Evangeline Vassilatou1, Panayiotis Schinochoritis2, Stamatina Marioli3, Ioanna Tzavara1 1Department of Endocrinology, Diabetes and Metabolism, 2Biomedicine International Diagnostic Services and 3Department of Biochemistry, "Amalia Fleming" General Hospital, Athens, Greece Abstract A 21-year old man, complaining of headaches and fatigue, with a negative past medical history and a normal clinical examination, underwent a hormonal investigation which revealed Read More
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The Hippocratic Spirit
George K. Daikos Amphiarion Foundation of Chemotherapeutic Studies, Athens Greece The Hippocratic medical school (the medical school of Kos) was not an isolated phenomenon but the evolution and consequence of previous ideas and practices derived from many older sources. Hippocratic medicine1-3 replaced the theurgical and hieratic medicine, succeeding to and evolving from the medicine of Read More
Growth Management of Children and Adolescents with Cushing\’s Disease
In this issue, Savage et al., summarize and discuss their data and those of the literature on the growth management of pediatric patients with Cushing's disease1. Endogenous Cushing's syndrome is rare in all ages and children and adolescents represent about 10 percent of the total2. The effect of hypercortisolism on growth is profound and proportional Read More
Macroprolactinemia: an unnoticeable factor
Hyperprolactinemia most commonly results from physiologic or pathologic conditions that cause hypersecretion of PRL by lactotroph cells. Physiologic causes include pregnancy and lactation while pathologic hyperprolactinemia may result from a lactotroph adenoma or from several readily identifiable causes that may interfere with normal dopamine inhibition of PRL secretion. However, in some patients whose serum PRL Read More
Growth and growth hormone secretion in paediatric Cushing\’s disease
Martin O. Savage1, Helen L. Storr1, Ashley B. Grossman1, Gerasimos E. Krassas2 1Department of Endocrinology, St Bartholomew's and The Royal London School of Medicine and Dentistry, London, UK, 2Department of Endocrinology and Metabolism, Panagia General Hospital, Thessaloniki, Greece Abstract Although paediatric Cushing's disease is rare, it is associated with severe morbidity in childhood and presents Read More
Magnetization transfer imaging of the pituitary gland
Maria I. Argyropoulou1, Dimitrios Nikiforos Kiortsis2 1Department of Radiology, Medical School University of Ioannina, 2Department of Physiology, Medical School University of Ioannina, Ioannina, Greece Abstract Magnetization transfer (MT) techniques provide tissue contrast which depends mainly on the concentration of macromolecules. The magnetization transfer phenomenon is determined by the restricted macromolecular protons and is quantified by Read More
The influence of exercise on growth hormone and testosterone in prepubertal and early-pubertal boys
Charilaos Tsolakis1, Paraskevi Xekouki2, Socratis Kaloupsis1, Dimitrios Karas1, Dimosthenis Messinis1, George Vagenas1, Athanasios Dessypris3 1Department of Physical Education and Sports Science, Athens University, 2Endocrine unit, First Dept of Pediatrics Athens University School of Medicine, 3Department of Biochemistry and Molecular Biology, Athens University, School of Biology, Athens, Greece Abstract The purpose of this study was two Read More
Transient Congenital Hypothyroidism due to maternal autoimmune thyroid disease
Chryssanthi Mengreli1, Maria Maniati-Christidi2, Christina Kanaka-Gantenbein2, Panagiotis Girginoudis1, Apostolos G. Vagenakis3, Catherine Dacou-Voutetakis2 1Institute of Child Health, Athens, 2First Dept. of Pediatrics, Athens University, School of Medicine, Athens, and 3Dept. of Medicine, Division of Endocrinology, University of Patras, Patras, Greece Abstract The neonatal screening program for congenital hypothyroidism (CH) in Greece shows an overall incidence Read More
Laron syndrome. First report from Greece
Assimina Galli-Tsinopoulou1, Sanda Nousia-Arvanitakis1, Ioannis Tsinopoulos2, Christos Bechlivanides1, Orit Shevah3, Zvi Laron3 1Fourth Pediatric Department, 2Clinic of Ophthalmology of Aristotle University of Thessaloniki, Thessaloniki, Greece, 3Endocrinology and Diabetes Research Unit, Schneider Children's Medical Center, Petah-Tikva, Israel Abstract Laron-type dwarfism is an autosomal recessive disorder caused by deletions or mutations of the growth hormone receptor gene. Read More
Hypoglycaemia secondary to the secretion of pro-insulin like growth factor ii by a metastatic neuroendocrine tumour with sarcomatous differentiation
Mia Morgan, Alexandra Nanzer, Cecilia Camacho-Hubner, Gregory A. Kaltsas, John P. Monson Department of Endocrinology, St Bartholomew's Hospital, London EC1A 7BE, UK Abstract A patient presented with frequent episodes of spontaneous hypoglycaemia due to a disseminated neuroendocrine tumour with sarcomatous differentiation, secreting incompletely processed pro-insulin-like growth factor II (pro-IGF-II). Although the combination of GH and Read More