MOLECULAR MIMICRY BETWEEN THYROID STIMULATING AUOANTIBODY AND TSH BINDING TO THE TSH RECEPTOR

Nunez Miguel R.1, 2, Chirgadze D. Y.2, Sanders J.1, Blundell T. L.2, Furmaniak J.1, Rees Smith B.1 1FIRS Laboratories, RSR Ltd, Parc Ty Glas, Llanishen, Cardiff, UK; 2Department of Biochemistry, University of Cambridge, Cambridge, UK Abstract Autoantibodies in sera from patients with Graves’ disease mimic TSH binding to the TSH receptor (TSHR) and TSH biological Read More

THYROID FUNCTION STATUS, CARDIOVASCULAR RISK FACTORS AND MORTALITY IN OLDER PERSONS

Gopinath B.1, 2, Wang J.J.1,3, Kifley A.1, Leeder S.R.2, Mitchell P.1 1Centre for Vision Research, Department of Ophthalmology, Westmead Millennium Institute, University of Sydney, NSW, Australia, 2Australian Health Policy Institute, University of Sydney, Sydney, NSW, Australia, 3Centre for Eye Research Australia, Department of Ophthalmology, University of Melbourne, Melbourne, Victoria, Australia Abstract Objectives: Cardiovascular diseases are Read More

BRAFV600E MUTATION IS A BAD PROGNOSTIC FACTOR BOTH FOR THE OUTCOME AND SURVIVAL OF PAPILLARY THYROID CANCER PATIENTS

Viola D.1, Ugolini C.2, Lupi C.2, Biagini A.1, Giannini R.2, Romei C.1, Miccoli P.3, Pinchera A.1, Basolo F.2, Rossella E.1 1Department of Endocrinology, Azienda-Ospedaliero Universitaria Pisana, Pisa, Italy, 2Department of Oncology, Azienda-Ospedaliero Universitaria Pisana, Pisa, Italy, 3Department of Surgery, Azienda-Ospedaliero Universitaria Pisana, Pisa, Italy Abstract BRAFV600E mutation and RET/PTC rearrangements are the most frequent genetic Read More

A FUNCTIONAL CROSS-TALK BETWEEN THYROID HORMONE AND SONIC HEDGEHOG PATHWAYS IN THE TUMORIGENESIS OF BASAL CELL CARCINOMA

Dentice M.1, Luongo C.1, Ambrosio R.1, Aristarco V.1, Casillo A.1, D?Ambrosio R.1, Mansi C.1, Fenzi G.1, Larsen PR.2, Salvatore D.1 1Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Universit? di Napoli “Federico II”, Naples, Italy, 2Division of Endocrinology, Brigham and Womens Hospital, Harvard, Boston, USA Abstract Thyroid hormone is a critical mediator of cellular metabolism Read More

ROLE OF OATP1 SUBFAMILY IN IODOTHYRONINE (SULFATE) TRANSPORT AND METABOLISM

Van der Deure W., Peeters R., Visser T. Department of Internal Medicine, Erasmus University Medical Center Rotterdam, The Netherlands Abstract As a prerequisite for intracellular processes like deiodination, sulfoconjugation or binding to the thyroid hormone (TH) receptor, TH is actively transported across the cell membrane by TH transporters. Several proteins can facilitate this transport, such Read More

A CASE-CONTROL STUDY OF CDKN1B (P27) POLYMORPHISMS IN THYROID CANCER IDENTIFIES A SIGNIFICANT SNP WITH AN EFFECT AT THE TRANSCRIPTIONAL LEVE

Landa I.1, Montero-Conde C.1, Malanga D.2, 3, De Gisi S.3, Leton R.1, De Marco C.2, 3, Viglietto G.2, 3, Robledo M.1 1Hereditary Endocrine Cancer Group, CNIO, Spain, 2University Magna Graecia Catanzaro, Italy, 3Institute for Genetic Research IRGS, Ariano irpino (AV), Italy Abstract Background and Aims: CDKN1B (p27) is frequently downregulated in thyroid tumors, among many Read More

SEVERE GRANULOMATOUS EXPERIMENTAL AUTOIMMUNE THYROIDITIS INDUCED BY IMMUNIZATION OF CBA/J(H-2K) MICE WITH HYDROPHOBIC INTERMEDIATES OF THYROGLOBULIN DISSOCIATION/UNFOLDING IN UREA

Arcaro A.1, D?Angelo D.2, Cetrangolo G.1, Luise C.2, Nucci R.3, Febbraio F.3, Fulciniti F.4, Formisano S.2, Gentile F.1 1Dipartimento di Scienze per la Salute, University del Molise, Campobasso, Italy, 2Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita Federico II, Napoli, Italy, 3Istituto di Biochimica delle Proteine del Consiglio Nazionale delle Ricerche, Napoli, Italy, 4Istituto Read More

SEASONAL VARIATION OF URINARY IODINE IN PREGNANT IRISH WOMEN

Smyth P. PA1, Burns R.1, Smith D. F.1, O? Herlihy C.2 1UCD Conway Institute, UCD, Belfield, Dublin, Ireland, 2National Maternity Hospital, Dublin, Ireland Abstract The relative absence of iodised salt from the Irish diet which latest figures indicate has declined from ~ 4% to <1% of salt sales has resulted in Urinary Iodine (UI) excretion Read More

INFLUENCE OF THE INTERVAL (24, 48, OR 72 HOURS) BETWEEN THE ADMINISTRATION OF 0.1 MG RECOMBINANT HUMAN THYROTROPIN (RHTSH) AND SUBSEQUENT THYROID RADIOIODINE UPTAKE IN NONTOXIC GOITER PATIENTS. EVALUATION BY A RANDOMIZED DOUBLE-BLINDED TRIAL

Fast S.1, Grupe P.2, Bonnema S.J.1, Heged?s L.1 1Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark, 2Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark Abstract Background: Recombinant human thyrotropin (rhTSH) approximately doubles thyroid radioiodine uptake (RAIU) in patients with nontoxic nodular goitre (NTNG), at large independent of rhTSH dose.Aim: To evaluate the Read More

US-GUIDED PERCUTANEOUS RADIOFREQUENCY THERMAL ABLATION FOR THE TREATMENT OF SOLID BENIGN HYPERFUNCTIONING OR COMPRESSIVE THYROID NODULES

Deandrea M., Limone P., Basso E., Mormile A., Ragazzoni F., Gamarra E., Spiezia S., Faggiano A., Colao A., Molinari F., Garberoglio R. Ospedale Mauriziano Umberto I di Torino, UOA di Endocrinologia e Centro per le Malattie della Tiroide Abstract Objectives Aim: of the study was to define the effectiveness and safety of US-guided percutaneous radiofrequency Read More