A LOW MOLECULAR WEIGHT ANTAGONIST PREVENTS TSH- AND ANTIBODY-INDUCED ACTIVATION OF THE HUMAN THYROTROPIN RECEPTOR

Krause G.1, Neumann S.2, Kleinau G.1, Costanzi S.2, Moore S.2, Jiang J.3, Raaka B. M.2, Thomas J. C.3, Gershengorn C. M.2 1Leibniz-Institut f?r Molekulare Pharmakologie, Berlin, Germany, 2National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA, 3NIH Chemical Genomics Center, National Human Genome Research Institute, Bethesda, MD, USA Abstract The thyroid-stimulating Read More

VANDETANIB (300 MG) IN METASTATIC HEREDITARY MEDULLARY THYROID CANCER: A PHASE II OPEN-LABEL STUDY

Wells A.S.1, Gosnell J.2, Gagel F.R.3, Moley J.4, Pfister D.5,Sosa J.A.6, Skinner M.A.7, Krebs A.D.8, Vasselli J.9, Schlumberger M.10 1Washington University School of Medicine, St Louis, MO, USA, 2University of California at San Francisco, San Francisco, CA, USA, 3UTMD Anderson Cancer Center, Houston, TX, USA, 4Washington University School of Medicine, St Louis, MO, USA, 5Memorial Read More

IMMUNOANALYSIS INDICATES THAT THE SODIUM IODIDE SYMPORTER IS NOT OVEREXPRESSED IN INTRACELLULAR COMPARTMENTS IN THYROID AND BREAST CANCERS

Peyrottes I.1, Navarro V.2, Ondo-Mendez A.4, Marcellin D.3, Bellanger L.3, Marsault R.2, Lindenthal S.2, Ettore F.1, Spinel-Gomez C.5, Pourcher T.2 1Department of Pathology, Center Antoine Lacassagne, Nice, France, 2TIRO, CEA DSV-iBEB-SBTN, CAL, University of Nice Sophia Antipolis, Nice, France, 3CEA center of Marcoule (D.M., L.B.), DSV-iBEB-SBTN, Bagnols-sur-Ceze, France, 4TIRO, CEA DSV-iBEB-SBTN, CAL, University of Nice Read More

MCT8 EXPRESSION IN THYROID CARCINOMAS

Motamedi M.1, von Wasielewski R.1, Friesema C.N.E.2, Visser J.T.2, Brabant G.3 1Institut f?r Pathologie, Medizinische Hochschule Hannover, Germany, 2Department of Internal Medicine, EMCR, Rotterdam, Netherlands, 3Dept. of Endocrinology, Christie Hospital, Manchester, UK Abstract Recently direct effects of T3 via the PI3K pathways have been described favoring differentiation and reducing thyroid growth. As thyroid carcinomas loose Read More

HIF-1? MODULATES PROLIFERATION AND DIFFERENTIATION IN THYROID CARCINOMAS VIA PI3K AND MAPK/ERK SIGNALLING

Williams K.1, Cowen R.1, von Wasielewski R.2, Resch J.4, West C.3, Brabant G.4 1School of Pharmaccy, University of Manchester, UK, 2Dept. of Pathology, Medizinische Hochschule Hannover, Germany, 3Dept. Radiation Oncology, Manchester, UK, 4Dept. of Endocrinology, Christie Hospital, Manchester, UK Abstract HIF-1α upregulated in many tumour types appears to be critical for radio- and chemosensitivity in Read More

RADIOIODINE IS AN EFFECTIVE AND SAFE ADJUVANT TREATMENT IN CHILDREN WITH DIFFERENTIATED THYROID CANCER (DTC

Handkiewicz-Junak D.1, Kropinska A.1, Krajewska J.1, Roskosz J.1, Puch Z.1, Olczyk T.1, Jarzab B.1 1Department of Nuclear Medicine and Endocrine Oncology, MSC Memorial Cancer and Institute of Oncology, Gliwice Branch, Gliwice, Poland Abstract Background: We proved recently that in children adjuvant radioiodine is effective in decreasing risk of locoregional recurrence even after radical surgery. The Read More

CLINICAL UTILITY OF A SECOND RECOMBINANT HUMAN TSH STIMULATION IN DIFFERENTIATED THYROID CANCER PATIENT

Torlontano M.1, Crocetti U.1, Durante C.4, Attard M.5, Maniglia A.5, Tumino S.6, Bruno R.7, Bonfitto N.2, Dicembrino F.3, Varraso A.3, Meringolo D.8, Filetti S.4, Trischitta V.1,4,9 1Units of Endocrinology, 2Thoracic Surgery, 3Nuclear Medicine, Scientific Institute Casa Sollievo della Sofferenza, S. Giovanni Rotondo, Italy, 4Department of Clinical Sciences, Sapienza University, Rome, Italy, 5Unit of Endocrinology, Cervello Read More

TELOMERASE-DRIVEN EXPRESSION OF THE SODIUM IODIDE SYMPORTER (NIS) FOR IN VIVO RADIOIODIDE IMAGING AND TREATMENT OF CANCER: A NEW BROAD-SPECTRUM NIS-MEDIATED ANTITUMOUR APPROACH

Riesco-Eizaguirre G.1, De La Vieja A.2, Rodriguez-Garcia I.2, Martin-Duque P.3, Vassaux G.4, Santisteban P.2 1Hospital Universitario La Paz, Madrid, Spain, 2Instituto de Investigaciones Biomedicas “Alberto Sols”, CSIC-UAM, Madrid, Spain, 3Departamento de Biotecnologia, Universidad Francisco de Vitoria, Madrid, Spain, 4Centre for Molecular Oncology, Institute of Cancer, Queen Mary’s School of Medicine and Dentistry, London, UK Abstract Read More

A LINK BETWEEN X CHROMOSOME INACTIVATION PATTERN AND SUBCLINICAL AUTOIMMUNE THYROID DISEASE EVIDENCE FROM A TWIN STUDY

Hansen P.S.1, Brix T.H.2, Knudsen G.P.S.3, Kringen M.K.3, Kyvik K O.1, Sorensen T. H.I.A.4, Orstavik K.H.5, Heged?s L.2 1The Danish Twin Registry, University of Southern Denmark, Odense, Denmark, 2Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark, 3Faculty Division Rikshospitalet, University of Oslo, Oslo, Norway, 4Danish Epidemiology Science Centre, Institute of Preventive Medicine, Copenhagen Read More

EFFECT OF THYROID STATUS ON THE SKELETON IN POST-MENOPAUSAL WOMEN: THE OPUS STUDY

Williams G.R. 1, Murphy E.1, Gl?er C.C.2, Reid M.D.3, Felsenberg D.4, Roux C.5, Eastell R.6 1Molecular Endocrinology Group, Imperial College London, London, UK, 2Universitätsklinikum Schleswig-Holstein, Kiel, Germany, 3Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, UK, 4Free University, Berlin, Germany, 5Rene Descartes University, Paris, France, 6Academic Unit of Bone Metabolism, University of Sheffield, Sheffield, Read More