Eleanor Roderick, Niki Karavitaki, John AH Wass Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, United Kingdom Abstract The history of the management of craniopharyngiomas offers a comprehensive review of the exciting progress in neurosurgery, neuroimaging, neuroendocrinology and radiation oncology during the last century. In this historical note, we present Read More
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IDENTIFICATION OF NEW GENES INVOLVED IN THYROID DEVELOPMENT AND DIFFERENTIATION
Amendola E.1, Sanges R.3, De Luca P.2, Galvan A.5, Terracciano D.4, macchia V.4, Dragani T.5, De Felice m.4, Di Lauro R.1 1Stazione Zoologica A. Dohrn, 2Biogem s.c.a r.l, Ariano Irpino, 3TIGEM, Napoli, 4Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita Federico II, Napoli, 5Istituto Nazionale dei Tumori, Milan Abstract We have generated a polygenic Read More
RADIOIODINE IS AN EFFECTIVE AND SAFE ADJUVANT TREATMENT IN CHILDREN WITH DIFFERENTIATED THYROID CANCER (DTC
Handkiewicz-Junak D.1, Kropinska A.1, Krajewska J.1, Roskosz J.1, Puch Z.1, Olczyk T.1, Jarzab B.1 1Department of Nuclear Medicine and Endocrine Oncology, MSC Memorial Cancer and Institute of Oncology, Gliwice Branch, Gliwice, Poland Abstract Background: We proved recently that in children adjuvant radioiodine is effective in decreasing risk of locoregional recurrence even after radical surgery. The Read More
CLINICAL UTILITY OF A SECOND RECOMBINANT HUMAN TSH STIMULATION IN DIFFERENTIATED THYROID CANCER PATIENT
Torlontano M.1, Crocetti U.1, Durante C.4, Attard M.5, Maniglia A.5, Tumino S.6, Bruno R.7, Bonfitto N.2, Dicembrino F.3, Varraso A.3, Meringolo D.8, Filetti S.4, Trischitta V.1,4,9 1Units of Endocrinology, 2Thoracic Surgery, 3Nuclear Medicine, Scientific Institute Casa Sollievo della Sofferenza, S. Giovanni Rotondo, Italy, 4Department of Clinical Sciences, Sapienza University, Rome, Italy, 5Unit of Endocrinology, Cervello Read More
TELOMERASE-DRIVEN EXPRESSION OF THE SODIUM IODIDE SYMPORTER (NIS) FOR IN VIVO RADIOIODIDE IMAGING AND TREATMENT OF CANCER: A NEW BROAD-SPECTRUM NIS-MEDIATED ANTITUMOUR APPROACH
Riesco-Eizaguirre G.1, De La Vieja A.2, Rodriguez-Garcia I.2, Martin-Duque P.3, Vassaux G.4, Santisteban P.2 1Hospital Universitario La Paz, Madrid, Spain, 2Instituto de Investigaciones Biomedicas “Alberto Sols”, CSIC-UAM, Madrid, Spain, 3Departamento de Biotecnologia, Universidad Francisco de Vitoria, Madrid, Spain, 4Centre for Molecular Oncology, Institute of Cancer, Queen Mary’s School of Medicine and Dentistry, London, UK Abstract Read More
A LINK BETWEEN X CHROMOSOME INACTIVATION PATTERN AND SUBCLINICAL AUTOIMMUNE THYROID DISEASE EVIDENCE FROM A TWIN STUDY
Hansen P.S.1, Brix T.H.2, Knudsen G.P.S.3, Kringen M.K.3, Kyvik K O.1, Sorensen T. H.I.A.4, Orstavik K.H.5, Heged?s L.2 1The Danish Twin Registry, University of Southern Denmark, Odense, Denmark, 2Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark, 3Faculty Division Rikshospitalet, University of Oslo, Oslo, Norway, 4Danish Epidemiology Science Centre, Institute of Preventive Medicine, Copenhagen Read More
EFFECT OF THYROID STATUS ON THE SKELETON IN POST-MENOPAUSAL WOMEN: THE OPUS STUDY
Williams G.R. 1, Murphy E.1, Gl?er C.C.2, Reid M.D.3, Felsenberg D.4, Roux C.5, Eastell R.6 1Molecular Endocrinology Group, Imperial College London, London, UK, 2Universitätsklinikum Schleswig-Holstein, Kiel, Germany, 3Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, UK, 4Free University, Berlin, Germany, 5Rene Descartes University, Paris, France, 6Academic Unit of Bone Metabolism, University of Sheffield, Sheffield, Read More
VANDETANIB (300 MG) IN METASTATIC HEREDITARY MEDULLARY THYROID CANCER: A PHASE II OPEN-LABEL STUDY
Wells A.S.1, Gosnell J.2, Gagel F.R.3, Moley J.4, Pfister D.5,Sosa J.A.6, Skinner M.A.7, Krebs A.D.8, Vasselli J.9, Schlumberger M.10 1Washington University School of Medicine, St Louis, MO, USA, 2University of California at San Francisco, San Francisco, CA, USA, 3UTMD Anderson Cancer Center, Houston, TX, USA, 4Washington University School of Medicine, St Louis, MO, USA, 5Memorial Read More
A LOW MOLECULAR WEIGHT ANTAGONIST PREVENTS TSH- AND ANTIBODY-INDUCED ACTIVATION OF THE HUMAN THYROTROPIN RECEPTOR
Krause G.1, Neumann S.2, Kleinau G.1, Costanzi S.2, Moore S.2, Jiang J.3, Raaka B. M.2, Thomas J. C.3, Gershengorn C. M.2 1Leibniz-Institut f?r Molekulare Pharmakologie, Berlin, Germany, 2National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA, 3NIH Chemical Genomics Center, National Human Genome Research Institute, Bethesda, MD, USA Abstract The thyroid-stimulating Read More
THE MECHANISM OF TRH-INDUCED TRANSACTIVATION OF TSH BETA GENE
Nakamura H.1, Ohba K.1, Nagayama K.1, Matsushita A.1, Kashiwabara Y.1, Iwaki H.1, Matsunaga H.1, Misawa H.1, Ishizuka K.1, Sasaki S.1 1 Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan Abstract The regulation of thyrotropin (TSH) by thyroid hormone (T3) negatively and by TSH-releasing hormone (TRH) positively is crucial to Read More