SHORT TELOMERES, HTERT GENE AMPLIFICATION AND INCREASED TELOMERASE ACTIVITY IN THE BLOOD OF FAMILIAL NON-MEDULLARY THYROID CANCER PATIENTS

Cantara S.1, Capezzone M.1, Marchisotta S.1, Busonero G.1, Filetti S.2, Pacini F.1 1Section of Endocrinology & Metabolism, Department of Internal Medicine, Endocrinology & Metabolism and Biochemistry, University of Siena, Siena, Italy, 2Department of Clinical Sciences, University of Rome, Rome, Italy Abstract Background: Differentiated non-medullary thyroid cancer (NMTC) is mostly sporadic, but the recurrence of familial Read More

MOLECULAR CHARACTERISTICS OF PAPILLARY THYROID CARCINOMAS WITHOUT BRAF MUTATION AND WITHOUT RET/PTC REARRANGEMENT: RELATIONSHIP WITH CLINICOPATHOLOGICAL FEATURES

Durand S.1, Ferraro-Peyret C.1, Selmi-Ruby S.1, Borson-Chazot F.1, 2, Rousset B.1, 2 1Inserm UMR 664, 2Thyroid Tumor Bank Organization, Hospices Civils de Lyon Abstract About 70% of papillary thyroid carcinomas (PTC) present a mutation of BRAF gene (BRAF T1799A) or a rearrangement of RET gene (RET/PTC). In this study, we examined whether PTC without BRAF Read More

INCREASED SKELETAL MINERALISATION IN MICE LACKING TYPE 2 IODOTHYRONINE DEIODINASE

Bassett J. H. D. 1, Boyde A.2, Howell G.T.3, Galliford M.T.1, Archanco M.1, Germain L.S.D.4, Galton A.V.4, Williams G.R.1 1Molecular Endocrinology Group, Imperial College London, London, UK, 2Centre for Oral Growth and Development, Queen Mary, University of London, London, UK, 3Eastman Dental Institute, University College London, London, UK, 4Department of Physiology, Dartmouth Medical School, Lebanon, Read More

MODIFIED PROTEOME PATTERNS OF TEAR FLUID IN GRAVES? ORBITOPATHY

Okrojek R., Grus F., Matheis N., Kahaly G.J. Gutenberg University Hospital, Mainz, Germany Abstract Background: Ocular and systemic autoimmune diseases induce changes in the protein profiles of tear fluid. To achieve a better understanding of the complex pathological processes in autoimmune Graves? orbitopathy (GO), more detailed information about these proteins had to be obtained. Hence, Read More

A PHASE II STUDY OF SORAFENIB IN ADVANCED METASTATIC THYROID CARCINOMA

Brose S. M.1, Nellore A.2, Paziana K.3, Pappas-Paxinos M.3, Redlinger M.1, Flaherty T.K.1, Mandel J. S.2, Troxel J.A.4, Loevner A.L.5, Gupta-Abramson V.2 1Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA, 2Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA, 3Department of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA, USA, 4Department of Read More

REACTIVATION OF THE P53 PATHWAY AND INDUCTION OF APOPTOSIS IN THYROID CARCINOMA CELLS BY THE CELL-PERMEABLE SYNTHETIC PEPTIDE P46, THE SMALL MOLECULE PRIMA-1 OR THE HDM2 INHIBITOR NUTLIN-3: THERAPEUTIC IMPLICATIONS

Hayden P.1, Kotoula V.2, McMillin W.D. 1, Negri J.1, Mitsiades S.C.1, Mitsiades N.1, 3 1Department of Medical Oncology, Dana Farber Cancer Institute, and Department of Medicine, Harvard Medical School, Boston MA, USA, 2Department of Pathology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece, 3Memorial Sloan Kettering Cancer Center, New York, USA Abstract Context: The Read More

HIGHER MATERNAL TSH LEVELS IN EARLY PREGNANCY ARE ASSOCIATED WITH INCREASED RISK FOR MISCARRIAGE, FETAL OR NEONATAL DEATH

Benhadi N.1, Wiersinga W. M.1, Reitsma J.2, Vrijkotte T.3, Bonsel G.3 1Department of Endocrinology and Metabolism, Academic medical Centre Amsterdam, The Netherlands, 2Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Centre Amsterdam, the Netherlands, 3Department of Social Science, Academic Medical Centre Amsterdam, The Netherlands Abstract Objective: To examine the relationship between maternal TSH and Read More

MOLECULAR MIMICRY BETWEEN THYROID STIMULATING AUOANTIBODY AND TSH BINDING TO THE TSH RECEPTOR

Nunez Miguel R.1, 2, Chirgadze D. Y.2, Sanders J.1, Blundell T. L.2, Furmaniak J.1, Rees Smith B.1 1FIRS Laboratories, RSR Ltd, Parc Ty Glas, Llanishen, Cardiff, UK; 2Department of Biochemistry, University of Cambridge, Cambridge, UK Abstract Autoantibodies in sera from patients with Graves’ disease mimic TSH binding to the TSH receptor (TSHR) and TSH biological Read More

THYROID FUNCTION STATUS, CARDIOVASCULAR RISK FACTORS AND MORTALITY IN OLDER PERSONS

Gopinath B.1, 2, Wang J.J.1,3, Kifley A.1, Leeder S.R.2, Mitchell P.1 1Centre for Vision Research, Department of Ophthalmology, Westmead Millennium Institute, University of Sydney, NSW, Australia, 2Australian Health Policy Institute, University of Sydney, Sydney, NSW, Australia, 3Centre for Eye Research Australia, Department of Ophthalmology, University of Melbourne, Melbourne, Victoria, Australia Abstract Objectives: Cardiovascular diseases are Read More

BRAFV600E MUTATION IS A BAD PROGNOSTIC FACTOR BOTH FOR THE OUTCOME AND SURVIVAL OF PAPILLARY THYROID CANCER PATIENTS

Viola D.1, Ugolini C.2, Lupi C.2, Biagini A.1, Giannini R.2, Romei C.1, Miccoli P.3, Pinchera A.1, Basolo F.2, Rossella E.1 1Department of Endocrinology, Azienda-Ospedaliero Universitaria Pisana, Pisa, Italy, 2Department of Oncology, Azienda-Ospedaliero Universitaria Pisana, Pisa, Italy, 3Department of Surgery, Azienda-Ospedaliero Universitaria Pisana, Pisa, Italy Abstract BRAFV600E mutation and RET/PTC rearrangements are the most frequent genetic Read More