Nicos Skordis, Eleana Ferrari, Aria Antoniadou, Leonidas A. Phylactou, Pavlos Fanis, Vassos Neocleous
This case report describes a 47,XXX girl who presented very early, at the age of 14 months, with signs of sexual precocity (breast and pubic hair development, menarche) and was finally diagnosed with GnRH dependent precocious puberty with no evidence of underlying central nervous system pathology. Molecular testing did not identify any genetic defect in any of the genes tested …
Carlo Gobitti, Alessandro Sindoni, Chiara Bampo, Tanja Baresic, Giorgio Giorda, Lara Alessandrini, Vincenzo Canzonieri, Giovanni Franchin, Eugenio Borsatti
Struma ovarii (SO), a rare tumor containing at least 50% of thyroid tissue, represents approximately 5% of all ovarian teratomas; its malignant transformation rate is reported to occur in up to 10% of cases and metastases occur in about 5-6% of them. We describe a 36-year old woman who underwent laparoscopic left annessectomy two years earlier because of an ovarian cyst. Follow-up imaging revealed a right adnexal mass, ascitis and peritoneal nodes that were diagnosed as comprising a malignant …
Konstantinos Laios
Dear Editor, The earliest physiological description of the Pineal (Latin: pinea = pinecone) Gland (also occasionally “conarium”, from the Greek: κωνάριο = κώνος = cone, pinecone) is found in two medical works written by Galen (2nd c. AD) (Figure 1). These works contain its anatomical description …
Nilufer Ozdemir Kutbay, Mustafa Berker, Figen Soylemezoglu, Hatice Ozisik, Banu Sarer Yurekli
Dear Sir, Hypophysitis is a rare disease of the pituitary gland whose incidence is 1 case per 9 million people per year. Hypophysitis, which can be categorized as primary (idiopathic) hypophysitis and secondary hypophysitis, may develop through systemic inflammatory disorders such as tuberculosis, Wegener’s granulomatosis and sarcoidosis. Based on histologic features …
Anastasia K. Armeni, Danai Georgakopoulou, Georgios K. Markantes, Konstantina Barouti, Leonidas Liarakos, Vasiliki Vasileiou, Neoklis A. Georgopoulos
In Ancient Greece, up to the Classical era, hermaphrodites were regarded as “monstrous” beings, messengers of evil or a sign of divine anger. They were consequently socially marginalized, being treated cruelly or even put to death …