Issue 1 (January- March)151 – Page 2

Prevalence and determinants of type 2 diabetes mellitus in a Greek adult population

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Sofia Tsirona, Fotis Katsaros, Alexandra Bargiota, Stergios A. Polyzos, George Arapoglou, George N. Koukoulis

The prevalence of diabetes mellitus (DM) is increasing worldwide reaching epidemic proportions. The aim of the present study was to estimate the prevalence of DM in Thessaly, a large region of Central Greece, and to extrapolate our results to the population of the entire country. A random sample of 805 adults (421 females and 384 men) living in Thessaly, aged 18-80 years, was surveyed. After completing a questionnaire about health status and a thorough physical examination …

The relationship between retinol-binding protein 4 and apolipoprotein B-containing lipoproteins is attenuated in patients with very high serum triglycerides: A pilot study

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Georgios A. Christou, Constantinos C. Tellis, Moses S. Elisaf, Alexandros D. Tselepis, Dimitrios N. Kiortsis

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OBJECTIVE: The investigation of the association between retinol-binding protein 4 (RBP4)and lipoproteins in subjects with hypertriglyceridemia. DESIGN: Forty-six obese or overweight hypertriglyceridemic patients were studied at baseline and 20 of them underwent a hypocaloric low-fat diet for 3 months …

Clinical and biochemical responses after Gamma Knife surgery for a dopamine-secreting paraganglioma: case report

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Constantin Tuleasca, Yves Jaquet, Valerie Schweizer, Laura Negretti, Vera Magaddino, Philippe Maeder, Karim-Alexandre Abid, Benoit Lhermitte, Eric Grouzmann, Marc Levivier

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INTRODUCTION: The efficacy of Gamma Knife surgery (GKS) in local tumor control of non-secreting paragangliomas (PGLs) has been fully described by previous studies. However, with regard to secreting PGL, only one previous case report exists advocating its efficacy at a biological level. CASE REPORT: The aims of this study were: 1) to evaluate the safety/efficacy of GKS in a dopamine-secreting …

Multiple endocrine neoplasia type 1 associated with a new germline Men1 mutation in a family with atypical tumor phenotype

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Nikolaos Perakakis, Felix Flohr, Gian Kayser, Oliver Thomusch, Lydia Parsons, Franck Billmann, Ernst von Dobschuetz, Susanne Rondot, Jochen Seufert, Katharina Laubner

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BACKGROUND: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal-dominant hereditary disorder associated with the development of endocrine tumors due to reduced expression of the tumor suppressor protein menin. Recent studies indicate a general role of menin in carcinogenesis, affecting the prevalence and clinical course of common non-endocrine tumors such as breast cancer, hepatocellular carcinoma and melanoma. Here we report a new germline missense mutation …

Intractable hypoglycaemia in a patient with advanced carcinoid syndrome successfully treated with hepatic embolization

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Angelos Kyriacou, Was Mansoor, Jeremy Lawrance, Peter J. Trainer

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A male patient presented at the age of 54 years with metastatic pancreatic neuroendocrine tumour (NET). He was managed with interferon and multiple courses of MIBG therapy which controlled his disease for about seven years. He then developed symptomatic hypoglycaemia which resolved with the introduction of somatostatin analogue treatment and further therapeutic MIBG. However, three years later he was admitted to hospital with severe and intractable hypoglycaemia …

TSH-secreting pituitary adenomas treated by gamma knife radiosurgery: our case experience and a review of the literature

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Zadalla Mouslech, Maria Somali, Anastasia Konstantina Sakali, Christos Savopoulos, George Mastorakos, Apostolos I. Hatzitolios

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A 43-year-old woman, previously misdiagnosed as having primary hyperthyroidism and treated with antithyroid drugs, presented to us with overt hyperthyroidism, high levels of thyroid hormones and elevated thyroid-stimulating hormone (TSH). Μagnetic resonance imaging (MRI) revealed a pituitary microadenoma extending suprasellarly. The patient responded favorably to initial treatment with somatostatin analogs for 2 years but due to the escape phenomenon, TSH levels escalated and hyperthyroidism relapsed …

Identification of a novel mutation of the PRKAR1A gene in a patient with Carney complex with significant osteoporosis and recurrent fractures

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Labrini Papanastasiou, Stelios Fountoulakis, Nikos Voulgaris, Theodora Kounadi, Theodosia Choreftaki, Akrivi Kostopoulou, George Zografos, Charalampos Lyssikatos, Constantine A. Stratakis, George Piaditis

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OBJECTIVE: Carney complex (CNC) is a rare autosomal dominant multiple neoplasia syndrome characterized by the presence of endocrine and non-endocrine tumors. More than 125 different germline mutations of the protein Kinase A type 1-α regulatory subunit (PRKAR1A) gene have been reported. We present a novel PRKAR1A gene germline mutation in a patient with severe osteoporosis and recurrent vertebral fractures. DESIGN: Clinical case report …

Landmarks in the history of adrenal surgery

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Marios Papadakis, Andreas Manios, Georgios Schoretsanitis, Constantinos Trompoukis

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The last 100 years have seen a revolution in the understanding of adrenal disease and its surgical treatment. The isolation of its hormones, the detailed study of the adrenal medulla and the cortex together with the enormous expansion of surgical methods served as catalysts to this revolution. The Greek word for adrenal (epinephridio, from the Greek epi, upon, and nephros, kidney) dates back to the age of Homer who mentions the adrenal glands …

Does ambient light at night reduce total melatonin production?

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Christopher C.M. Kyba, Thomas Kantermann

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It was with great interest that we read the recent study by Hersh et al. on the effects of sleep and light at night on melatonin in adolescents. Of particular interest was their focus on electronic use after “lights out”. The authors highlight the importance of understanding what effects this may have on sleep, citing a survey that showed that 72% of American 13-18 year olds regularly use a cellphone or computer before trying to go to sleep …

Central precocious puberty due to hypothalamic hamartoma in neurofibromatosis type 1

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Emanuele Bartolini, Stefano Stagi, Perla Scalini, Andrea Bianchi, Antonio Ciccarone, Mario Mascalchi

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In neurofibromatosis type 1 (NF1), Central Precocious Puberty (CPP) occurs almost invariably in association with optic pathway tumors, usually pilocytic astrocytoma. However, at times the aetiology remains. On the other hand, in the general population CPP develops due to an underlying hypothalamic hamartoma in up to 10% of patients. To the best of our knowledge, CPP due to hypothalamic hamartomas in NF1 has been reported only once in the literature …