Gynaecology, Athens University School of Medicine, Alexandra Hospital, 2First Endocrine Section, Alexandra Hospital, Athens, Greece Abstract BACKGROUND: Diethylstilboestrol (DES) exposure in-utero has been shown to have negative effects on pregnancy. DES-exposed women are at increased risk of early Read More
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Nobel prize winner Christian de Duve. From insulin to lysosomes
Jean-Pierre Tricot Catholic University of Leuven (Belgium) “Neglect of the history of medicine sets in motion the dismal cycle of medical science which, turning almost without metabolism, repeatedly brings to light the same material.” Rudolf Virchow, the founder of cell pathology, (1851) (Presented at the Symposium on the History of Diabetes, Delphi, September 7-9, 2005) Read More
Hermaphroditism in Greek and Roman antiquity
George Androutsos Institute of History of Medicine, University Claude Bernard, Lyon, France Abstract Since antiquity hermaphrodites have fascinated the mind and excited the imagination. In this paper, such subjects are discussed as legends about the nativity of Hermaphroditus, son of Hermes and Aphrodite, the social status of these bisexual beings, and their fate in Greek-Roman Read More
Calciphylaxis: a complication of end-stage renal disease improved by parathyroidectomy
John C. Maroulis,1 Constantinos Fourtounas,2 John G. Vlachojannis,2 Nikolaos Siasos,1 Dionysios Karavias,1 Dionysios Chartoumpekis,3 Ioannis Habeos3 1Department of Surgery, 2Department of Internal Medicine-Nephrology, 3Department of Internal Medicine-Endocrinology, Patras University School of Medicine Abstract A 43-year old Caucasian male with end-stage renal disease presented with painful skin lesions and high calcium phosphate product that did not Read More
The use of insulin sensitising agents in ovulation induction in women with Polycystic Ovary Syndrome
Richard Fleming University of Glasgow and Division of Developmental Medicine, both based at Glasgow Royal Infirmary, G31 2ER, GB Abstract Insulin resistance is an important "upstream" driver for reproductive and metabolic abnormalities in women with Polycystic Ovary Syndrome (PCOS). This theoretical background is now supported by substantial evidence for treating women with PCOS with insulin Read More
Thyroid Nodules 2006: Managing what has been known for over 50 years
Jeffrey R. Garber Division of Endocrinology, Harvard Vanguard Medical Associates, Massachusetts, USA The 50th anniversary of the publication of Mortensen, Woolner and Bennet's paper entitled Gross and microscopic findings in clinically normal thyroid glands has just passed. 1 Their paper reported that at autopsy at the Mayo Clinic approximately half of those not known to Read More
Plasma Interleukin-6 levels, glutathione peroxidase and isoprostane in obese women before and after weight loss. Association with cardiovascular risk factors
Maria Bougoulia, Athanassios Triantos, George Koliakos Biochemistry Department, Aristotele University Medical School, Thessaloniki, Greece Abstract OBJECTIVE: To evaluate the levels of Interleukin-6 (IL-6), glutathione peroxidase and isoprostane in obese women and their association with markers of cardiovascular risk factors before and after weight loss. DESIGN: 36 healthy obese women of reproductive age (group A: age Read More
Changes in prothrombin and activated partial thromboplastin time during replacement therapy with human recombinant growth hormone in growth hormone deficient adults
Dragana Miljic,1 Predrag Miljic,2 Mirjana Doknic,1 Sandra Pekic,1 Marina Djurovic,1 Milica Colovic,2 Vera Popovic1 1Institute of Endocrinology, 2Institute of Hematology, University Clinical Center, Belgrade, Yugoslavia Abstract BACKGROUND: In rodents, Growth Hormone (GH) has been shown to stimulate coagulation parameters, including Prothrombin Time (PT), activated Partial Thromboplastin Time (aPTT) and vitamin K dependent coagulation factors. However, Read More
R831X mutation of the androgen receptor gene in an adolescent with Complete Androgen Insensitivity Syndrome and bilateral testicular hamartomata
Dimitrios G. Goulis,1 Paschalia K. Iliadou,1 Athanasios Papanicolaou,1 Ioannis Georgiou,2 Anthi Chatzikyriakidou,2 Spiridon Gerou,1 Ioannis N. Bontis,1 Ioannis Papadimas1 1Unit of Reproductive Endocrinology, First Department of Obstetrics and Gynecology, Papageorgiou General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece, 2Laboratory of Genetics, Second Department of Obstetrics and Gynecology, University of Ioannina, Ioannina, Greece Abstract An 18-year Read More
A boy with McCune-Albright syndrome associated with GH secreting pituitary microadenoma. Clinical findings and response to treatment
Maria Papadopoulou,1 Sofia Doula,1 Kostas Kitsios,2 Themistoklis Kaltsas,3 Konstantina Kosta1 13rd Department of Paediatrics, Aristotele University of Thessaloniki, Hippocration General Hospital, 21st Department of Internal Medicine, Hippocration General Hospital, 3Department of Endocrinology, Panagia Hospital, Thessaloniki, Greece Abstract The McCune-Albright Syndrome (MAS) is a sporadic rare disease first described in 1936 by McCune and separately by Read More