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Fugazzola L.1, Cortinovis F.2, Zamproni I.2, Vigone M. C.2, Muzza M.1, Cordella D.3, Beck-Peccoz P.1, Refetoff S.4, Weber G.2, Persani L.3 1Dept. of Medical Sciences, Endocrine Unit University of Milan, IRCCS Fondazione Policlinico, Milan, Italy, 2Department of Pediatrics, Lab of Pediatric Endocrinology University Vita-Salute S. Raffaele, Milan, Italy, 3Dept. of Medical Sciences University of Milan, Read More

Saltiki K.1, Voidonikola P.2, Mantzou E.3, Stamatelopoulos K.2, Papamichael C.2, Alevizaki M.1 1Endocrine Unit, Dept Clinical Therapeutics, Alexandra Hospital, Athens University School of Medicine, 2Vascular Laboratory, Dept of Medical Therapeutics, Alexandra Hospital, Athens University School of Medicine, 3Endocrine Unit, Evgenidion Hospital, Athens University School of Medicine Abstract Objectives: Although TSH has been positively associated with Read More

Piekielko-Witkowska A.1, Master A.1, Wojcicka A.1, Lampkowska J.1, Poplawski P.1, Brozda I.1, Tanski Z.2, Nauman A.1 1Medical Center of Postgraduate Education, Department of Biochemistry and Molecular Biology, ul. Warsaw, Poland, 2Specialistic Hospital, Ostroleka, Poland Abstract Background and aims: Type 1 deiodinase (D1) catalyses synthesis of triiodothyronine (T3) which regulates the expression of many tumor suppressor Read More

Visser W. E.1, Wong W. S.1, Friesema E. C. H.1, Geyer J.2, Visser T. J.1 1Internal Medicine, Erasmus MC, Rotterdam, The Netherlands, 2Institute of Pharmacology and Toxicology, Justus-Liebig-University of Giessen, Giessen, Germany Abstract Deiodination is an important metabolic pathway for iodothyronines and their sulfates that takes place intracellularly. Therefore, transport of (sulfated) iodothyronines across the Read More

Li J.1,2, Peters J.P.1, Houbeau G.1, Bister J.L.3, Rivera M.T.4, Vanderpas J.1,4, Huynen M.C.5, Wolff F.6, Mercier M.1 1Departments of Psychology, 3Laboratory of Animal Physiology, 4Unit of Epidemiology, University of Namur, Namur, Belgium, 2Department of Radiation Medicine, Faculty of Preventive Medicine, The Fourth Military Medical University, Xi’an, P.R.China, 5Behavioural Biology Unit, Department of Environmental Sciences, Read More

Senou M.1, Khalifa C.1, Timmesch M.1, Van Sande J.2, Dumont J.2, Audinot J.N.3, Many M.C.1 1Laboratoire de Morphologie Experimentale, UCL, Brussels, Belgium, 2IRIBHM, ULB, Brussels, Belgium, 3Laboratoire d analyse des materiaux, CRP G. Lippmann, Luxembourg Abstract About 50% of patients with Pendreds syndrome develop goiter and hypothyroidism with iodination defect, due to the lack of Read More

Burns R.1, Smith D.F.1, O? Herlihy C.2, Smyth P. PA.1 1UCD Conway Institute, UCD, Belfield, Dublin, Ireland, 2National Maternity Hospital, Dublin, Ireland Abstract Maintenance of adequate iodine supply to the developing fetus is dependent not only on maternal dietary iodine intake but also active placental iodide transport. The sodium iodide symporter (NIS) gene and protein Read More

Mirmiran P. Salarkia N., Hedayati M., Azizi F. Endocrine Research Center, National Nutrition and Food Technology Research Institute, Shaheed Beheshti University and Medical Services, Tehran, Iran Abstract Objective: The purpose of this study was to evaluate the effect of 10 years iodine supplementation on the IDD impact indicators in the iodine deficient schoolchildren of villages Read More

Boelen A.1, Kwakkel J.1, Chassande O.2, Fliers E.1 1Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands, 2INSERM U 577, Universite Victor Segalen Bordeaux 2, Bordeaux, France Abstract Acute illness in mice profoundly affects hypothalamic type 2 deiodinase (D2) and thyrotropin-releasing hormone (TRH) mRNA expression. TRH expression is regulated by T3, predominantly via the thyroid Read More

Jensen E.1, Blaabjerg O.1, Hyltoft Petersen P.2, Abrahamsen B.3, Brixen K.3, Heged?s L.3 1Department of Clinical Biochemistry, Odense University Hospital, Odense, Denmark, 2NOKLUS, Norwegian quality improvement of primary care laboratories, Division for General Practice, University of Bergen, Bergen, Norway, 3Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark Abstract Purpose: To investigate how stable Read More