Martin O. Savage1, Helen L. Storr1, Ashley B. Grossman1, Gerasimos E. Krassas2 1Department of Endocrinology, St Bartholomew's and The Royal London School of Medicine and Dentistry, London, UK, 2Department of Endocrinology and Metabolism, Panagia General Hospital, Thessaloniki, Greece Abstract Although paediatric Cushing's disease is rare, it is associated with severe morbidity in childhood and presents Read More
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The treacherous use of thyroxine preparations. Stability of thyroxine preparations
Demetrios A. Koutras Endocrine Unit, "Evgenidion Hospital", Athens University Medical School, Athens, Greece Endocrinologists not infrequently confront the problem of inconsistent blood values of thyroxine among patients receiving L-thyroxine preparations. The question is how universal this problem is. Before the use of L-thyroxine or thyroid gland preparations, hypothyroid patients were left untreated. It was therefore Read More
Relative Iron \”Overload\” in Offspring of Patients with Type 2 Diabetes Mellitus: A New Component in the Conundrum of Insulin Resistance Syndrome?
Agathoklis Psyrogiannis1, Venetsana Kyriazopoulou1, Argiris Symeonidis2, Michalis Leotsinidis3, Apostolos G. Vagenakis 1Department of Medicine, Division of Endocrinology and Diabetes, 2Division of Hematology, 3Department of Public Health, University of Patras Medical School, Patras, Greece Abstract There are a few reports suggesting that subtle disturbances of iron metabolism are frequently found in patients with type 2 diabetes Read More
The use of recombinant human thyrotropin (Thyrogen) in the diagnosis and treatment of thyroid cancer
Leonidas H. Duntas1, Nikolaos Tsakalakos2, Brigitte Grab-Duntas3, Maria Kalarritou1, Elli Papadodima4 1Endocrine Unit, Evgenidion Hospital, University of Athens Medical School, 2Iaso General Hospital, 3Institute of Isotopic Studies, 4Henry Dunant Hospital, Athens, Greece Abstract The introduction of human recombinant thyrotropin (rhTSH/Thyrogen) into the diagnosis of thyroid cancer has substantially ameliorated the patient's quality of life through Read More
Stature of early Europeans
Michael Hermanussen Privat Dozent Dr. med., Aschauhof, 243 40 Altenhof, Germany Abstract The ancestors of modern Europeans arrived in Europe at least 40,000 years before present. Pre-glacial maximum Upper Palaeolithic males (before 16,000 BC) were tall and slim (mean height 179 cm, estimated average body weight 67 kg), while the females were comparably small and Read More
Congenital lipoid adrenal hyperplasia caused by a frame-shift mutation in the steroidogenic acute regulatory protein gene
Anastasios Papadimitriou1,2, Ioanna Fountzoula2, Georgia Tzortzatou2, Himangshu S. Bose3 1Endocrine Clinic, 2First Department of Pediatrics, Penteli Children's Hospital, Athens 152 36, Greece, 3Department of Pediatrics, University of California, San Francisco, CA 94143-0978, USA Abstract We present a female patient who, at the age of 35 days, presented with adrenal insufficiency with salt loss. Clinical and Read More
Macroprolactinemia. Is treatment necessary?
Irene V. Lambrinoudaki1, Olga D. Daskalaki2, Stathis A. Thomopoulos2, Panayiotis Schinochoritis3, Argyris B. Argyropoulos2 12nd Department of Obstetrics and Gynecology, University of Athens, School of Medicine, "Aretaieion" Hospital, 2Department of Endocrinology, Diabetes and Metabolism"Agios Panteleimon" District General Hospital of Nikea, Piraeus, Greece, 3Biomedicine International Diagnostic Services Abstract A 26-year old symptom-free woman was admitted to Read More
The Hippocratic Spirit
George K. Daikos Amphiarion Foundation of Chemotherapeutic Studies, Athens Greece The Hippocratic medical school (the medical school of Kos) was not an isolated phenomenon but the evolution and consequence of previous ideas and practices derived from many older sources. Hippocratic medicine1-3 replaced the theurgical and hieratic medicine, succeeding to and evolving from the medicine of Read More
Growth Management of Children and Adolescents with Cushing\’s Disease
In this issue, Savage et al., summarize and discuss their data and those of the literature on the growth management of pediatric patients with Cushing's disease1. Endogenous Cushing's syndrome is rare in all ages and children and adolescents represent about 10 percent of the total2. The effect of hypercortisolism on growth is profound and proportional Read More
Macroprolactinemia: an unnoticeable factor
Hyperprolactinemia most commonly results from physiologic or pathologic conditions that cause hypersecretion of PRL by lactotroph cells. Physiologic causes include pregnancy and lactation while pathologic hyperprolactinemia may result from a lactotroph adenoma or from several readily identifiable causes that may interfere with normal dopamine inhibition of PRL secretion. However, in some patients whose serum PRL Read More