A FUNCTIONAL CROSS-TALK BETWEEN THYROID HORMONE AND SONIC HEDGEHOG PATHWAYS IN THE TUMORIGENESIS OF BASAL CELL CARCINOMA

Dentice M.1, Luongo C.1, Ambrosio R.1, Aristarco V.1, Casillo A.1, D?Ambrosio R.1, Mansi C.1, Fenzi G.1, Larsen PR.2, Salvatore D.1 1Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Universit? di Napoli “Federico II”, Naples, Italy, 2Division of Endocrinology, Brigham and Womens Hospital, Harvard, Boston, USA Abstract Thyroid hormone is a critical mediator of cellular metabolism Read More

ROLE OF OATP1 SUBFAMILY IN IODOTHYRONINE (SULFATE) TRANSPORT AND METABOLISM

Van der Deure W., Peeters R., Visser T. Department of Internal Medicine, Erasmus University Medical Center Rotterdam, The Netherlands Abstract As a prerequisite for intracellular processes like deiodination, sulfoconjugation or binding to the thyroid hormone (TH) receptor, TH is actively transported across the cell membrane by TH transporters. Several proteins can facilitate this transport, such Read More

A CASE-CONTROL STUDY OF CDKN1B (P27) POLYMORPHISMS IN THYROID CANCER IDENTIFIES A SIGNIFICANT SNP WITH AN EFFECT AT THE TRANSCRIPTIONAL LEVE

Landa I.1, Montero-Conde C.1, Malanga D.2, 3, De Gisi S.3, Leton R.1, De Marco C.2, 3, Viglietto G.2, 3, Robledo M.1 1Hereditary Endocrine Cancer Group, CNIO, Spain, 2University Magna Graecia Catanzaro, Italy, 3Institute for Genetic Research IRGS, Ariano irpino (AV), Italy Abstract Background and Aims: CDKN1B (p27) is frequently downregulated in thyroid tumors, among many Read More

SEVERE GRANULOMATOUS EXPERIMENTAL AUTOIMMUNE THYROIDITIS INDUCED BY IMMUNIZATION OF CBA/J(H-2K) MICE WITH HYDROPHOBIC INTERMEDIATES OF THYROGLOBULIN DISSOCIATION/UNFOLDING IN UREA

Arcaro A.1, D?Angelo D.2, Cetrangolo G.1, Luise C.2, Nucci R.3, Febbraio F.3, Fulciniti F.4, Formisano S.2, Gentile F.1 1Dipartimento di Scienze per la Salute, University del Molise, Campobasso, Italy, 2Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita Federico II, Napoli, Italy, 3Istituto di Biochimica delle Proteine del Consiglio Nazionale delle Ricerche, Napoli, Italy, 4Istituto Read More

SEASONAL VARIATION OF URINARY IODINE IN PREGNANT IRISH WOMEN

Smyth P. PA1, Burns R.1, Smith D. F.1, O? Herlihy C.2 1UCD Conway Institute, UCD, Belfield, Dublin, Ireland, 2National Maternity Hospital, Dublin, Ireland Abstract The relative absence of iodised salt from the Irish diet which latest figures indicate has declined from ~ 4% to <1% of salt sales has resulted in Urinary Iodine (UI) excretion Read More

INFLUENCE OF THE INTERVAL (24, 48, OR 72 HOURS) BETWEEN THE ADMINISTRATION OF 0.1 MG RECOMBINANT HUMAN THYROTROPIN (RHTSH) AND SUBSEQUENT THYROID RADIOIODINE UPTAKE IN NONTOXIC GOITER PATIENTS. EVALUATION BY A RANDOMIZED DOUBLE-BLINDED TRIAL

Fast S.1, Grupe P.2, Bonnema S.J.1, Heged?s L.1 1Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark, 2Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark Abstract Background: Recombinant human thyrotropin (rhTSH) approximately doubles thyroid radioiodine uptake (RAIU) in patients with nontoxic nodular goitre (NTNG), at large independent of rhTSH dose.Aim: To evaluate the Read More

US-GUIDED PERCUTANEOUS RADIOFREQUENCY THERMAL ABLATION FOR THE TREATMENT OF SOLID BENIGN HYPERFUNCTIONING OR COMPRESSIVE THYROID NODULES

Deandrea M., Limone P., Basso E., Mormile A., Ragazzoni F., Gamarra E., Spiezia S., Faggiano A., Colao A., Molinari F., Garberoglio R. Ospedale Mauriziano Umberto I di Torino, UOA di Endocrinologia e Centro per le Malattie della Tiroide Abstract Objectives Aim: of the study was to define the effectiveness and safety of US-guided percutaneous radiofrequency Read More

RADIOFREQUENCY THERMAL ABLATION IN THE TREATMENT OF THYROID NODULES: 2 YEAR FOLLOW-UP

Spiezia S.1, Faggiano A.2, Ramundo V.2, Garberoglio R.3, Caiazzo C.1, Assanti A. P.1, Deandrea M.3, Limone P.P.3, Lombardi G.2, Colao A.2 1Unit of Ultrasound Guided & Neck Pathology Surgery, “S. Maria del Popolo degli Incurabili” Hospital, Naples, Italy, 2Department of Molecular and Clinical Endocrinology and Oncology, “Federico II” University of Naples, Italy, 3Unit of Endocrinology Read More

NO LINK BETWEEN X CHROMOSOME INACTIVATION PATTERN AND SIMPLE GOITRE IN FEMALES. EVIDENCE FROM A TWIN STUDY

Brix T.1, Hansen P.2, Knudsen G.3, Kringen M. K.3, Kyvik K. O.2, Sorensen T. H. I. A.4, Orstavik K. H.5, Heged?s L.1 1Department of Endocrinology and Metabolism, Odense University Hospital,Odense, Denmark, 2The Danish Twin Registry, University of Southern Denmark, Odense, Denmark, 3Faculty Division Rikshospitalet, University of Oslo, Oslo, Norway, 4Danish Epidemiology Science Centre, Institute of Read More

HYPOTHYROIDISM HAS AN ADVERSE EFFECT ON HUMAN SPERMATOGENESIS: A PROSPECTIVE, CONTROLLED STUDY

Krassas G. E.1, Pontikides N.1, Papadopoulou F.1, Tziomalos K.1, Zegeniadou T.1, Hammadeh M.2 1Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, Thessaloniki, Greece, 2Department of Obstetrics and Gynaecology, University of Saarland, Homburg Saar, Germany Abstract Little is known about the effects of hypothyroidism on human spermatogenesis. Only few uncontrolled studies have published so far.Aim: Read More