Niki Papavramidou, Helen Christopoulou-Aletra Department of History of Medicine, Aristotle University School of Medicine, Thessaloniki, Greece The term diabetes first appears in a text by Aretaeus to describe a disease of the kidneys. Galen is likely to have borrowed this term from Aretaeus also to describe the same disorder, though in a manner somewhat uncharacteristic Read More
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The spectrum of phytoestrogens in nature: our knowledge is expanding
Paraskevi Moutsatsou Department of Biological Chemistry, Athens University Medical School, Athens, Greece Abstract The classical phytoestrogens, so far known, constitute a group of plant-derived compounds which include mainly isoflavones, lignans, coumestanes, stilbenes and the flavonoids quercetin and kaempherol. The discovery of many more novel estrogen-like compounds in the plant kingdom demonstrates that the spectrum of Read More
Brunner?s missing ?Aha experience? delayed progress in diabetes research by 200 years
Fritz S. Keck1, Leonidas H. Duntas2 1Westkuestenklinikum Heide, Germany, 2Evgenidion Hospital, Athens University School of Medice, Athens, Greece Abstract In 1889, the pancreatectomy performed on a dog by Joseph von Mehring and Oskar Minkowski led to the discovery of the pancreatic origin of diabetes disease. Already 200 years before, Johann Conrad Brunner had successfully performed Read More
Management of thyroid nodules in children and adolescents
Wilmar M. Wiersinga Department of Endocrinology & Metabolism, Academic Medical Center, University of Amsterdam, the Netherlands Abstract Thyroid nodules in childhood and adolescence are less prevalent but more often malignant than in adulthood. Malignant nodules are predominantly papillary cancers; benign nodules are mostly solid colloid nodules/adenomas, but can be cystic or due lymphocytic thyroiditis. Previous Read More
Differentiated thyroid cancer in children and adults: same or distinct disease?
Barbara Jarzab, Daria Handkiewicz-Junak Department of Nuclear Medicine and Endocrine Oncology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland Abstract Differentiated thyroid cancer (Dtc) is a rare disease, especially in children. Differences in the biology and clinical course of Dtc in children, when compared with adults, may be related both Read More
Early onset adiposity: A pathway to polycystic ovary syndrome in adolescents?
Evanthia Diamanti-Kandarakis, Charikleia D. Christakou, Eleni Kandaraki, Krystallenia I. Alexandraki First Department of Medicine, Endocrine Section, Athens University School of Medicine, Athens, Greece Abstract Polycystic Ovary Syndrome is a heterogenous syndrome of unknown causation commonly associated with obesity. Τhe particular timing of the onset of obesity may be important, since the earlier the onset of Read More
Contribution of endocrine parameters in predicting outcome of multiple trauma patients in an intensive care unit
Ioannis Ilias1, Konstantinos Stamoulis2, Apostolos Armaganidis2, Panagiotis Lyberopoulos2, Marinella Tzanela3, Stylianos Orfanos2, Maria Theodorakopoulou2, Stylianos Tsagarakis4, Ioanna Dimopoulou2 1Department of Endocrinology, Elena Venizelou Hospital, 2Second Department of Critical Care Medicine, Attikon Hospital, Athens University School of Medicine, 3Department of Endocrinology, Evangelismos Hospital, and 4Department of Endocrinology, Athens Polyclinic, Athens, Greece Abstract OBJECTIVE: To evaluate whether Read More
Galectin-3 as a marker distinguishing functioning from silent corticotroph adenomas
Eleni Thodou, Theodore Argyrakos, George Kontogeorgos Department of Pathology and Pituitary Tumor Reference Center, G. Gennimatas Athens General Hospital, Athens, Greece Abstract OBJECTIVE: Galectin-3 (Gal-3) belongs to the family of carbohydrate-binding proteins with high affinity for galactoside and is involved in many biological processes including cell growth and differentiation, cell adhesion, tumor progression, apoptosis and Read More
Oral bisphosphonate adverse effects in 849 patients with metabolic bone diseases
Athanasios D. Anastasilakis, Dimitrios G. Goulis, Marina Kita, Avraam Avramidis Department of Endocrinology, Hippocration General Hospital, Thessaloniki, Greece Abstract OBJECTIVE: Bisphosphonates are potent antiresorptive agents used for a spectrum of metabolic bone diseases. The aim of this study was to compare the adverse effects (AEs) of alendronate, etidronate and risedronate prescribed in a non-selected population, Read More
Cushing\’s syndrome in pregnancy: Report of a case and review of the literature
Marina Kita, Maria Sakalidou, Athanasios Saratzis, Sarris Ioannis, Avraam Avramides Endocrinology Department, Hippocrateio General Hospital, Thessaloniki, Greece Abstract Cushing’s syndrome (CS) during pregnancy is a rare nosology with only a few cases reported in the literature. Misdiagnosis is common, as the syndrome may be easily confused with preeclampsia or gestational diabetes. CS during pregnancy is Read More