Iraklis Perysinakis,1 Chrysanthi Aggeli,1 Gregory Kaltsas,2 George N. Zografos1 1Third Department of Surgery, General Hospital “G. Gennimatas”; 2Department of Pathophysiology, National University of Athens; Athens, Greece Abstract OBJECTIVE: Complete surgical resection is the only potentially curative treatment of localized pancreatic neuroendocrine tumors. Unfortunately, a significant proportion of these patients present with unresectable locally advanced tumors Read More
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The Sertoli cell: Novel clinical potentiality
Paschalia K. Iliadou, Christos Tsametis, Athina Kaprara, Ioannis Papadimas, Dimitrios G. Goulis Unit of Reproductive Endocrinology, First Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Greece Abstract The Sertoli cell is important for endocrine and paracrine control of spermatogenesis. Functions attributed to Sertoli cells are: (1) supportive and trophic functions for the Read More
The impact of adipose tissue-derived factors on the hypothalamic-pituitary-gonadal (HPG) axis
Christos Tsatsanis, Eirini Dermitzaki, Pavlina Avgoustinaki, Niki Malliaraki, Vasilis Mytaras, Andrew N. Margioris Department of Clinical Chemistry, School of Medicine, University of Crete, Heraklion, Crete, Greece Abstract Adipose tissue produces factors, including adipokines, cytokines and chemokines which, when released, systemically exert endocrine effects on multiple tissues thereby affecting their physiology. Adipokines also affect the hypothalamic-pituitary-gonadal Read More
Hypogonadism in young men treated for cancer
Aleksander Giwercman1, Yvonne Lundberg Giwercman2 1Molecular Reproduction, 2Molecular Genetic Reproduction, Department of Translational Medicine, Lund University, Malmö, Sweden Abstract An ever-increasing proportion of young males treated for cancer are cured. Therefore, one of the major challenges of modern Clinical Oncology is to ensure good quality of life. Cancer disease per se as well as cancer Read More
Editorial
Aleksander Giwercman, Dimitrios G. Goulis, Ilpo Huhtaniemi, Christos Tsatsanis This issue of HORMONES is dedicated to the Symposium “Endocrine Aspects in Andrology” that took place in Heraklion, Crete, Greece, on 13-15 March, 2015. An educational activity organized by the Faculty of Medicine, University of Crete, it was held under the auspices of the European Read More
Genetic screening of non-classic CAH females with hyperandrogenemia identifies a novel CYP11B1 gene mutation
Christos Shammas,1 Stefania Byrou,1 Marie M. Phelan,2 Meropi Toumba,3 Charilaos Stylianou,4 Nicos Skordis,1 Vassos Neocleous,1 Leonidas A. Phylactou1 1Department of Molecular Genetics, Function & Therapy, The Cyprus Institute of Neurology & Genetics, Nicosia, Cyprus; 2NMR Centre for Structural Biology, Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom; 3Division of Pediatrics, Iasis Hospital, Pafos, Read More
The gonadotroph origin of null cell adenomas
George Kontogeorgos, Eleni Thodou Department of Pathology G. Gennimatas Athens General Hospital, Athens, Greece Abstract OBJECTIVE: The term “null cell” adenoma was first proposed in 1980 to designate pituitary adenomas lacking clinical, biochemical and morphological markers to disclose their cell origin. DESIGN: The aim of this study was to investigate the presence of α- and Read More
Adrenal malignant melanoma masquerading as a pheochromocytoma in a patient with a history of a multifocal papillary and medullary thyroid carcinoma
Maria E. Barmpari,1 Christos Savvidis,1 Anastasia D. Dede,1 Haridimos Markogiannakis,2 Christina Dikoglou,3 Paraskevi Xekouki,4 Constantine A. Stratakis,4 Andreas Manouras,2 Sofia Malaktari-Skarantavou1 1Department of Endocrinology and Metabolism, Hippokration Hospital, Athens, 2Department of Endocrine Surgery, First Department of Propaedeutic Surgery, Hippokration Hospital, Athens Medical School, University of Athens, 3Department of Pathology, Hippokration Hospital, Athens, Greece; 4Section of Read More
A novel CYP11B1 mutation in a Turkish patient with 11β-hydroxylase deficiency: An association with the severe hypokalemia leading to rhabdomyolysis
Banu Sarer Yurekli, Nilufer Ozdemir Kutbay, Huseyin Onay, Ilgin Yildirim Simsir, Gokcen Unal Kocabas, Mehmet Erdogan, Sevki Cetinkalp, Gokhan Ozgen, Fusun Saygili Ege University Faculty of Medicine, Endocrinology Department, Bornova, Izmir, Turkey Dear Sir, Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder caused by the loss of one of five steroidogenic enzymes affecting cortisol Read More
A complicated case of primary hypophysitis with bilateral intracavernous carotid artery occlusion
Pinelopi Katsiveli,¹ Maria Sfakiotaki,¹ Nikolaos Voulgaris,¹ Labrini Papanastasiou,¹ Theodora Kounadi,¹ Konstantinos Lymperopoulos,² George Piaditis¹ 1Department of Endocrinology and Diabetes Center, 2Department of Interventional Radiology, General Hospital of Athens “G. Gennimatas”, Athens, Greece Abstract Primary hypophysitis (PH) is a rare clinical entity characterized by inflammatory infiltration of the pituitary gland with various degrees of pituitary dysfunction. Read More