Alessandro Sindoni,1 Fausto Famà,2 Maria Gioffre-Florio,2 Sergio Baldari1 1Department of Biomedical and Dental Sciences and of Morphological and Functional Images, 2Department of Human Pathology, University Hospital of Messina, Messina, Italy Dear Sir, It was with great interest that we read the article titled “Neoadjuvant therapy for advanced pancreatic neuroendocrine tumors: an emerging treatment modality?” by Read More
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Young adult patient with headache, fever and blurred vision
Stavroula A. Paschou,1 Konstantinos Tzioras,1 Vasiliki Trianti,1 Stavroula Lyra,2 Vasileios-Arsenios Lioutas,3 Andreas Seretis,4 Andromachi Vryonidou1 1Department of Endocrinology and Diabetes, 2Department of Radiology, Hellenic Red Cross Hospital, Athens, Greece; 3Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; 4Department of Neurosurgery, “G. Gennimatas” General Hospital, Athens, Greece Abstract BACKGROUND AND Read More
Defining optimal vitamin D cut-off levels: Τhe role of parathyroid hormone concentrations
Spyridon N. Karras,1 William B.Grant,2 Declan P. Naughton,3 Kalliopi Kotsa1 1First Department of Internal Medicine, Division of Endocrinology and Metabolism, AHEPA Hospital, Thessaloniki, Greece; 2Sunlight, Nutrition, and Health Research Center, San Francisco, CA, USA; 3School of Life Sciences, Pharmacy and Chemistry, Kingston University, Penrhyn Road, Kingston upon Thames, KT1 2EE, UK Dear Editor, We read Read More
Preoperative markers in differentiated thyroid cancer
Alexandra Chrisoulidou Department of Endocrinology, Theagenio Cancer Hospital, Thessaloniki, Greece Dear Editor, I read with great interest the article by Yazici et al1 on TSH/Tg ratio in the prediction of thyroid cancer. The justification for thyroid surgery in patients with thyroid nodules has led to many interesting studies looking into predictive markers, albeit without as Read More
Muscular effects of vitamin D in young athletes and non-athletes and in the elderly
Nikolaos E. Koundourakis, Pavlina D. Avgoustinaki, Niki Malliaraki, Andrew N. Margioris Department of Clinical Chemistry, School of Medicine, University of Crete, Heraklion, Greece Abstract Muscles are major targets of vitamin D. Exposure of skeletal muscles to vitamin D induces the expression of multiple myogenic transcription factors enhancing muscle cell proliferation and differentiation. At the same Read More
Glycemic control in patients with insulinoma
Agata Matej,1 Hanna Bujwid,2 Jakub Wroński3 1Prof. W. Orlowski Hospital, Warsaw, Poland; 2Wolski Hospital, Warsaw, Poland; 3Department of Disaster Medicine, Warsaw Medical University, Warsaw, Poland Abstract Insulinoma is the most common neuroendocrine tumor of the pancreas. Surgical management of insulinomas is considered to be the only curative method. However, effective glycemic control preoperatively and in Read More
Thyroid hormones: a potential ally to LDL-cholesterol-lowering agents
Leonidas H. Duntas,1 Gabriela Brenta2 1Evgenidion Hospital, Unit of Endocrinology Diabetes and Metabolism, Thyroid Section, University of Athens, Greece; 2Dr. Cesar Milstein Hospital, Buenos Aires, Argentina Abstract L-thyroxine (LT4) treatment of hypothyroidism, particularly in patients with thyroid- stimulating hormone (TSH) >10mU/L, results in improved lipid profile, as LT4 stimulates low-density lipoprotein cholesterol (LDL-C) degradation and Read More
Leydig cell clustering and Reinke crystal distribution in relation to hormonal function in adult patients with testicular dysgenesis syndrome (TDS) including cryptorchidism
Rikke R. Soerensen,1,2 Trine H. Johannsen,1 Niels E. Skakkebaek,1 Ewa Rajpert-De Meyts1 1Department of Growth and Reproduction, and International Center for Research and Research Training on Endocrine Disrupting Effects on Male Reproduction & Child Health (EDMaRC), Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark, 2Department of Pathology, University Hospital Herlev, Herlev, Denmark Abstract OBJECTIVE: Testicular dysgenesis syndrome Read More
Parathyroid hormone response to severe vitamin D deficiency is associated with femoral neck bone mineral density: an observational study of 405 women with hip-fracture
Marco Di Monaco, Carlotta Castiglioni, Rosa Tappero Osteoporosis Research Center and Division of Physical Medicine and Rehabilitation, Presidio Sanitario San Camillo, Fondazione Opera San Camillo, Torino, Italy Abstract OBJECTIVE: Hip-fracture patients with vitamin D deficiency can have either secondary hyperparathyroidism or normal levels of parathyroid hormone (PTH). We hypothesized that bone mineral density (BMD) could Read More
Severe osteoporosis with multiple spontaneous vertebral fractures in a young male carrying triple polymorphisms in the vitamin D receptor, collagen type 1, and low-density lipoprotein receptor-related peptide 5 genes
Maria P. Yavropoulou,1 Panagoulia Kollia,2 Dimitris Chatzidimitriou,3 Stavroula Samara,2 Lemonia Skoura,3 John G. Yovos1 1Division of Endocrinology and Metabolism, 1st Department of Internal Medicine, AHEPA University hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece; 2Department of Genetics and Biotechnology, Faculty of Biology, School of Physical Sciences, University of Athens, Athens, Greece; 3Department of Microbiology, Medical School, Read More