Andrzej Bartke, Michael Bonkowski, Michal Masternak Departments of Internal Medicine, Physiology and Pharmacology, Southern Illinois University School of Medicine, Springfield, IL, USA Abstract In laboratory mice, suppression of growth hormone (GH) signaling by spontaneous mutations or targeted disruption of GH- or IGF1-related genes can lead to an impressive increase of longevity. Hypopituitary Ames dwarf (Prop1df) Read More
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The GH-IGF1 axis and longevity. The paradigm of IGF1 deficiency
Zvi Laron Endocrinology and Diabetes Research Unit, Schneider Children’s Medical Center of Israel, Petah Tikva, Sackler Faculty of Medicine, Tel Aviv University, Israel Abstract Primary or secondary IGF1 deficiency has been implicated in shortening of lifespan. This paper reviews available data on the influence of IGF1 deficiency on lifespan and longevity in animals and man. Read More
Thyroid hormones and aging
Robin P. Peeters Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands Abstract With an increase in age, marked changes in thyroid hormone production, metabolism, and action occur. This results in an increased prevalence of (subclinical) thyroid disease in the elderly. In general, subclinical thyroid disease is associated with an increased risk of Read More
Late-onset hypogonadism in men. Experience from the Turku Male Ageing Study (TuMAS)
Ilpo Huhtaniemi1,4, Juuso I. Mäkinen3, Antti Perheentupa1,2, Olli T. Raitakari3 1Department of Physiology, 2Obstetrics and Gynaecology, 3Clinical Physiology, University of Turku, Turku, Finland, 4Department of Reproductive Biology, Imperial College London, London, UK Abstract Interest has arisen during the last 10 years as to the possible connection between the age-related decline in androgen production and symptoms Read More
Autophagy in aging and in neurodegenerative disorders
Yogendra S. Rajawat, Ioannis Bossis University of Maryland, Department of Veterinary Medicine, College Park, Maryland, U.S.A. Abstract Autophagy (ATG) is the process of bulk degradation and recycling of long-lived proteins, macromolecular aggregates, and damaged intracellular organelles. Cellular homeostasis requires continuous removal of worn-out components and replacement with newly synthesized ones. Studies in yeast and other Read More
Enhanced oxidative stress with a gradient between plasma and muscle interstitial fluid in patients with end stage renal failure on hemodialysis
Ioannis Karamouzis,1 Dimitrios Grekas,2 Michael Karamouzis,1 Athanasios Triantos,1 Svetla Vasileva-Staikova,3 Dimitrios Kovachev,4 Afroditi Dimitriadou1 1Biochemistry Laboratory, School of Medicine, University of Thessaloniki, 2First Medical Department, School of Medicine, AHEPA Hospital, Thessaloniki, Greece, 3Clinic of Nephrology and Hemodialysis, Medical University of Varna, 4Biology Laboratory, Medical School, University of Varna, Bulgaria Abstract The concentration of 8-iso-prostaglandin-F2· (8-iso-PGF2α Read More
Serum transforming growth factor-beta 1 levels in normoalbuminuric and normotensive patients with type 2 diabetes. Effect of metformin and rosiglitazone
Serkan Yener,1 Abdurrahman Comlekci,1 Baris Akinci,1 Pinar Akan,2 Tevfik Demir,1 Firat Bayraktar,1 Sena Yesil1 1Dokuz Eylul University, Department of Internal Medicine, Division of Endocrinology and Metabolism, 2Dokuz Eylul University, Department of Biochemistry, Izmir, Turkey Abstract OBJECTIVE: a)To determine serum Transforming Growth Factor-beta 1 (TGF-β1) levels in patients with type 2 diabetes who do not have Read More
A female infant with Silver Russell Syndrome, mesocardia and enlargement of the clitoris
Assimina Galli-Tsinopoulou,1 Eleftheria Emmanouilidou,1 Paraskevi Karagianni,2 Maria Grigoriadou,3 John Kirkos,4 George S. Varlamis1 14th Department of Pediatrics, 22nd Neonatal Intensive Care Unit and Neonatology Department, Medical School, Aristotle University of Thessaloniki, 3Department of Genetics, Institute of Child Health, Athens, 43rd Orthopaedic Department, Medical School, Aristotle University of Thessaloniki, Greece Abstract Silver Russell Syndrome (SRS) is Read More
The length of life and eugeria in classical Greece
Menelaos L. Batrinos Emeritus Professor of Endocrinology Abstract Contrary to the commonly held belief that in antiquity and as late as 1700 A.D. normal lifespan was about 35 years, there are indications that the ancient Greeks lived longer. In a study of all men of renown, living in the 5th and 4th century in Greece, Read More
Early-life events. Effects on aging
Eero Kajantie National Public Health Institute, Helsinki, Finland Abstract During the last two decades, a considerable body of evidence has emerged showing that circumstances during the fetal period and childhood may have lifelong programming effects on different body functions with a considerable impact on disease susceptibility. From a medical point of view, these long-term effects Read More