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Romei C., Botici V., Cosci B., Renzini G., Molinaro E., Agate L., Pinchera A., Elisei R. Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy Abstract Multiple Endocrine Neoplasia type 2 (MEN 2) is characterized by the presence of medullary thyroid cancer (MTC) and other benign pathologies. RET mutations are responsible of this disease Read More

Robinson B.1, Paz-Ares L.2, Krebs A.3, Vasselli J.3, Haddad R.4 1Kolling Institute of Medical Research, University of Sydney, Australia, 2Doce de Octubre University Hospital, Madrid, Spain, 3AstraZeneca, Wilmington, DE, USA, 4Dana-Farber Cancer Institute, Boston, MA, USA Abstract Objectives: Vandetanib (ZACTIMA™) is a once-daily oral agent that selectively targets RET, VEGFR and EGFR signalling pathways. Vandetanib Read More

Lee S., Ahn J., Chung Y.J. Internal medicine, Chung-Ang University Hospital, Seoul, Korea Abstract Down-regulation of p27Kip1, which is well-known cell cycle inhibitor, is associated with advanced stage of cancer and poor patient survival. However, recent studies show that cytoplasmic localization of p27Kip1 would be more meaningful rather than expression levels in terms of cancer Read More

Nilsson M., Westerlund J., Fagman H. Department of Medical Chemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden Abstract The thyroid develops from distinct regions in the foregut endoderm, the midline and lateral primordia. To date no cell-autonomous factor responsible for the early specification of thyroid progenitor cells has been uncovered. Read More

Kleinau G.1, Winkler F.1,2, Krause G.1, Gr?ters A.2, Biebermann H.2 1Leibniz-Institut fór Molekular Pharmakologie, Berlin, Germany, 2Institute for Experimental Pediatric Endocrinology, Charite Universitätsmedizin, Berlin, Germany Abstract Objectives: Familial non-autoimmune hyperthyroidism is a rare condition in which constitutively activating mutations in the TSH receptor (TSHR) gene are one molecular cause of the disease. Identified naturally occurring Read More

Krohn K.1, 2, Sancak S.3, Jaeschke H.1, Sen Leyla S.4, G?ll?oglu M.B.4, Tanay Eren F.5, Sever Z.5, Akalin N.S.3, Paschke R.1, Eszlinger M.1 1III. Medical Department, University of Leipzig, Leipzig, Germany, 2IZKF Leipzig, University of Leipzig, Leipzig, Germany, 3Section of Endocrinology and Metabolism of Marmara University Medical School, Istanbul, Turkey, 4General Surgery Department of Marmara Read More

Vitale M.1, Di Matola T.2, Laezza Ch.3, Moretti M.I.1, Fenzi G.1, Rossi G.2, Bifulco M.4 1Department of Endocrinologia e Oncologia Molecolare e Clinica, University of Naples Federico II, Naples, Italy, 2Department of Biologia e Patologia Cellulare e Molecolare, University of Naples Federico II, Naples, Italy, 3Institute of Endocrinologia e Oncologia, CNR, Naples, Italy, 4Department of Read More

Dayem M.1, Basquin C.1, Navarro V.1, Carrier P.1, Marsault R.1, Huc S.2, Darrouzet E.2, Lindenthal S.1, Pourcher Th.1 1TIRO, CEA DSV-iBEB-SBTN, CAL, University of Nice Sophia Antipolis, Nice, France, 2TIRO, CEA center of Valrho, DSV-iBEB-SBTN, Bagnols-sur-Ceze, France Abstract The active transport of iodide from the bloodstream into thyroid follicular cells is mediated by the Na+/I- Read More

Lorenz S.1,2, Ziesche S.1, Leinung S.3, Aust G.3, Krohn K.1,2 1University of Leipzig, Medical Faculty, 3rd Medical Dept., 2Universtity of Leipzig, Medical Faculty, Interdisciplinary Center for Clinical Research, 3University of Leipzig, Medical Faculty, Clinic for Visceral, Thoracic, Vascular and Transplant Surgery Abstract We performed preparation and cell culture of human thyrocytes from biopsies of cold Read More

Basil Leoutsakos1, Agnes Leoutsakos2 1Department of Surgery, Athens University Medical School, 2World Health Organization, Geneva, Switzerland  There have been numerous references to the existence of the adrenal glands ever since ancient times, with an increasing amount of knowledge being accumulated and recorded from the 16th century on.1 Although it would evidently not be possible to Read More