Michael S. Shawky1,2 1Department of Head and Neck and Endocrine Surgery, Faculty of Medicine, University of Alexandria, Egypt; 2Department of Surgery, University College Hospital, London, UK Abstract Continuous development of quick parathyroid hormone assays has resulted in a corresponding expansion of their applications in the practical landscape. In-theatre measurement of the parathyroid hormone has long Read More
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Calcium homeostasis in women with non-metastatic breast cancer with osteoporosis after a single dose of denosumab: a pilot study
Konstantinos Toulis1,2, Paschalia Iliadou1, Stylianos Mandanas1, Polyzo Kazila3, Efterpi Margaritidou1,Konstantinos Georgopoulos1, Kalliopi Pazaitou-Panayiotou1 1Department of Endocrinology, Theagenio Cancer Hospital, 2Department of Endocrinology, 424 General Military Hospital, 3Department of Clinical Chemistry, Theagenio Cancer Hospital; Thessaloniki, Greece Dear Sir, Along with achieving a reduction in the incidence of osteoporotic fractures, denosumab (a human monoclonal antibody against the receptor activator Read More
A novel truncating AIP mutation, p.W279*, in a familial isolated pituitary adenoma (FIPA) kindred
Güven Barış Cansu,1 Bengür Taşkıran,1 Giampaolo Trivellin,2 Fabio R. Faucz,2 Constantine A. Stratakis2 1Division of Endocrinology and Metabolism, Yunus Emre State Hospital, 26190, Eskişehir, Turkey; 2Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD, 20892, USA Abstract Familial isolated pituitary Read More
Low-risk papillary thyroid carcinoma patients who underwent near-total thyroidectomy without prophylactic central compartment lymph node dissection and were ablated with low-dose 50mCi RAI had excellent 10-year prognosis
Marina Michalaki, Panagiotis Bountouris, Nikolaos D Roupas, Anastasia Theodoropoulou, Niki Agalianou, Theodoros Alexandrides, Kostas Markou Endocrine Division, Internal Medicine Department, University of Patras, Medical School, Rion, Patras, Greece Abstract BACKGROUND: The current trend in the management of low risk differentiated thyroid carcinoma is to follow less aggressive strategies. Objective: To assess the long-term morbidity and Read More
Urinary steroid metabolites in a case of florid Ectopic Cushing’s syndrome and clinical correlations
Angelos Kyriacou,1 Karolina M. Stepien,2 Basil Issa1 1Department of Endocrinology & Diabetes, 2Department of Clinical Biochemistry, University Hospital of South Manchester (UHSM), Manchester, UK Abstract A 51-year old woman was admitted with multiple cerebral, pulmonary and intra-abdominal abscesses. The combination of apparent immunosuppression, obesity, diabetes mellitus, hypertension, hypokalaemia, osteoporotic fractures and bilateral shoulder avascular necrosis Read More
Hormones in pain modulation and their clinical implications for pain control: a critical review
Xueyin Chen, Jinyuan Zhang, Xiangrui Wang Department of Pain Management, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China Abstract Recently, more and more studies have found that pain generation, transmission and modulation are under hormonal regulation. Indeed, hormonal dysregulation is a common component of chronic pain syndromes. Studies have attempted to determine Read More
Postprandial dysmetabolism: Too early or too late?
Christos Pappas,1 Eleni A. Kandaraki,2 Sofia Tsirona,1 Dimitrios Kountouras,3 Georgia Kassi,2 Evanthia Diamanti-Kandarakis1 1Department of Endocrinology and Diabetes Center of Excellence, EUROCLINIC, Athens, Greece; 2Endocrine Unit 3rd Department of Medicine University of Athens Medical School, Athens, Greece; 3Department of Medicine Hepatology Unit, Hygeia Hospital, Athens, Greece Abstract Postprandial dysmetabolism is a postprandial state characterized by Read More
Adiponectin and end-stage renal disease
Anastasia Markaki, Emmanuel Psylinakis, Aspasia Spyridaki Department of Nutrition and Dietetics, Technological Educational Institute of Crete, Greece Abstract Adiponectin (ADPN) is an adipokine with significant anti-inflammatory, insulin-sensitizing and anti-atherogenic properties, which is generally associated with a beneficial cardiometabolic profile. Paradoxically, end-stage renal disease (ESRD) is characterized by markedly increased plasma ADPN levels and increased cardiovascular Read More
The human Ec peptide: the active core of a progression growth factor with species-specific mode of action
Efstathia Papageorgiou,* Anastassios Philippou,* Athanasios Armakolas,* Panagiotis F. Christopoulos, Andreas Dimakakos, Michael Koutsilieris Department of Experimental Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece *Equal contribution to this manuscript Abstract OBJECTIVE: Preferential IGF-1Ec expression has been firmly associated with skeletal muscle repair mechanisms, post-infarction remodeling of the myocardium, the pathophysiology of endometriosis Read More
A new TRβ mutation in resistance to thyroid hormone syndrome
Corina Neamţu,1 Claudiu Ţupea,1 Diana Păun,1 Anca Hoisescu,1 Adina Ghemigian,1 Samuel Refetoff,2 Chutintorn Sriphrapradang2 1National Institute of Endocrinology “C.I. Parhon”, Bucharest, Romania; 2University of Chicago Medicine, IL, USA Abstract Thyroid hormones (TH) exert their actions by binding nuclear receptors alpha (TRα1) and beta (TRß1 and TRß2). Resistance to thyroid hormone (RTH) is a clinical syndrome Read More