Thalia Bei2*, Constantinos Tilkeridis1*, Stavros Garantziotis3, Sosipatros A. Boikos2, Konstantinos Kazakos1, Constantinos Simopoulos1, Constantine A. Stratakis2 1“Democritus” University of Thrace, Alexandroupolis, Greece, 2Section on Genetics and Endocrinology, Program on Developmental Endocrinology & Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA, 3Center for Recruitment of Military Personnel for Read More
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Hypothalamic-pituitary-adrenal axis in patients with ankylosing spondylitis
Mehmet Kirnap1, Hulusi Atmaca2, Fatih Tanriverdi2, Osman Ozsoy1, Kursad Unluhizarci2, Fahrettin Kelestimur2 1Department of Physical Medicine and Rehabilitation, 2Department of Endocrinology and Metabolism, Erciyes University Medical School, Kayseri, Turkey Abstract OBJECTIVE: To investigate the hypothalamic-pituitary-adrenal (HPA) axis via the insulin-tolerance test (ITT), standard-dose (250 μg) ACTH test (SDT) and low-dose (1 μg) ACTH test (LDT) Read More
EFFECT OF THYROID STATUS ON THE SKELETON IN POST-MENOPAUSAL WOMEN: THE OPUS STUDY
Williams G.R. 1, Murphy E.1, Gl?er C.C.2, Reid M.D.3, Felsenberg D.4, Roux C.5, Eastell R.6 1Molecular Endocrinology Group, Imperial College London, London, UK, 2Universitätsklinikum Schleswig-Holstein, Kiel, Germany, 3Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, UK, 4Free University, Berlin, Germany, 5Rene Descartes University, Paris, France, 6Academic Unit of Bone Metabolism, University of Sheffield, Sheffield, Read More
VANDETANIB (300 MG) IN METASTATIC HEREDITARY MEDULLARY THYROID CANCER: A PHASE II OPEN-LABEL STUDY
Wells A.S.1, Gosnell J.2, Gagel F.R.3, Moley J.4, Pfister D.5,Sosa J.A.6, Skinner M.A.7, Krebs A.D.8, Vasselli J.9, Schlumberger M.10 1Washington University School of Medicine, St Louis, MO, USA, 2University of California at San Francisco, San Francisco, CA, USA, 3UTMD Anderson Cancer Center, Houston, TX, USA, 4Washington University School of Medicine, St Louis, MO, USA, 5Memorial Read More
A LOW MOLECULAR WEIGHT ANTAGONIST PREVENTS TSH- AND ANTIBODY-INDUCED ACTIVATION OF THE HUMAN THYROTROPIN RECEPTOR
Krause G.1, Neumann S.2, Kleinau G.1, Costanzi S.2, Moore S.2, Jiang J.3, Raaka B. M.2, Thomas J. C.3, Gershengorn C. M.2 1Leibniz-Institut f?r Molekulare Pharmakologie, Berlin, Germany, 2National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA, 3NIH Chemical Genomics Center, National Human Genome Research Institute, Bethesda, MD, USA Abstract The thyroid-stimulating Read More
THE MECHANISM OF TRH-INDUCED TRANSACTIVATION OF TSH BETA GENE
Nakamura H.1, Ohba K.1, Nagayama K.1, Matsushita A.1, Kashiwabara Y.1, Iwaki H.1, Matsunaga H.1, Misawa H.1, Ishizuka K.1, Sasaki S.1 1 Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan Abstract The regulation of thyrotropin (TSH) by thyroid hormone (T3) negatively and by TSH-releasing hormone (TRH) positively is crucial to Read More
IDENTIFICATION OF NEW GENES INVOLVED IN THYROID DEVELOPMENT AND DIFFERENTIATION
Amendola E.1, Sanges R.3, De Luca P.2, Galvan A.5, Terracciano D.4, macchia V.4, Dragani T.5, De Felice m.4, Di Lauro R.1 1Stazione Zoologica A. Dohrn, 2Biogem s.c.a r.l, Ariano Irpino, 3TIGEM, Napoli, 4Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita Federico II, Napoli, 5Istituto Nazionale dei Tumori, Milan Abstract We have generated a polygenic Read More
Craniopharyngiomas. Historical aspects of their management
Eleanor Roderick, Niki Karavitaki, John AH Wass Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, United Kingdom Abstract The history of the management of craniopharyngiomas offers a comprehensive review of the exciting progress in neurosurgery, neuroimaging, neuroendocrinology and radiation oncology during the last century. In this historical note, we present Read More
A prismatic case: A 31-year old man who did not miss his pituitary
Stefanie Petzold1, Alexandra Keller1, Eberhardt Keller1, Christof Meigen1, Wolfgang Hirsch2, Jürgen Kratzsch3, Wieland Kiess1, Roland Pfäffle1 1Hospital for Children and Adolescents, 2Department of Diagnostic Radiology, Paediatric Radiology, 3Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Germany Abstract Combined pituitary hormone deficiency (CPHD) is a rare disorder resulting from impaired production of Read More
Ectopic Cushing?s syndrome due to CRH secreting liver metastasis in a patient with medullary thyroid carcinoma
Alexandra Chrisoulidou1, Kalliopi Pazaitou-Panayiotou1, Eleni Georgiou1, Maria Boudina1, George Kontogeorgos2, Ioannis Iakovou1, Ioannis Efstratiou3, Frideriki Patakiouta4, Iraklis Vainas1 1Unit of Endocrinology & Endocrine Oncology, “Theagenio” Cancer Hospital, Thessaloniki, 2Unit of Pathology, “G. Gennimatas” Athens General Hospital, 3Unit of Pathology, “Papageorgiou” Hospital, 4Unit of Pathology, “Theagenio” Cancer Hospital, Thessaloniki, Greece Abstract Ectopic production of CRH by Read More