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Vannucchi G.1, Campi I.1, Bonomi M.1, Covelli D.2, Dazzi D.2, Currò N.2, Bonara P.2, Persani L.1, Beck-Peccoz P.1, Salvi M.1 1Dept. of Medical Sciences, University of Milan, 1st. Auxologico Italiano IRCCS and Fondazione Ospedale Policlinico IRCCS, Milano, 2Ophthalmology, Internal Medicine, University of Milan Abstract Circulating proinflammatory cytokines and CXCL10 have been reported to be elevated Read More

Ventura P.S.1, Azcona C.2, Clemente M.3, Albisu M.3, Audi L.3, Carrascosa A.3 Visser T. J.1, Moreno J.C. 1 1Dept. Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands, 2Pediatrics, University Clinic of Navarra, Pamplona, Spain, 3Pediatric Endocrinology, Vall d Hebron Hospital, Barcelona, Spain Abstract Generation of H2O2 at the apical membrane of thyroid cells is essential Read More

Ventura P.S.1, Cavarzere P.2, Albisu M.3, Audi L.3, Drop S.L.S.4, Carrascosa A.3, Leger J.5, Polak M.2, Visser T.J.1, Moreno J.C.1 1Dept of Internal Medicine, Erasmus Medical Cente. Rotterdam, The Netherlands, 2Pediatric Endocrinology Necker-Enfants Malades Hospital, Paris, France, 3Pediatric Endocrinology, Vall dHebron Hospital, Barcelona, Spain, 4Pediatric Endocrinology, Sophia Children Hospital, Rotterdam, The Netherlands, 5Pediatric Endocrinology, Robert Read More

Norden M. M., Carlsson T., Nilsson M. Biomedicine, Sahlgrenska Academy Gothenburg University, Gothenburg, Sweden Abstract Uptake and accumulation of iodide is the most prominent feature of the thyroid gland. The function is regulated by both positive and negative signals acting on the NIS promoter, TSH being the strongest enhancer. Recent in vitro findings indicate that Read More

Mueller S.1, Szkudlinski W.M.2, Jaeschke H.1, Kleinau G.3, Krause G.3, Paschke R.1 1III Medical Department, University of Leipzig, Leipzig, Germany, 2Trophogen, Inc., Rockville, MD 20850, USA, 3Leibniz-Institut f?r Molekulare Pharmakologie, Berlin, Germany Abstract Objectives: The human TSHR hinge region links the extracellular LRR domain with the transmembrane domain. Previously published crystal structures of a part Read More

Zoenen M.1, Urizar E.2, Vassart G.3, Costagliola S.1 1IRIBHM, Universite Libre de Bruxelles, Campus Erasme, B-1070 Brussels, Belgium, 2Center for Molecular Recognition, Columbia University, New York, USA, 3Service de Genetique Medicale, Hopital Erasme, Brussels, Belgium Abstract The TSH receptor (TSHR) is a G protein-coupled receptor (GPCR) with a division of labor between agonist binding, by Read More

Opitz R., Lorenz C., Trubiroha A., Kloas W. Department of Inland Fisheries, Leibniz-Institute of Freshwater Ecology and Inland Fisheries, Berlin, Germany Abstract function, molecular data on thyroid responses to TSH are still mainly limited to a few mammalian model species. To gain insights into molecular mechanisms of thyroid function in non-mammalian vertebrates, we used real-time Read More

Recacha P.1, Santisteban P.1 1Endocrine and Nervous System physiopathology, Instituto de Investigaciones Biomedicas, CSIC-UAM, Madrid, Spain Abstract The study of the mechanisms by which different cell types are specified from the embryonic germ layers has been the subject of recent investigation. Concerning the thyroid organogenesis, available data are mainly about the expression of Titf1, Foxe1 Read More

Ponto K.A.1, Pitz S.1, Hommel G.1, Kahaly G.J.1 1Gutenberg University, Mainz, Germany Abstract Background: Facial disfigurement of Graves? orbitopathy (GO) is accompanied by restrictions in private and professional life. Aim of this prospective study was to determine the relationship between ocular findings, thyroid function and autoantibodies, quality of life, and working ability in GO.Methods: On Read More

Jurecka-Lubieniecka B.1, Polanska J.2, Kula D.1, Krawczyk A.1, Zebracka – Gala J.1, Gubala E.1, Stechly T.1, Tyszkiewicz T.1, Jarzab B.1 1MSC Memorial Cancer Center and Institute of Oncology, Gliwice, Poland, 2Institute of Automatic Control, Silesian University of Technology, Gliwice, Poland Abstract Background: While the multigene predisposition to Graves disease (GD) is well known, although not Read More