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Okrojek R., Grus F., Matheis N., Kahaly G.J. Gutenberg University Hospital, Mainz, Germany Abstract Background: Ocular and systemic autoimmune diseases induce changes in the protein profiles of tear fluid. To achieve a better understanding of the complex pathological processes in autoimmune Graves? orbitopathy (GO), more detailed information about these proteins had to be obtained. Hence, Read More

Brose S. M.1, Nellore A.2, Paziana K.3, Pappas-Paxinos M.3, Redlinger M.1, Flaherty T.K.1, Mandel J. S.2, Troxel J.A.4, Loevner A.L.5, Gupta-Abramson V.2 1Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA, 2Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA, 3Department of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA, USA, 4Department of Read More

Benhadi N.1, Wiersinga W. M.1, Reitsma J.2, Vrijkotte T.3, Bonsel G.3 1Department of Endocrinology and Metabolism, Academic medical Centre Amsterdam, The Netherlands, 2Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Centre Amsterdam, the Netherlands, 3Department of Social Science, Academic Medical Centre Amsterdam, The Netherlands Abstract Objective: To examine the relationship between maternal TSH and Read More

Nunez Miguel R.1, 2, Chirgadze D. Y.2, Sanders J.1, Blundell T. L.2, Furmaniak J.1, Rees Smith B.1 1FIRS Laboratories, RSR Ltd, Parc Ty Glas, Llanishen, Cardiff, UK; 2Department of Biochemistry, University of Cambridge, Cambridge, UK Abstract Autoantibodies in sera from patients with Graves’ disease mimic TSH binding to the TSH receptor (TSHR) and TSH biological Read More

Gopinath B.1, 2, Wang J.J.1,3, Kifley A.1, Leeder S.R.2, Mitchell P.1 1Centre for Vision Research, Department of Ophthalmology, Westmead Millennium Institute, University of Sydney, NSW, Australia, 2Australian Health Policy Institute, University of Sydney, Sydney, NSW, Australia, 3Centre for Eye Research Australia, Department of Ophthalmology, University of Melbourne, Melbourne, Victoria, Australia Abstract Objectives: Cardiovascular diseases are Read More

Viola D.1, Ugolini C.2, Lupi C.2, Biagini A.1, Giannini R.2, Romei C.1, Miccoli P.3, Pinchera A.1, Basolo F.2, Rossella E.1 1Department of Endocrinology, Azienda-Ospedaliero Universitaria Pisana, Pisa, Italy, 2Department of Oncology, Azienda-Ospedaliero Universitaria Pisana, Pisa, Italy, 3Department of Surgery, Azienda-Ospedaliero Universitaria Pisana, Pisa, Italy Abstract BRAFV600E mutation and RET/PTC rearrangements are the most frequent genetic Read More

Dentice M.1, Luongo C.1, Ambrosio R.1, Aristarco V.1, Casillo A.1, D?Ambrosio R.1, Mansi C.1, Fenzi G.1, Larsen PR.2, Salvatore D.1 1Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Universit? di Napoli “Federico II”, Naples, Italy, 2Division of Endocrinology, Brigham and Womens Hospital, Harvard, Boston, USA Abstract Thyroid hormone is a critical mediator of cellular metabolism Read More

Van der Deure W., Peeters R., Visser T. Department of Internal Medicine, Erasmus University Medical Center Rotterdam, The Netherlands Abstract As a prerequisite for intracellular processes like deiodination, sulfoconjugation or binding to the thyroid hormone (TH) receptor, TH is actively transported across the cell membrane by TH transporters. Several proteins can facilitate this transport, such Read More

Landa I.1, Montero-Conde C.1, Malanga D.2, 3, De Gisi S.3, Leton R.1, De Marco C.2, 3, Viglietto G.2, 3, Robledo M.1 1Hereditary Endocrine Cancer Group, CNIO, Spain, 2University Magna Graecia Catanzaro, Italy, 3Institute for Genetic Research IRGS, Ariano irpino (AV), Italy Abstract Background and Aims: CDKN1B (p27) is frequently downregulated in thyroid tumors, among many Read More