Maria Bougoulia, Athanassios Triantos, George Koliakos Biochemistry Department, Aristotele University Medical School, Thessaloniki, Greece Abstract OBJECTIVE: To evaluate the levels of Interleukin-6 (IL-6), glutathione peroxidase and isoprostane in obese women and their association with markers of cardiovascular risk factors before and after weight loss. DESIGN: 36 healthy obese women of reproductive age (group A: age Read More
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Changes in prothrombin and activated partial thromboplastin time during replacement therapy with human recombinant growth hormone in growth hormone deficient adults
Dragana Miljic,1 Predrag Miljic,2 Mirjana Doknic,1 Sandra Pekic,1 Marina Djurovic,1 Milica Colovic,2 Vera Popovic1 1Institute of Endocrinology, 2Institute of Hematology, University Clinical Center, Belgrade, Yugoslavia Abstract BACKGROUND: In rodents, Growth Hormone (GH) has been shown to stimulate coagulation parameters, including Prothrombin Time (PT), activated Partial Thromboplastin Time (aPTT) and vitamin K dependent coagulation factors. However, Read More
R831X mutation of the androgen receptor gene in an adolescent with Complete Androgen Insensitivity Syndrome and bilateral testicular hamartomata
Dimitrios G. Goulis,1 Paschalia K. Iliadou,1 Athanasios Papanicolaou,1 Ioannis Georgiou,2 Anthi Chatzikyriakidou,2 Spiridon Gerou,1 Ioannis N. Bontis,1 Ioannis Papadimas1 1Unit of Reproductive Endocrinology, First Department of Obstetrics and Gynecology, Papageorgiou General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece, 2Laboratory of Genetics, Second Department of Obstetrics and Gynecology, University of Ioannina, Ioannina, Greece Abstract An 18-year Read More
A boy with McCune-Albright syndrome associated with GH secreting pituitary microadenoma. Clinical findings and response to treatment
Maria Papadopoulou,1 Sofia Doula,1 Kostas Kitsios,2 Themistoklis Kaltsas,3 Konstantina Kosta1 13rd Department of Paediatrics, Aristotele University of Thessaloniki, Hippocration General Hospital, 21st Department of Internal Medicine, Hippocration General Hospital, 3Department of Endocrinology, Panagia Hospital, Thessaloniki, Greece Abstract The McCune-Albright Syndrome (MAS) is a sporadic rare disease first described in 1936 by McCune and separately by Read More
The diagnosis and differential diagnosis of endogenous Cushing’s syndrome
Polyzois Makras,1 Georgios Toloumis,1 Dimitrios Papadogias,2 Gregory A. Kaltsas,3,4 Michael Besser4 1Department of Endocrinology & Diabetes, 251 Hellenic Air Force General Hospital, Athens, Greece, 2Department of Endocrinology & Diabetes, “IASO” General Hospital, Athens, Greece, 3Department of Pathophysiology, National University of Athens, Athens, Greece, 4Department of Endocrinology, St Bartholomew’s Hospital, London, United Kingdom Abstract Cushing’s syndrome Read More
Improvement of insulin sensitivity in patients with type 2 diabetes mellitus after oral administration of alpha-lipoic acid
Petya Kamenova Department of Diabetology, University Hospital of Endocrinology, Medical University, Sofia, Bulgaria Abstract BACKGROUND: Amelioration of insulin resistance could improve both glycaemic control and cardiovascular risk factors in patients with type 2 diabetes mellitus. Alpha-lipoic acid has been shown to improve insulin action after parenteral administration. OBJECTIVE: the aim of the study was to Read More
Effect of weight loss with or without orlistat treatment on adipocytokines, inflammation, and oxidative markers in obese women
Maria Bougoulia, Athanassios Triantos, George Koliakos Biochemistry Department, Aristoteles University Medical School, Thessaloniki, Greece Abstract OBJECT IVE: T he aim of this study was to evaluate the levels of adipose tissue related hormones, cytokines, and antioxidative substances in obese women before and after intervention with diet alone or with diet plus an inhibitor of gastrointestinental Read More
Total parathyroidectomy with autotransplantation in patients with renal hyperparathyroidism: indications and surgical approach
Stavros Gourgiotis, Panagiotis Moustafellos, Charalabos Stratopoulos, Vasilis Vougas, Spiros Drakopoulos, Evangelos Hadjiyannakis First Surgical Department – Organ Transplant Unit, "Evangelismos" General Hospital Athens, Greece Abstract OBJECTIVE: renal hyperparathyroidism (rH) is one of the most serious complications in long-term hemodialysis patients. the purpose of this retrospective study was the evaluation of the surgical indications, parathyroid histology, Read More
Iodine 131 treatment for differentiated thyroid carcinoma in patients with end stage renal failure: dosimetric, radiation safety, and practical considerations
Caliope Alevizaki,1 Michael Molfetas,1 Alexandros Samartzis,1 Barbara Vlassopoulou,2 Charalambos Vassilopoulos,2 Phoedi Rondogianni,3 Sofia Kottou,4 Valsamis Hadjiconstantinou,5 Maria Alevizaki6 1Medical Physics Laboratory, 2Endocrinology Department, 3Nuclear Medicine Department and 5Nephrology Department, Evangelismos Hospital Athens, 4Department of Medical Physics, Athens University School of Medicine and 6Endocrine Unit, Evgenideion Hospital, Athens University School of Medicine Abstract BACKGROUND: Iodine 131 Read More
A novel splicing mutation in exon 4 (456G>A) of the GH1 gene in a patient with congenital isolated growth hormone deficiency
Olga V. Fofanova,1 Oleg V. Evgrafov,2 Alexander V. Polyakov,2 Valentina A. Peterkova,1 Ivan I. Dedov1 1Institute of Pediatric Endocrinology, Endocrinology Research Center, Russian Academy of Medical Sciences, Moscow, 2DNA-Diagnostics Laboratory, Research Center for Medical Genetics, Russian Academy of Medical Sciences, Moscow, Russia Abstract Isolated Growth Hormone Deficiency (IGHD) due to GH1 gene defects has a Read More