FATE MAPPING REVEAL THAT MIDLINE THYROID PROGENITORS ARISE FROM SONIC HEDGEHOG (SHH) NEGATIVE FOREGUT ENDODERM BUT SHH POSITIVE CELLS ENTER THE THYROID VIA THE PHARYNGEAL POUCHES

Nilsson M., Westerlund J., Fagman H. Department of Medical Chemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden Abstract The thyroid develops from distinct regions in the foregut endoderm, the midline and lateral primordia. To date no cell-autonomous factor responsible for the early specification of thyroid progenitor cells has been uncovered. Read More

PATHOGENIC CONSTITUTIVE ACTIVATION OF THE THYROTROPIN RECEPTOR CAUSED BY A NEWLY IDENTIFIED SINGLE SUBSTITUTION IN TRANSMEMBRANE HELIX 6

Kleinau G.1, Winkler F.1,2, Krause G.1, Gr?ters A.2, Biebermann H.2 1Leibniz-Institut fór Molekular Pharmakologie, Berlin, Germany, 2Institute for Experimental Pediatric Endocrinology, Charite Universitätsmedizin, Berlin, Germany Abstract Objectives: Familial non-autoimmune hyperthyroidism is a rare condition in which constitutively activating mutations in the TSH receptor (TSHR) gene are one molecular cause of the disease. Identified naturally occurring Read More

HIGH PREVALENCE OF TSHR/GS-MUTATION-NEGATIVE CLONAL TOXIC THYROID NODULES IN A TURKISH COHORT

Krohn K.1, 2, Sancak S.3, Jaeschke H.1, Sen Leyla S.4, G?ll?oglu M.B.4, Tanay Eren F.5, Sever Z.5, Akalin N.S.3, Paschke R.1, Eszlinger M.1 1III. Medical Department, University of Leipzig, Leipzig, Germany, 2IZKF Leipzig, University of Leipzig, Leipzig, Germany, 3Section of Endocrinology and Metabolism of Marmara University Medical School, Istanbul, Turkey, 4General Surgery Department of Marmara Read More

N6-ISOPENTENYLADENOSINE INDUCES APOPTOSIS IN THYROID CELL

Vitale M.1, Di Matola T.2, Laezza Ch.3, Moretti M.I.1, Fenzi G.1, Rossi G.2, Bifulco M.4 1Department of Endocrinologia e Oncologia Molecolare e Clinica, University of Naples Federico II, Naples, Italy, 2Department of Biologia e Patologia Cellulare e Molecolare, University of Naples Federico II, Naples, Italy, 3Institute of Endocrinologia e Oncologia, CNR, Naples, Italy, 4Department of Read More

COMPARISON OF EXPRESSED HUMAN AND MOUSE SODIUM IODIDE SYMPORTERS

Dayem M.1, Basquin C.1, Navarro V.1, Carrier P.1, Marsault R.1, Huc S.2, Darrouzet E.2, Lindenthal S.1, Pourcher Th.1 1TIRO, CEA DSV-iBEB-SBTN, CAL, University of Nice Sophia Antipolis, Nice, France, 2TIRO, CEA center of Valrho, DSV-iBEB-SBTN, Bagnols-sur-Ceze, France Abstract The active transport of iodide from the bloodstream into thyroid follicular cells is mediated by the Na+/I- Read More

FOLLICULAR ORGANIZATION OF CULTURED THYROCYTES AFFECTS MARKER GENE EXPRESSION AND CALCIUM SIGNALLING DYNAMICS

Lorenz S.1,2, Ziesche S.1, Leinung S.3, Aust G.3, Krohn K.1,2 1University of Leipzig, Medical Faculty, 3rd Medical Dept., 2Universtity of Leipzig, Medical Faculty, Interdisciplinary Center for Clinical Research, 3University of Leipzig, Medical Faculty, Clinic for Visceral, Thoracic, Vascular and Transplant Surgery Abstract We performed preparation and cell culture of human thyrocytes from biopsies of cold Read More

The adrenal glands: a brief historical perspective

Basil Leoutsakos1, Agnes Leoutsakos2 1Department of Surgery, Athens University Medical School, 2World Health Organization, Geneva, Switzerland  There have been numerous references to the existence of the adrenal glands ever since ancient times, with an increasing amount of knowledge being accumulated and recorded from the 16th century on.1 Although it would evidently not be possible to Read More

Primary tuberculosis of the thyroid gland

Ines Zendah, Hafaoua Daghfous, Sonia Ben Mrad, Fatma Tritar Abderrahmene Mami Hospital of Pneumology, C Pneumology Department, Tunis, Tunisia Abstract Thyroid tuberculosis is a rare disease even in countries in which tuberculosis (TB) constitutes an endemic disorder. The diagnosis is often difficult as the clinical presentation has no distinct characteristics. We report a 47-year-old woman Read More

Alterations of coagulation in metformin intoxication

Baris Akinci1, Serkan Yener1, Goksel Bengi2, Sena Yesil1 1Division of Endocrinology and Metabolism, 2Department of Internal Medicine, Dokuz Eylul University Medical School, Izmir, Turkey Abstract It is widely known that metformin reduces the levels of circulating pro-coagulant factors and improve fibrinolytic activity in type 2 diabetes when used in therapeutic doses. Potential alterations of coagulation Read More

Isolated adrenocorticotropin deficiency and flexion contractures syndrome

Vassiliki Syriou, Anestis Moisidis, Nikolaos Tamouridis, Krystallenia I. Alexandraki, Margarita Anapliotou Department of Pathophysiology, Division of Endocrinology, Athens University Medical School, Laiko Hospital, Athens, Greece Abstract We present a 73-year-old man with isolated adrenocorticotropic hormone deficiency and ?flexion contractures? syndrome along with a review of the relevant literature. The patient initially presented anorexia, vomiting, arthralgias, Read More