Wilmar M. Wiersinga Department of Endocrinology & Metabolism, Academic Medical Center, University of Amsterdam, the Netherlands Abstract Thyroid nodules in childhood and adolescence are less prevalent but more often malignant than in adulthood. Malignant nodules are predominantly papillary cancers; benign nodules are mostly solid colloid nodules/adenomas, but can be cystic or due lymphocytic thyroiditis. Previous Read More
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Differentiated thyroid cancer in children and adults: same or distinct disease?
Barbara Jarzab, Daria Handkiewicz-Junak Department of Nuclear Medicine and Endocrine Oncology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland Abstract Differentiated thyroid cancer (Dtc) is a rare disease, especially in children. Differences in the biology and clinical course of Dtc in children, when compared with adults, may be related both Read More
Early onset adiposity: A pathway to polycystic ovary syndrome in adolescents?
Evanthia Diamanti-Kandarakis, Charikleia D. Christakou, Eleni Kandaraki, Krystallenia I. Alexandraki First Department of Medicine, Endocrine Section, Athens University School of Medicine, Athens, Greece Abstract Polycystic Ovary Syndrome is a heterogenous syndrome of unknown causation commonly associated with obesity. Τhe particular timing of the onset of obesity may be important, since the earlier the onset of Read More
Contribution of endocrine parameters in predicting outcome of multiple trauma patients in an intensive care unit
Ioannis Ilias1, Konstantinos Stamoulis2, Apostolos Armaganidis2, Panagiotis Lyberopoulos2, Marinella Tzanela3, Stylianos Orfanos2, Maria Theodorakopoulou2, Stylianos Tsagarakis4, Ioanna Dimopoulou2 1Department of Endocrinology, Elena Venizelou Hospital, 2Second Department of Critical Care Medicine, Attikon Hospital, Athens University School of Medicine, 3Department of Endocrinology, Evangelismos Hospital, and 4Department of Endocrinology, Athens Polyclinic, Athens, Greece Abstract OBJECTIVE: To evaluate whether Read More
Galectin-3 as a marker distinguishing functioning from silent corticotroph adenomas
Eleni Thodou, Theodore Argyrakos, George Kontogeorgos Department of Pathology and Pituitary Tumor Reference Center, G. Gennimatas Athens General Hospital, Athens, Greece Abstract OBJECTIVE: Galectin-3 (Gal-3) belongs to the family of carbohydrate-binding proteins with high affinity for galactoside and is involved in many biological processes including cell growth and differentiation, cell adhesion, tumor progression, apoptosis and Read More
Oral bisphosphonate adverse effects in 849 patients with metabolic bone diseases
Athanasios D. Anastasilakis, Dimitrios G. Goulis, Marina Kita, Avraam Avramidis Department of Endocrinology, Hippocration General Hospital, Thessaloniki, Greece Abstract OBJECTIVE: Bisphosphonates are potent antiresorptive agents used for a spectrum of metabolic bone diseases. The aim of this study was to compare the adverse effects (AEs) of alendronate, etidronate and risedronate prescribed in a non-selected population, Read More
Cushing\’s syndrome in pregnancy: Report of a case and review of the literature
Marina Kita, Maria Sakalidou, Athanasios Saratzis, Sarris Ioannis, Avraam Avramides Endocrinology Department, Hippocrateio General Hospital, Thessaloniki, Greece Abstract Cushing’s syndrome (CS) during pregnancy is a rare nosology with only a few cases reported in the literature. Misdiagnosis is common, as the syndrome may be easily confused with preeclampsia or gestational diabetes. CS during pregnancy is Read More
Growth hormone deficiency in a patient with autoimmune polyendocrinopathy type 2
Asteroula Papathanasiou, Eleni Kousta, Vasiliki Skarpa, Petros Papachileos, Vasilios Petrou, Charalambos Hadjiathanasiou Endocrine Department, “P & A Kyriakou” Children’s Hospital, Athens, Greece Abstract Autoimmune polyglandular syndrome (APs) type 2 is characterized by the presence of Addison’s disease, in association with autoimmune thyroid disease and/or type 1 diabetes mellitus and is rare in children. A 12.5yr Read More
Thyroid cancer in childhood: Management strategy, including dosimetry and long-term results
Markus Luster,1 Michael Lassmann,1 Lutz S. Freudenberg,2 Christoph Reiners1 1Department of Nuclear Medicine, University of Würzburg, 2Department of Nuclear Medicine, University of Duisburg-Essen, Germany Abstract Thyroid cancer, although very rare in childhood, represents the most common pediatric endocrine neoplasia. The low incidence and the resulting limited availability of prospective, randomized trials lead to a lack Read More
The role of the Wnt signaling pathway in osteoblast commitment and differentiation
Maria P. Yavropoulou,1 John G. Yovos2 1Research Fellow in Endocrinology and Metabolism, 2Professor of Endocrinology and Metabolism, Aristotle University of Thessaloniki, AHEPA University Hospital, Thessaloniki, Greece Abstract Wnts are a large family of proteins that participate in an array of cellular biological processes such as embryogenesis, organogenesis and tumor formation. These proteins bind to membrane Read More