Author: admin

Opitz R., Lorenz C., Trubiroha A., Kloas W. Department of Inland Fisheries, Leibniz-Institute of Freshwater Ecology and Inland Fisheries, Berlin, Germany Abstract function, molecular data on thyroid responses to TSH are still mainly limited to a few mammalian model species. To gain insights into molecular mechanisms of thyroid function in non-mammalian vertebrates, we used real-time Read More

Mirmiran P. Salarkia N., Hedayati M., Azizi F. Endocrine Research Center, National Nutrition and Food Technology Research Institute, Shaheed Beheshti University and Medical Services, Tehran, Iran Abstract Objective: The purpose of this study was to evaluate the effect of 10 years iodine supplementation on the IDD impact indicators in the iodine deficient schoolchildren of villages Read More

Boelen A.1, Kwakkel J.1, Chassande O.2, Fliers E.1 1Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands, 2INSERM U 577, Universite Victor Segalen Bordeaux 2, Bordeaux, France Abstract Acute illness in mice profoundly affects hypothalamic type 2 deiodinase (D2) and thyrotropin-releasing hormone (TRH) mRNA expression. TRH expression is regulated by T3, predominantly via the thyroid Read More

Jensen E.1, Blaabjerg O.1, Hyltoft Petersen P.2, Abrahamsen B.3, Brixen K.3, Heged?s L.3 1Department of Clinical Biochemistry, Odense University Hospital, Odense, Denmark, 2NOKLUS, Norwegian quality improvement of primary care laboratories, Division for General Practice, University of Bergen, Bergen, Norway, 3Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark Abstract Purpose: To investigate how stable Read More

Fugazzola L.1, Cortinovis F.2, Zamproni I.2, Vigone M. C.2, Muzza M.1, Cordella D.3, Beck-Peccoz P.1, Refetoff S.4, Weber G.2, Persani L.3 1Dept. of Medical Sciences, Endocrine Unit University of Milan, IRCCS Fondazione Policlinico, Milan, Italy, 2Department of Pediatrics, Lab of Pediatric Endocrinology University Vita-Salute S. Raffaele, Milan, Italy, 3Dept. of Medical Sciences University of Milan, Read More

Ventura P.S.1, Azcona C.2, Clemente M.3, Albisu M.3, Audi L.3, Carrascosa A.3 Visser T. J.1, Moreno J.C. 1 1Dept. Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands, 2Pediatrics, University Clinic of Navarra, Pamplona, Spain, 3Pediatric Endocrinology, Vall d Hebron Hospital, Barcelona, Spain Abstract Generation of H2O2 at the apical membrane of thyroid cells is essential Read More

Ventura P.S.1, Cavarzere P.2, Albisu M.3, Audi L.3, Drop S.L.S.4, Carrascosa A.3, Leger J.5, Polak M.2, Visser T.J.1, Moreno J.C.1 1Dept of Internal Medicine, Erasmus Medical Cente. Rotterdam, The Netherlands, 2Pediatric Endocrinology Necker-Enfants Malades Hospital, Paris, France, 3Pediatric Endocrinology, Vall dHebron Hospital, Barcelona, Spain, 4Pediatric Endocrinology, Sophia Children Hospital, Rotterdam, The Netherlands, 5Pediatric Endocrinology, Robert Read More

Norden M. M., Carlsson T., Nilsson M. Biomedicine, Sahlgrenska Academy Gothenburg University, Gothenburg, Sweden Abstract Uptake and accumulation of iodide is the most prominent feature of the thyroid gland. The function is regulated by both positive and negative signals acting on the NIS promoter, TSH being the strongest enhancer. Recent in vitro findings indicate that Read More

Mueller S.1, Szkudlinski W.M.2, Jaeschke H.1, Kleinau G.3, Krause G.3, Paschke R.1 1III Medical Department, University of Leipzig, Leipzig, Germany, 2Trophogen, Inc., Rockville, MD 20850, USA, 3Leibniz-Institut f?r Molekulare Pharmakologie, Berlin, Germany Abstract Objectives: The human TSHR hinge region links the extracellular LRR domain with the transmembrane domain. Previously published crystal structures of a part Read More

Zoenen M.1, Urizar E.2, Vassart G.3, Costagliola S.1 1IRIBHM, Universite Libre de Bruxelles, Campus Erasme, B-1070 Brussels, Belgium, 2Center for Molecular Recognition, Columbia University, New York, USA, 3Service de Genetique Medicale, Hopital Erasme, Brussels, Belgium Abstract The TSH receptor (TSHR) is a G protein-coupled receptor (GPCR) with a division of labor between agonist binding, by Read More