Baris Akinci,1 Abdurrahman Comlekci,1 Serkan Yener,1 Tevfik Demir,1 Firat Bayraktar,1 Faize Yuksel,2 Sena Yesil1 1Division of Endocrinology and Metabolism, 2Division of Haematology, Dokuz Eylul University Medical School, Department of Internal Medicine, Izmir, Turkey Abstract OBJECTIVE: There is controversy as to whether hypothyroidism increases cardiovascular risk. The effect of levothyroxine on the cardiovascular risk profile is Read More
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Normal lumbar bone mineral density in optimally treated children and young adolescents with ?-thalassaemia major
Athanasios Christoforidis,1 Eirini Kazantzidou,2 Ioanna Tsatra,1 Haido Tsantali,1 George Koliakos,3 Emmanouil Hatzipantelis,1 George Katzos,1 Miranda Athanassiou-Metaxa1 1Thalassaemia Unit, 1st Paediatric Department, Aristotle University of Thessaloniki, 1Radiology Department Hippokration General Hospital of Thessaloniki, 2Department of Biological Chemistry, Medical School, Aristotle University of Thessaloniki Abstract OBJECTIVE: Osteopenia/osteoporosis of multi-factorial pathogenetic mechanism is reported to be a significant Read More
Tadeus Reichstein, co-winner of the Nobel Prize for Physiology or Medicine: On the occasion of the 110th anniversary of his birth in Poland
Andrzej Wincewicz, Mariola Sulkowska, Stanislaw Sulkowski Departments of Medical and General Pathomorphology, Medical University of Bialystok, Waszyngtona 13, 15-269 Bialystok, Poland Abstract Tadeus Reichstein (1897-1996) was the first scientist born in Poland to receive the Nobel Prize in Medicine or Physiology (1950) for the “discovery of hormones of the adrenal cortex, their structure and biological Read More
Nucleotide excision repair deficiencies and the somatotropic axis in aging
George A. Garinis Department of Genetics, Erasmus Medical Center, Rotterdam, the Netherlands Abstract The physicochemical constitution of DNA cannot warrant lifelong stability. Yet, unlike all other macromolecules, nuclear DNA must last the lifetime of a cell ensuring that its vital genetic information is preserved and faithfully transmitted to progeny. An increasing body of evidence suggests Read More
How diet interacts with longevity genes
Andrzej Bartke, Michael Bonkowski, Michal Masternak Departments of Internal Medicine, Physiology and Pharmacology, Southern Illinois University School of Medicine, Springfield, IL, USA Abstract In laboratory mice, suppression of growth hormone (GH) signaling by spontaneous mutations or targeted disruption of GH- or IGF1-related genes can lead to an impressive increase of longevity. Hypopituitary Ames dwarf (Prop1df) Read More
The GH-IGF1 axis and longevity. The paradigm of IGF1 deficiency
Zvi Laron Endocrinology and Diabetes Research Unit, Schneider Children’s Medical Center of Israel, Petah Tikva, Sackler Faculty of Medicine, Tel Aviv University, Israel Abstract Primary or secondary IGF1 deficiency has been implicated in shortening of lifespan. This paper reviews available data on the influence of IGF1 deficiency on lifespan and longevity in animals and man. Read More
Thyroid hormones and aging
Robin P. Peeters Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands Abstract With an increase in age, marked changes in thyroid hormone production, metabolism, and action occur. This results in an increased prevalence of (subclinical) thyroid disease in the elderly. In general, subclinical thyroid disease is associated with an increased risk of Read More
Late-onset hypogonadism in men. Experience from the Turku Male Ageing Study (TuMAS)
Ilpo Huhtaniemi1,4, Juuso I. Mäkinen3, Antti Perheentupa1,2, Olli T. Raitakari3 1Department of Physiology, 2Obstetrics and Gynaecology, 3Clinical Physiology, University of Turku, Turku, Finland, 4Department of Reproductive Biology, Imperial College London, London, UK Abstract Interest has arisen during the last 10 years as to the possible connection between the age-related decline in androgen production and symptoms Read More
Autophagy in aging and in neurodegenerative disorders
Yogendra S. Rajawat, Ioannis Bossis University of Maryland, Department of Veterinary Medicine, College Park, Maryland, U.S.A. Abstract Autophagy (ATG) is the process of bulk degradation and recycling of long-lived proteins, macromolecular aggregates, and damaged intracellular organelles. Cellular homeostasis requires continuous removal of worn-out components and replacement with newly synthesized ones. Studies in yeast and other Read More
Enhanced oxidative stress with a gradient between plasma and muscle interstitial fluid in patients with end stage renal failure on hemodialysis
Ioannis Karamouzis,1 Dimitrios Grekas,2 Michael Karamouzis,1 Athanasios Triantos,1 Svetla Vasileva-Staikova,3 Dimitrios Kovachev,4 Afroditi Dimitriadou1 1Biochemistry Laboratory, School of Medicine, University of Thessaloniki, 2First Medical Department, School of Medicine, AHEPA Hospital, Thessaloniki, Greece, 3Clinic of Nephrology and Hemodialysis, Medical University of Varna, 4Biology Laboratory, Medical School, University of Varna, Bulgaria Abstract The concentration of 8-iso-prostaglandin-F2· (8-iso-PGF2α Read More