Charilaos Stylianou,1 Assimina Galli-Tsinopoulou,1 Dimitrios Farmakiotis,2 Israel Rousso,3 Michael Karamouzis,4 George Koliakos,4 Sanda Nousia-Arvanitakis1 14th Department of Pediatrics, 2Division of Endocrinology and Human Reproduction, 2nd Department of Obstetrics and Gynecology, 32nd Department of Pediatrics, 4Department of Biochemistry, Medical School, Aristotle University of Thessaloniki, Greece Abstract OBJECTIVE: Ghrelin and leptin levels are influenced by body fat Read More
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Recombinant human thyroid stimulating hormone does not acutely change serum osteoprotegerin and soluble receptor activator of nuclear factor-κΒ ligand in patients under evaluation for differentiated thyroid carcinoma*
Massimo Giusti,1 Francesca Cecoli,1 Carla Ghiara,2 Alessandro Rubinacci,3 Isabella Villa,3 Domenico Cavallero,1 Laura Mazzuoli,1 Michele Mussap,2 Roberto Lanzi,3 Francesco Minuto1 1UO Clinica Endocrinologia and 2UO Laboratorio Analisi, 3Azienda Ospedale Università “San Martino”, Genova and UO Diabetologia, Endocrinologia e Malattie Metaboliche, Istituto Scientifico San Raffaele, Milano, Italy Abstract OBJECTIVE: Some extra-thyroid actions of thyroid stimulating hormone (TSH), Read More
Stimulation of the hypothalamic-pituitary-adrenal axis with corticotropin releasing hormone in patients with psoriasis
Evangelos Karanikas, Faidon Harsoulis, Ioannis Giouzepas, Ioannis Griveas Departments of Dermatology, Psychiatry and Endocrinology, Medical School, Aristotle University of Thessaloniki, Greece Abstract OBJECTIVE: Psychocutaneous diseases constitute a large proportion of psychosomatic disorders, with psoriasis being one of the most typical cases. Though alteration of Hypothalamic-Pituitary-Adrenal (HPA) axis function has been suggested as underlying several psychiatric Read More
Ghrelin and the enteroinsular axis in healthy men
Dragan Micic,1 Leonidas Duntas,2,3 Goran Cvijovic,1 Aleksandra Kendereski,1 Mirjana Sumarac-Dumanovic,1 Peter Jehle,3* Svetlana Zoric,1 Danica Pejkovic,1 Mary Lague,3 Carlos Dieguez,4 Felipe Casanueva4 1Institute of Endocrinology, Diabetes and Diseases of Metabolism, Clinical Center of Serbia, Belgrade, Serbia, 2Endocrine Unit, Evgenidion Hospital, University of Athens, Greece, 3Department of Internal Medicine I, University of Ulm, Germany, 4Department of Read More
The alteration of serum soluble CD40 ligand levels in overt and subclinical hypothyroidism
Baris Akinci,1 Abdurrahman Comlekci,1 Serkan Yener,1 Tevfik Demir,1 Firat Bayraktar,1 Faize Yuksel,2 Sena Yesil1 1Division of Endocrinology and Metabolism, 2Division of Haematology, Dokuz Eylul University Medical School, Department of Internal Medicine, Izmir, Turkey Abstract OBJECTIVE: There is controversy as to whether hypothyroidism increases cardiovascular risk. The effect of levothyroxine on the cardiovascular risk profile is Read More
Normal lumbar bone mineral density in optimally treated children and young adolescents with ?-thalassaemia major
Athanasios Christoforidis,1 Eirini Kazantzidou,2 Ioanna Tsatra,1 Haido Tsantali,1 George Koliakos,3 Emmanouil Hatzipantelis,1 George Katzos,1 Miranda Athanassiou-Metaxa1 1Thalassaemia Unit, 1st Paediatric Department, Aristotle University of Thessaloniki, 1Radiology Department Hippokration General Hospital of Thessaloniki, 2Department of Biological Chemistry, Medical School, Aristotle University of Thessaloniki Abstract OBJECTIVE: Osteopenia/osteoporosis of multi-factorial pathogenetic mechanism is reported to be a significant Read More
Tadeus Reichstein, co-winner of the Nobel Prize for Physiology or Medicine: On the occasion of the 110th anniversary of his birth in Poland
Andrzej Wincewicz, Mariola Sulkowska, Stanislaw Sulkowski Departments of Medical and General Pathomorphology, Medical University of Bialystok, Waszyngtona 13, 15-269 Bialystok, Poland Abstract Tadeus Reichstein (1897-1996) was the first scientist born in Poland to receive the Nobel Prize in Medicine or Physiology (1950) for the “discovery of hormones of the adrenal cortex, their structure and biological Read More
Nucleotide excision repair deficiencies and the somatotropic axis in aging
George A. Garinis Department of Genetics, Erasmus Medical Center, Rotterdam, the Netherlands Abstract The physicochemical constitution of DNA cannot warrant lifelong stability. Yet, unlike all other macromolecules, nuclear DNA must last the lifetime of a cell ensuring that its vital genetic information is preserved and faithfully transmitted to progeny. An increasing body of evidence suggests Read More
How diet interacts with longevity genes
Andrzej Bartke, Michael Bonkowski, Michal Masternak Departments of Internal Medicine, Physiology and Pharmacology, Southern Illinois University School of Medicine, Springfield, IL, USA Abstract In laboratory mice, suppression of growth hormone (GH) signaling by spontaneous mutations or targeted disruption of GH- or IGF1-related genes can lead to an impressive increase of longevity. Hypopituitary Ames dwarf (Prop1df) Read More
The GH-IGF1 axis and longevity. The paradigm of IGF1 deficiency
Zvi Laron Endocrinology and Diabetes Research Unit, Schneider Children’s Medical Center of Israel, Petah Tikva, Sackler Faculty of Medicine, Tel Aviv University, Israel Abstract Primary or secondary IGF1 deficiency has been implicated in shortening of lifespan. This paper reviews available data on the influence of IGF1 deficiency on lifespan and longevity in animals and man. Read More