Mubarak Al-Gahtany1, Eva Horvath2, Kalman Kovacs3 1Department of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada, 2&3 Department of Laboratory Medicine, St. Michael Hospital, University of Toronto, Toronto, Ontario, Canada Abstract Pituitary hyperplasia is rare, difficult to diagnose and sometimes controversial. The hyperplasia could be physiologic which is usually reversible, or pathologic which Read More
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Cancer in the thyroid is not always thyroid cancer
Katherine E. Akester1, Noel Somasundaram1, Salvador Diaz-Cano2, Ashley B. Grossman1 Departments of 1Endocrinology and 2Histopathology, St. Bartholomew's Hospital, London EC1A 7BE, UK Abstract Most clinicians assume that a thyroid mass which appears to be malignant is most likely a tumour arising from thyroid cells. We present a case where the thyroid malignancy was associated with Read More
The significance of the number seven in ancient Greece and its relation to Endocrinology
Menalaos L. Batrinos Athens, University School of medicine Athens, Greece Many ancients held various beliefs about the supernatural virtues of certain numbers. In ancient Greece, the school of Pythagoras (590 BC) taught the doctrine of the numerical essence of natural events. In accordance with this theory, the number 7 was considered a sacred number and Read More
A short history of the thyroid gland
V. Leoutsakos Dept of Surgery Athens University School of Medicine, Athens, 115 27 Greece Goiter is very common in many parts of the world and was recognized long before the thyroid gland itself. Since prehistoric times, the visible outgrowths in the front of the neck have been objects of curiosity and study. Their nature, appearance, Read More
Genetic Testing in Clinical Endocrinology
Constantin Polychronakos Endocrine Genetics Laboratory, McGill University Health Center (Children's Hospital), Montréal, Québec, Canada INTRODUCTION For the past several decades, the standard diagnostic and clinical research tool in endocrinology has been the hormone assay. The enormous surge in the development and use of molecular and cell biology technologies in the past two decades has advanced Read More
Genetics and Hormones in Testicular Descent*
Marko Kaleva and Jorma Toppari Departments of Physiology and Paediatrics, University of Turku, FIN-20520 Turku, Finland * This work was supported by the Turku University Central Hospital, the Academy of Finland and the European Commission (contracts BMH4-CT96-0314, QLK4-CT1999-01422, QLK4-CT2001-00269 and QLK4-CT2002-00603) Abstract Testicular descent is an essential part of normal male sexual development. Any anomaly Read More
GH deficiency in adults
Dimitrios S Papadogias1, Polyzois Makras1, Gregory A Kaltsas1,2, John P Monson2 Departments of Endocrinology, 1G. Gennimatas General Hospital, Athens Greece, 2St Bartholomew's Hospital, London EC1A 7BE, UK Abstract Until the last decade, the diagnosis of GH deficiency (GHD) in adults was only considered as a marker of hypothalamo-pituitary disease. GHD in adults is now recognized Read More
The-2548G/A polymorphism in the human leptin gene promoter region is associated with plasma free leptin levels; interaction with adiposity and gender in healthy subjects
Nikos Yiannakouris1, Labros Melistas1, Mary Yannakoulia1, Keisha Mungal2, Christos S. Mantzoros2 1Departments of Home Economics and Ecology and Nutrition-Dietetics, Harokopio University, 176 71 Athens, Greece, 2Division of Endocrinology and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA Abstract A common -2548G/A promoter variant of the human leptin Read More
Effect of Restoration of Euthyroidism on Peripheral Blood Cells and Erythropoietin in Women with Subclinical Hypothyroidism
Mirjam Christ-Crain1, Christian Meier1, Peter Huber2, Henryk Zulewski1, Jean-Jacques Staub1, Beat Müller1 1Division of Endocrinology, Diabetes, and Clinical Nutrition, Department of Internal Medicine, and 2Department of Central Laboratories, University Hospitals, CH-4031 Basel, Switzerland Supported by grants from the Swiss National Science Foundation (32.27866.89, 32.37792.93, and 32.37792.98) and unconditional research grants from Henning Berlin, Novartis, Roche Read More
The Influence of Serum Cortisol Levels on Growth Hormone Responsiveness to GH-Releasing Hormone Plus GH-Releasing Peptide-6 in Patients with Hypocortisolism
Sandra Pekic1, Mirjana Doknic1, Marina Djurovic1, Svetozar Damjanovic1, Milan Petakov1, Dragana Miljic1, Carlos Dieguez2, Felipe F Casanueva3, Vera Popovic1 1Institute of Endocrinology, University Clinical Center, Belgrade, Yugoslavia, 2Department of Physiology and 3Department of Medicine, Faculty of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain Abstract The aim of this study was to evaluate Read More