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Szpak-Ulczok S.1, Jarzab M.2, Oczko-Wojciechowska M.1, Kowalska M.1, Kowal M.1, Pfeifer A.1, Czarniecka A.3, Roskosz J.1, Handkiewicz-Junak D.1, Jarzab B.1 1Department of Nuclear Medicine and Endocrine Oncology, 2Clinical Oncology Clinic, 3Clinic of Oncological and Reconstructive Surgery, MSC Memorial Cancer Center and Institute of Oncology, Gliwice Branch Abstract Distant metastasis of papillary thyroid cancer occur in Read More

Castagna M. G., Cipri C., Tala H., Fioravanti C., Pasqui L., Sestini F., Brilli L. Belardini V., Ghezzi M., Pacini F. Department of Internal Medicine, Endocrinology, Metabolism and Biochemistry, Section of Endocrinology and Metabolism, University of Siena, Italy Abstract Recently, two different ultrasensitive serum Tg assays with low functional sensitivity (FS) (0.11 ng/ml Tg Access Read More

Rocha A. S.1, Blancquaert S.2, Populo H.3, Faustino A.4, Soares P.5, Roger P.6 1IRIBHM Brussels, Belgium, IPATIMUP, Porto, Portugal, 2IRIBHM, Brussels, Belgium, 3IPATIMUP Porto, Portugal, 4IPATIMUP Porto, Portugal, 5IPATIMUP Porto, Portugal, 6IRIBHM, Brussels, Belgium Abstract mTOR pathway regulates proliferation in several carcinoma models. Rapamycin is a specific inhibitor of Raptor-mTOR complex Predictors of tumour sensitivity Read More

Mannavola D.1, Vannucchi G.1, Covelli D.1, Coco P.2, Bertulli R.2, Casali P.2, Beck-Peccoz P.1, Fugazzola L.1 1Department of Medical Sciences, Endocrine Unit, University of Milan, IRCCS Fondazione Policlinico, MIlan, Italy, 2Department of Oncology, Istituto Nazionale dei Tumori, Milan, Italy Abstract Sunitinib is a multitarget inhibitor of tyrosine-kinases used in different human cancers with a high Read More

Blancquaert S.1, Wang L.2, Paternot S.1, Harris Th.2, Roger P.P.1 1IRIBHM, ULB, Campus Erasme, Brussels, Belgium, 2University of Virginia, Department of Pharmacology, USA Abstract In epithelial thyroid cells, phosphorylation of p70 S6K1 is the earliest convergence point between the distinct (co)mitogenic pathways. Whereas the general consensus is that p70 S6K1 phosphorylation is induced by the Read More

Frezzetti D.1, Guerra C.2, Barbacid M.2, Di Lauro R.3, De Vita G.4 1Biogem s.c.a r.l. Ariano Irpino, 2CNIO, Madrid, 3Stazione Zoologica Anton Dohrn Napoli, 4Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II Abstract In cancer microRNAs are often dysregulated with their expression patterns being correlated with clinically relevant tumor characteristics. Read More

Cantara S.1, Capezzone M.1, Marchisotta S.1, Busonero G.1, Filetti S.2, Pacini F.1 1Section of Endocrinology & Metabolism, Department of Internal Medicine, Endocrinology & Metabolism and Biochemistry, University of Siena, Siena, Italy, 2Department of Clinical Sciences, University of Rome, Rome, Italy Abstract Background: Differentiated non-medullary thyroid cancer (NMTC) is mostly sporadic, but the recurrence of familial Read More

Durand S.1, Ferraro-Peyret C.1, Selmi-Ruby S.1, Borson-Chazot F.1, 2, Rousset B.1, 2 1Inserm UMR 664, 2Thyroid Tumor Bank Organization, Hospices Civils de Lyon Abstract About 70% of papillary thyroid carcinomas (PTC) present a mutation of BRAF gene (BRAF T1799A) or a rearrangement of RET gene (RET/PTC). In this study, we examined whether PTC without BRAF Read More

Bassett J. H. D. 1, Boyde A.2, Howell G.T.3, Galliford M.T.1, Archanco M.1, Germain L.S.D.4, Galton A.V.4, Williams G.R.1 1Molecular Endocrinology Group, Imperial College London, London, UK, 2Centre for Oral Growth and Development, Queen Mary, University of London, London, UK, 3Eastman Dental Institute, University College London, London, UK, 4Department of Physiology, Dartmouth Medical School, Lebanon, Read More

Okrojek R., Grus F., Matheis N., Kahaly G.J. Gutenberg University Hospital, Mainz, Germany Abstract Background: Ocular and systemic autoimmune diseases induce changes in the protein profiles of tear fluid. To achieve a better understanding of the complex pathological processes in autoimmune Graves? orbitopathy (GO), more detailed information about these proteins had to be obtained. Hence, Read More