Eleni Thodou, Theodore Argyrakos, George Kontogeorgos Department of Pathology and Pituitary Tumor Reference Center, G. Gennimatas Athens General Hospital, Athens, Greece Abstract OBJECTIVE: Galectin-3 (Gal-3) belongs to the family of carbohydrate-binding proteins with high affinity for galactoside and is involved in many biological processes including cell growth and differentiation, cell adhesion, tumor progression, apoptosis and Read More
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Oral bisphosphonate adverse effects in 849 patients with metabolic bone diseases
Athanasios D. Anastasilakis, Dimitrios G. Goulis, Marina Kita, Avraam Avramidis Department of Endocrinology, Hippocration General Hospital, Thessaloniki, Greece Abstract OBJECTIVE: Bisphosphonates are potent antiresorptive agents used for a spectrum of metabolic bone diseases. The aim of this study was to compare the adverse effects (AEs) of alendronate, etidronate and risedronate prescribed in a non-selected population, Read More
Cushing\’s syndrome in pregnancy: Report of a case and review of the literature
Marina Kita, Maria Sakalidou, Athanasios Saratzis, Sarris Ioannis, Avraam Avramides Endocrinology Department, Hippocrateio General Hospital, Thessaloniki, Greece Abstract Cushing’s syndrome (CS) during pregnancy is a rare nosology with only a few cases reported in the literature. Misdiagnosis is common, as the syndrome may be easily confused with preeclampsia or gestational diabetes. CS during pregnancy is Read More
Growth hormone deficiency in a patient with autoimmune polyendocrinopathy type 2
Asteroula Papathanasiou, Eleni Kousta, Vasiliki Skarpa, Petros Papachileos, Vasilios Petrou, Charalambos Hadjiathanasiou Endocrine Department, “P & A Kyriakou” Children’s Hospital, Athens, Greece Abstract Autoimmune polyglandular syndrome (APs) type 2 is characterized by the presence of Addison’s disease, in association with autoimmune thyroid disease and/or type 1 diabetes mellitus and is rare in children. A 12.5yr Read More
Thyroid cancer in childhood: Management strategy, including dosimetry and long-term results
Markus Luster,1 Michael Lassmann,1 Lutz S. Freudenberg,2 Christoph Reiners1 1Department of Nuclear Medicine, University of Würzburg, 2Department of Nuclear Medicine, University of Duisburg-Essen, Germany Abstract Thyroid cancer, although very rare in childhood, represents the most common pediatric endocrine neoplasia. The low incidence and the resulting limited availability of prospective, randomized trials lead to a lack Read More
The role of the Wnt signaling pathway in osteoblast commitment and differentiation
Maria P. Yavropoulou,1 John G. Yovos2 1Research Fellow in Endocrinology and Metabolism, 2Professor of Endocrinology and Metabolism, Aristotle University of Thessaloniki, AHEPA University Hospital, Thessaloniki, Greece Abstract Wnts are a large family of proteins that participate in an array of cellular biological processes such as embryogenesis, organogenesis and tumor formation. These proteins bind to membrane Read More
Ghrelin and leptin levels in obese adolescents. Relationship with body fat and insulin resistance
Charilaos Stylianou,1 Assimina Galli-Tsinopoulou,1 Dimitrios Farmakiotis,2 Israel Rousso,3 Michael Karamouzis,4 George Koliakos,4 Sanda Nousia-Arvanitakis1 14th Department of Pediatrics, 2Division of Endocrinology and Human Reproduction, 2nd Department of Obstetrics and Gynecology, 32nd Department of Pediatrics, 4Department of Biochemistry, Medical School, Aristotle University of Thessaloniki, Greece Abstract OBJECTIVE: Ghrelin and leptin levels are influenced by body fat Read More
Recombinant human thyroid stimulating hormone does not acutely change serum osteoprotegerin and soluble receptor activator of nuclear factor-κΒ ligand in patients under evaluation for differentiated thyroid carcinoma*
Massimo Giusti,1 Francesca Cecoli,1 Carla Ghiara,2 Alessandro Rubinacci,3 Isabella Villa,3 Domenico Cavallero,1 Laura Mazzuoli,1 Michele Mussap,2 Roberto Lanzi,3 Francesco Minuto1 1UO Clinica Endocrinologia and 2UO Laboratorio Analisi, 3Azienda Ospedale Università “San Martino”, Genova and UO Diabetologia, Endocrinologia e Malattie Metaboliche, Istituto Scientifico San Raffaele, Milano, Italy Abstract OBJECTIVE: Some extra-thyroid actions of thyroid stimulating hormone (TSH), Read More
Stimulation of the hypothalamic-pituitary-adrenal axis with corticotropin releasing hormone in patients with psoriasis
Evangelos Karanikas, Faidon Harsoulis, Ioannis Giouzepas, Ioannis Griveas Departments of Dermatology, Psychiatry and Endocrinology, Medical School, Aristotle University of Thessaloniki, Greece Abstract OBJECTIVE: Psychocutaneous diseases constitute a large proportion of psychosomatic disorders, with psoriasis being one of the most typical cases. Though alteration of Hypothalamic-Pituitary-Adrenal (HPA) axis function has been suggested as underlying several psychiatric Read More
Ghrelin and the enteroinsular axis in healthy men
Dragan Micic,1 Leonidas Duntas,2,3 Goran Cvijovic,1 Aleksandra Kendereski,1 Mirjana Sumarac-Dumanovic,1 Peter Jehle,3* Svetlana Zoric,1 Danica Pejkovic,1 Mary Lague,3 Carlos Dieguez,4 Felipe Casanueva4 1Institute of Endocrinology, Diabetes and Diseases of Metabolism, Clinical Center of Serbia, Belgrade, Serbia, 2Endocrine Unit, Evgenidion Hospital, University of Athens, Greece, 3Department of Internal Medicine I, University of Ulm, Germany, 4Department of Read More