RADIOFREQUENCY THERMAL ABLATION IN THE TREATMENT OF THYROID NODULES: 2 YEAR FOLLOW-UP

Spiezia S.1, Faggiano A.2, Ramundo V.2, Garberoglio R.3, Caiazzo C.1, Assanti A. P.1, Deandrea M.3, Limone P.P.3, Lombardi G.2, Colao A.2 1Unit of Ultrasound Guided & Neck Pathology Surgery, “S. Maria del Popolo degli Incurabili” Hospital, Naples, Italy, 2Department of Molecular and Clinical Endocrinology and Oncology, “Federico II” University of Naples, Italy, 3Unit of Endocrinology Read More

NO LINK BETWEEN X CHROMOSOME INACTIVATION PATTERN AND SIMPLE GOITRE IN FEMALES. EVIDENCE FROM A TWIN STUDY

Brix T.1, Hansen P.2, Knudsen G.3, Kringen M. K.3, Kyvik K. O.2, Sorensen T. H. I. A.4, Orstavik K. H.5, Heged?s L.1 1Department of Endocrinology and Metabolism, Odense University Hospital,Odense, Denmark, 2The Danish Twin Registry, University of Southern Denmark, Odense, Denmark, 3Faculty Division Rikshospitalet, University of Oslo, Oslo, Norway, 4Danish Epidemiology Science Centre, Institute of Read More

HYPOTHYROIDISM HAS AN ADVERSE EFFECT ON HUMAN SPERMATOGENESIS: A PROSPECTIVE, CONTROLLED STUDY

Krassas G. E.1, Pontikides N.1, Papadopoulou F.1, Tziomalos K.1, Zegeniadou T.1, Hammadeh M.2 1Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, Thessaloniki, Greece, 2Department of Obstetrics and Gynaecology, University of Saarland, Homburg Saar, Germany Abstract Little is known about the effects of hypothyroidism on human spermatogenesis. Only few uncontrolled studies have published so far.Aim: Read More

THYROID DYSFUNCTION, AGING AND CARDIOVASCULAR RISK

Borissova A. M., Kovatcheva R., Shinkov A., Atanassova A., Vlahov J., Aslanova N., Dakovska L., Vukov M. University Hospital of Endocrinology, National Center of Medical Information, Medical University Sofia, Bulgaria Abstract Thyroid dysfunction is a known factor for cardiovascular morbidity. It has been shown that both subclinical hypothyroidism and hyperthyroidism increase significantly cardiovascular risk. Material Read More

ASSOCIATION OF ???ROID FUNCTION WITH MEASURES OF ADIPOSITY AND METABOLIC PROFILE IN APPARENTLY HEALTHY INDIVIDUALS

Saltiki K.1, Voidonikola P.2, Mantzou E.3, Stamatelopoulos K.2, Papamichael C.2, Alevizaki M.1 1Endocrine Unit, Dept Clinical Therapeutics, Alexandra Hospital, Athens University School of Medicine, 2Vascular Laboratory, Dept of Medical Therapeutics, Alexandra Hospital, Athens University School of Medicine, 3Endocrine Unit, Evgenidion Hospital, Athens University School of Medicine Abstract Objectives: Although TSH has been positively associated with Read More

DISTURBED ALTERNATIVE SPLICING OF TYPE 1 DEIODINASE IN RENAL CANCER: POTENTIAL ROLE OF SPLICING FACTORS SF2/ASF AND HNRNPA1

Piekielko-Witkowska A.1, Master A.1, Wojcicka A.1, Lampkowska J.1, Poplawski P.1, Brozda I.1, Tanski Z.2, Nauman A.1 1Medical Center of Postgraduate Education, Department of Biochemistry and Molecular Biology, ul. Warsaw, Poland, 2Specialistic Hospital, Ostroleka, Poland Abstract Background and aims: Type 1 deiodinase (D1) catalyses synthesis of triiodothyronine (T3) which regulates the expression of many tumor suppressor Read More

NOVEL PHYSIOLOGICAL IMPLICATIONS OF CO-TRANSPORT OF (SULFATED) IODOTHYRONINES AND TAUROCHOLATE BY LIVER SLC10A1

Visser W. E.1, Wong W. S.1, Friesema E. C. H.1, Geyer J.2, Visser T. J.1 1Internal Medicine, Erasmus MC, Rotterdam, The Netherlands, 2Institute of Pharmacology and Toxicology, Justus-Liebig-University of Giessen, Giessen, Germany Abstract Deiodination is an important metabolic pathway for iodothyronines and their sulfates that takes place intracellularly. Therefore, transport of (sulfated) iodothyronines across the Read More

EFFECTS OF SELENIUM AND IODINE DEPLETION/REPLETION ON BEHAVIORS OF ADULT C57BL/6 MICE

Li J.1,2, Peters J.P.1, Houbeau G.1, Bister J.L.3, Rivera M.T.4, Vanderpas J.1,4, Huynen M.C.5, Wolff F.6, Mercier M.1 1Departments of Psychology, 3Laboratory of Animal Physiology, 4Unit of Epidemiology, University of Namur, Namur, Belgium, 2Department of Radiation Medicine, Faculty of Preventive Medicine, The Fourth Military Medical University, Xi’an, P.R.China, 5Behavioural Biology Unit, Department of Environmental Sciences, Read More

IN PENDRED?S SYNDROME, LOSS OF THYROID IODINATION IS ASSOCIATED WITH MISLOCALIZATION AND UPREGULATION OF PROTEINS INVOLVED IN IODINE METABOLISM AND WITH CELL TOXICITY: A MORPHOLOGICAL STUDY

Senou M.1, Khalifa C.1, Timmesch M.1, Van Sande J.2, Dumont J.2, Audinot J.N.3, Many M.C.1 1Laboratoire de Morphologie Experimentale, UCL, Brussels, Belgium, 2IRIBHM, ULB, Brussels, Belgium, 3Laboratoire d analyse des materiaux, CRP G. Lippmann, Luxembourg Abstract About 50% of patients with Pendreds syndrome develop goiter and hypothyroidism with iodination defect, due to the lack of Read More

HORMONAL REGULATION OF IODIDE UPTAKE IN PLACENTAL PRIMARY CULTURES

Burns R.1, Smith D.F.1, O? Herlihy C.2, Smyth P. PA.1 1UCD Conway Institute, UCD, Belfield, Dublin, Ireland, 2National Maternity Hospital, Dublin, Ireland Abstract Maintenance of adequate iodine supply to the developing fetus is dependent not only on maternal dietary iodine intake but also active placental iodide transport. The sodium iodide symporter (NIS) gene and protein Read More