Malik Asif Humayun,1 Ruth Poole2 1Royal Bournemouth Hospital, Bournemouth, 2Poole Hospital, NHS Foundation Trust, Poole; UK Dear Sir, Monoclonal antibodies have revolutionized the management of complex and challenging human diseases such as malignancies as well as haematological, rheumatologic and other autoimmune conditions over the last three decades.1 At the same time, they are associated with Read More
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A case of dyskeratosis congenita associated with hypothyroidism and hypogonadism
Nilufer Ozdemir Kutbay, Banu Sarer Yurekli, Zehra Erdemir, Emin Karaca, Idil Unal, Banu Yaman, Ferda Ozkinay, Fusun Saygili Ege University Faculty of Medicine, Endocrinology Department, Izmir, Turkey Dear Sir, Dyskeratosis congenita is a very rare multisystemic disorder and it can be accompanied by different endocrinological pathologies. We would like to draw attention to this rare Read More
More news from IMPROVE-IT (IMProved Reduction of Outcomes: Vytorin Efficacy International Trial)
Niki Katsiki,1 Vasilios G. Athyros,1 Dimitris P. Mikhailidis2 1Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece; 2Department of Clinical Biochemistry (Vascular Prevention Clinics), Royal Free Hospital Campus, University College Medical School, University College London, London, UK The IMProved Reduction of Outcomes: Vytorin Efficacy International Trial (IMPROVE-IT) reported Read More
Expert consensus on the rational clinical use of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors
Apostolos Achimastos,1 Theodoros Alexandrides,2 Dimitrios Alexopoulos,3 Vasilios Athyros,4 Alexandra Bargiota,5 Eleni Bilianou,6 Christina Chrysochoou,7 Evridiki Drogari,8 Moses Elisaf*,9 Emanouel Ganotakis,10 Ioannis Goudevenos,11 Ioannis Ioannidis,12 Genovefa Kolovou,13 Vasilios Kotsis,14 Ioannis Lekakis,15 Evangelos Liberopoulos,16 Andreas Melidonis,17 Vasilios Nikolaou,18 George Ntaios,19 Nikolaos Papanas,20 Stavros Pappas,21 Christos Pitsavos,22 Loukianos Rallidis,23 Dimitrios Richter,24 Ioannis Skoumas,25 Nicolaos Tentolouris,26 Dimitrios Tousoulis,27 Alexandros Read More
Recent advances in the molecular mechanisms causing primary generalized glucocorticoid resistance
Nicolas C. Nicolaides,1,2 Agaristi Lamprokostopoulou,2 Amalia Sertedaki,1 Evangelia Charmandari1,2 1Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, University of Athens Medical School, ‘Aghia Sophia’ Children’s Hospital; 2Division of Endocrinology and Metabolism, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens; Athens, Greece Abstract Primary Generalized Glucocorticoid Read More
Corticotropin-releasing factor (CRF) system localization in human fetal heart
Efterpi Chouridou,1 Maria Lambropoulou,2 Maria Koureta,1 Christina Zarouchlioti,1 Ioanna Balgouranidou,1 Evangelia Nena,3 Nikolaos Papadopoulos,2 Ekaterini Chatzaki1 1Laboratory of Pharmacology, 2Laboratory of Histology-Embryology, 3Laboratory of Hygiene and Environmental Protection, Faculty of Medicine, Democritus University of Thrace, Dragana, Alexandroupolis, Greece Abstract OBJECTIVE: The corticotropin-releasing factor (CRF) family consists of the neuropeptides CRF, Ucn I, II and III Read More
Prevalence and determinants of type 2 diabetes mellitus in a Greek adult population
Sofia Tsirona, Fotis Katsaros, Alexandra Bargiota, Stergios A. Polyzos, George Arapoglou, George N. Koukoulis Department of Endocrinology and Metabolic Diseases, University Hospital, School of Medicine, University of Thessaly, Biopolis, Larissa, Greece Abstract The prevalence of diabetes mellitus (DM) is increasing worldwide reaching epidemic proportions. The aim of the present study was to estimate the prevalence Read More
The relationship between retinol-binding protein 4 and apolipoprotein B-containing lipoproteins is attenuated in patients with very high serum triglycerides: A pilot study
Georgios A. Christou,1 Constantinos C. Tellis,2 Moses S. Elisaf,3 Alexandros D. Tselepis,2 Dimitrios N. Kiortsis1 1Laboratory of Physiology, Medical School, 2Laboratory of Biochemistry, Department of Chemistry, 3Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece Abstract OBJECTIVE: The investigation of the association between retinol-binding protein 4 (RBP4)and lipoproteins in subjects with hypertriglyceridemia. DESIGN: Read More
Depressive symptoms in obese patients study
Bulent Canbaz Ankara Numune Hospital, Department of Endocrinology, Ankara, Turkey To the Editor, The study by Huang et al1 sheds valuable light on how obesity may cause depression. However, depressed people are known to be at higher risk for developing obesity in the first place.2 It is therefore important to know whether any of the Read More
Laparoscopic surgery for pancreatic insulinomas: an update
Chrysanthi Aggeli,1 Alexander M. Nixon,1Ioannis Karoumpalis,2 Gregory Kaltsas,3 George N. Zografos1 1Third Department of Surgery, 2Department of Gastroenterology, Athens General Hospital “Georgios Gennimatas”, Athens, 3Department of Pathophysiology, Laiko Hospital, Athens Greece Abstract Insulinomas are the most common functioning neuroendocrine tumors of the pancreas, occurring in almost 1-4 per 1 million persons each year. In contrast Read More