IN SITU DETECTION OF MICRORNAS 146B, 221 AND 222 IN FORMALIN-FIXED, PARAFFIN-EMBEDDED HUMAN CARCINOMA TISSUES REVEALS SPECIFIC EXPRESSION PATTERNS IN THYROID CARCINOMAS

Kotoula V.1, Charalambous E.1, Koletsa T.1, Pliakos I.1, Karayannopoulou G.1, Karkavelas G.1, Mitsiades S.C.2, Mitsiades N.2, 3 1Dept. of Pathology, School of Medicine, Aristotle University, Thessaloniki, Greece, 2Dept. of Medical Oncology, Dana Farber Cancer Institute, and Dept. of Medicine, Harvard Medical School, Boston MA, USA, 3Memorial Sloan Kettering Cancer Center, New York, USA Abstract Context: Read More

THE ROLE OF SONIC HEDGEHOG PATHWAY IN THYROID ORGANOGENESIS

Recacha P.1, Santisteban P.1 1Endocrine and Nervous System physiopathology, Instituto de Investigaciones Biomedicas, CSIC-UAM, Madrid, Spain Abstract The study of the mechanisms by which different cell types are specified from the embryonic germ layers has been the subject of recent investigation. Concerning the thyroid organogenesis, available data are mainly about the expression of Titf1, Foxe1 Read More

PSYCHOSOCIAL ASSESSMENT IN 250 CONSECUTIVE PATIENTS WITH GRAVES? ORBITOPATHY

Ponto K.A.1, Pitz S.1, Hommel G.1, Kahaly G.J.1 1Gutenberg University, Mainz, Germany Abstract Background: Facial disfigurement of Graves? orbitopathy (GO) is accompanied by restrictions in private and professional life. Aim of this prospective study was to determine the relationship between ocular findings, thyroid function and autoantibodies, quality of life, and working ability in GO.Methods: On Read More

GENETIC AND NON GENETIC RISK FACTORS FOR THE OCCURRENCE OF OPHTALMOPATHY IN THE COURSE OF GRAVES DISEASE

Jurecka-Lubieniecka B.1, Polanska J.2, Kula D.1, Krawczyk A.1, Zebracka – Gala J.1, Gubala E.1, Stechly T.1, Tyszkiewicz T.1, Jarzab B.1 1MSC Memorial Cancer Center and Institute of Oncology, Gliwice, Poland, 2Institute of Automatic Control, Silesian University of Technology, Gliwice, Poland Abstract Background: While the multigene predisposition to Graves disease (GD) is well known, although not Read More

THE EFFECT OF RITUXIMAB ON IL-6/SIL-6R AND CXCL10 SECRETION AND TSH-RECEPTOR STIMULATING ANTIBODIES IN PATIENTS WITH ACTIVE THYROID-ASSOCIATED ORBITOPATHY

Vannucchi G.1, Campi I.1, Bonomi M.1, Covelli D.2, Dazzi D.2, Currò N.2, Bonara P.2, Persani L.1, Beck-Peccoz P.1, Salvi M.1 1Dept. of Medical Sciences, University of Milan, 1st. Auxologico Italiano IRCCS and Fondazione Ospedale Policlinico IRCCS, Milano, 2Ophthalmology, Internal Medicine, University of Milan Abstract Circulating proinflammatory cytokines and CXCL10 have been reported to be elevated Read More

INDUCTION OF HYALURONAN PRODUCTION IN DIFFERENTIATED HUMAN ORBITAL FIBROBLASTS BY FORSKOLIN, BUT NOT BY TSH OR GRAVES IGG

Van Zeijl C.J.J.1, Surovtseva O.V.1, Mourits M.P.2, Fliers E.1, Wiersinga W.M.1, Boelen A.1 1Department of Endocrinology & Metabolism, Academical Medical Center, University of Amsterdam, The Netherlands, 2Orbita Center, Department of Ophthalmology, Academical Medical Center, University of Amsterdam, The Netherlands Abstract Introduction: TSH receptors (TSHR) expressed by differentiated orbital fibroblasts (DOF) may be involved in the Read More

EXPRESSION OF TH1 (CXCL9, CXCL11) AND TH2 (CCL2) CHEMOKINES IN THYROCYTES, FIBROBLASTS AND PREADIPOCYTES FROM PATIENTS WITH GRAVES OPHTHALMOPATHY; MODULATION BY PPARGAMMA AGONISTS

Antonelli A.1, Fallahi P.1, Ferrari S.M.1, Romagnani P.2, Franceschini S.S.3, Serio M.2, Ferrannini E.1 1Department of Internal Medicine, University of Pisa; Pisa; Italy, 2Department of Clinical Pathophysiology, Endocrinology Unit, University of Florence, Florence, Italy, 3Otorhinolaryngology Unit, University of Pisa-School of Medicine, Pisa, Italy Abstract Objectives & Methods: CXC Th1-chemokines and CCL Th2-chemokines play an important Read More

IDENTIFICATION OF KEY RESIDUES ON THYROID PEROXIDASE CONTRIBUTING TO THE BINDING OF MOUSE MONOCLONAL ANTIBODIES SPECIFIC FOR IMMUNODOMINANT REGIONS

Godlewska M.1, Gora M.1, 2, Krasuska W.1, Banga J.P.3, Gardas A.1 1Department of Biochemistry and Molecular Biology, Medical Centre of Postgraduate Education, Warsaw, Poland, 2Department of Genetics, Institute of Biochemistry and Biophysics PAS, Warsaw, Poland, 3Division of Gene and Cell Based Therapy, King’s College London School of Medicine, London, UK Abstract The major target autoantigen Read More

CLINICAL EVALUATION OF THE FIRST AUTOMATED TSH RECEPTOR AUTOANTIBODY ASSAY: AN INTERNATIONAL MULTICENTER TRIAL

Schott M.1, Broecker-Preuss M.2, Casati M.3, van Helden J.5, Inomata K.6, Kratzsch J.7, Mann K.2, Camara Mas J.4, Miyazaki N.8, Navarro Moreno M. A.4, Murakami T.6, Yoshimura Noh J.8, Roth H.J.9, Scherbaum A.W.1, Hermsen D.10 1Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, 2 Department of Endocrinology, University Hospital Essen, Essen, Germany, 3A.O. San Read More

HUMAN HERPESVIRUS TYPE 6 (HHV6) AND 7 (HHV7) INFECTION MAY INCREASE THE SUSCEPTIBILITY TO GRAVES? DISEASE IN INDIVIDUALS WITH INHERITED DIMINISHED TP53 APOPTOTIC FUNCTION

Leite J.L.1, Bufalo N.E.1, Santos R.B.2, Romaldini J.H.2, Ward L.S.1 1Molecular Genetics of Cancer Laboratory, Department of Internal Medicine, Medical Science School – FCM, State University of Campinas – UNICAMP, State of Sao Paulo, Brazil, 2Endocrinology, Pontifica Universidade Catolica de Campinas, Sao Paulo, Brazil Abstract Graves\ disease (GD) is a multifactorial condition presumably provoked by Read More