A LINK BETWEEN X CHROMOSOME INACTIVATION PATTERN AND SUBCLINICAL AUTOIMMUNE THYROID DISEASE EVIDENCE FROM A TWIN STUDY

Hansen P.S.1, Brix T.H.2, Knudsen G.P.S.3, Kringen M.K.3, Kyvik K O.1, Sorensen T. H.I.A.4, Orstavik K.H.5, Heged?s L.2 1The Danish Twin Registry, University of Southern Denmark, Odense, Denmark, 2Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark, 3Faculty Division Rikshospitalet, University of Oslo, Oslo, Norway, 4Danish Epidemiology Science Centre, Institute of Preventive Medicine, Copenhagen Read More

TELOMERASE-DRIVEN EXPRESSION OF THE SODIUM IODIDE SYMPORTER (NIS) FOR IN VIVO RADIOIODIDE IMAGING AND TREATMENT OF CANCER: A NEW BROAD-SPECTRUM NIS-MEDIATED ANTITUMOUR APPROACH

Riesco-Eizaguirre G.1, De La Vieja A.2, Rodriguez-Garcia I.2, Martin-Duque P.3, Vassaux G.4, Santisteban P.2 1Hospital Universitario La Paz, Madrid, Spain, 2Instituto de Investigaciones Biomedicas “Alberto Sols”, CSIC-UAM, Madrid, Spain, 3Departamento de Biotecnologia, Universidad Francisco de Vitoria, Madrid, Spain, 4Centre for Molecular Oncology, Institute of Cancer, Queen Mary’s School of Medicine and Dentistry, London, UK Abstract Read More

HUMAN HERPESVIRUS TYPE 6 (HHV6) AND 7 (HHV7) INFECTION MAY INCREASE THE SUSCEPTIBILITY TO GRAVES? DISEASE IN INDIVIDUALS WITH INHERITED DIMINISHED TP53 APOPTOTIC FUNCTION

Leite J.L.1, Bufalo N.E.1, Santos R.B.2, Romaldini J.H.2, Ward L.S.1 1Molecular Genetics of Cancer Laboratory, Department of Internal Medicine, Medical Science School – FCM, State University of Campinas – UNICAMP, State of Sao Paulo, Brazil, 2Endocrinology, Pontifica Universidade Catolica de Campinas, Sao Paulo, Brazil Abstract Graves\ disease (GD) is a multifactorial condition presumably provoked by Read More

IN SITU DETECTION OF MICRORNAS 146B, 221 AND 222 IN FORMALIN-FIXED, PARAFFIN-EMBEDDED HUMAN CARCINOMA TISSUES REVEALS SPECIFIC EXPRESSION PATTERNS IN THYROID CARCINOMAS

Kotoula V.1, Charalambous E.1, Koletsa T.1, Pliakos I.1, Karayannopoulou G.1, Karkavelas G.1, Mitsiades S.C.2, Mitsiades N.2, 3 1Dept. of Pathology, School of Medicine, Aristotle University, Thessaloniki, Greece, 2Dept. of Medical Oncology, Dana Farber Cancer Institute, and Dept. of Medicine, Harvard Medical School, Boston MA, USA, 3Memorial Sloan Kettering Cancer Center, New York, USA Abstract Context: Read More

INFLUENCES OF SHORT-TERM HYPOTHYROIDISM IN BODY WEIGHT, LIPID METABOLISM AND BLOOD PRESSURE IN PATIENTS WITH DIFFERENTIATED THYROID CANCER

Kalarrytou M.1, Mantzou E.1, Boutsiadis A.1, Loukari E.1, Pitsouni E.2, Duntas L.1 1Endocrine Unit, Evgenidion Hospital, University of Athens, Greece, 2Biomedicall Laboratory, Evgenidion Hospital, University of Athens, Greece Abstract Objective: To determine whether and to what extent the acute hypothyroidism induced by thyroid hormone withdrawal (THW) impairs lipid metabolism, body weight (BW), BMI and blood Read More

IMMUNOANALYSIS INDICATES THAT THE SODIUM IODIDE SYMPORTER IS NOT OVEREXPRESSED IN INTRACELLULAR COMPARTMENTS IN THYROID AND BREAST CANCERS

Peyrottes I.1, Navarro V.2, Ondo-Mendez A.4, Marcellin D.3, Bellanger L.3, Marsault R.2, Lindenthal S.2, Ettore F.1, Spinel-Gomez C.5, Pourcher T.2 1Department of Pathology, Center Antoine Lacassagne, Nice, France, 2TIRO, CEA DSV-iBEB-SBTN, CAL, University of Nice Sophia Antipolis, Nice, France, 3CEA center of Marcoule (D.M., L.B.), DSV-iBEB-SBTN, Bagnols-sur-Ceze, France, 4TIRO, CEA DSV-iBEB-SBTN, CAL, University of Nice Read More

MCT8 EXPRESSION IN THYROID CARCINOMAS

Motamedi M.1, von Wasielewski R.1, Friesema C.N.E.2, Visser J.T.2, Brabant G.3 1Institut f?r Pathologie, Medizinische Hochschule Hannover, Germany, 2Department of Internal Medicine, EMCR, Rotterdam, Netherlands, 3Dept. of Endocrinology, Christie Hospital, Manchester, UK Abstract Recently direct effects of T3 via the PI3K pathways have been described favoring differentiation and reducing thyroid growth. As thyroid carcinomas loose Read More

HIF-1? MODULATES PROLIFERATION AND DIFFERENTIATION IN THYROID CARCINOMAS VIA PI3K AND MAPK/ERK SIGNALLING

Williams K.1, Cowen R.1, von Wasielewski R.2, Resch J.4, West C.3, Brabant G.4 1School of Pharmaccy, University of Manchester, UK, 2Dept. of Pathology, Medizinische Hochschule Hannover, Germany, 3Dept. Radiation Oncology, Manchester, UK, 4Dept. of Endocrinology, Christie Hospital, Manchester, UK Abstract HIF-1α upregulated in many tumour types appears to be critical for radio- and chemosensitivity in Read More

RADIOIODINE IS AN EFFECTIVE AND SAFE ADJUVANT TREATMENT IN CHILDREN WITH DIFFERENTIATED THYROID CANCER (DTC

Handkiewicz-Junak D.1, Kropinska A.1, Krajewska J.1, Roskosz J.1, Puch Z.1, Olczyk T.1, Jarzab B.1 1Department of Nuclear Medicine and Endocrine Oncology, MSC Memorial Cancer and Institute of Oncology, Gliwice Branch, Gliwice, Poland Abstract Background: We proved recently that in children adjuvant radioiodine is effective in decreasing risk of locoregional recurrence even after radical surgery. The Read More

CLINICAL UTILITY OF A SECOND RECOMBINANT HUMAN TSH STIMULATION IN DIFFERENTIATED THYROID CANCER PATIENT

Torlontano M.1, Crocetti U.1, Durante C.4, Attard M.5, Maniglia A.5, Tumino S.6, Bruno R.7, Bonfitto N.2, Dicembrino F.3, Varraso A.3, Meringolo D.8, Filetti S.4, Trischitta V.1,4,9 1Units of Endocrinology, 2Thoracic Surgery, 3Nuclear Medicine, Scientific Institute Casa Sollievo della Sofferenza, S. Giovanni Rotondo, Italy, 4Department of Clinical Sciences, Sapienza University, Rome, Italy, 5Unit of Endocrinology, Cervello Read More